Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joshua R Cook"'
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 11, Pp 100278- (2022)
The small intestinal epithelium has classically been envisioned as a conduit for nutrient absorption, but appreciation is growing for a larger and more dynamic role for enterocytes in lipid metabolism. Considerable gaps remain in our knowledge of thi
Externí odkaz:
https://doaj.org/article/5c10cc5d6cf5482a86ceb180042612c6
Autor:
María Concepción Izquierdo, Niroshan Shanmugarajah, Samuel X. Lee, Michael J. Kraakman, Marit Westerterp, Takumi Kitamoto, Michael Harris, Joshua R. Cook, Galina A. Gusarova, Kendra Zhong, Elijah Marbuary, InSug O-Sullivan, Nikolaus Rasmus, Stefania Camastra, Terry G. Unterman, Ele Ferrannini, Barry E. Hurwitz, Rebecca A. Haeusler
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)
Multiple beneficial cardiovascular effects of HDL depend on sphingosine-1-phosphate (S1P). S1P associates with HDL by binding to apolipoprotein M (ApoM). Insulin resistance is a major driver of dyslipidemia and cardiovascular risk. However, the mecha
Externí odkaz:
https://doaj.org/article/1bec1268dd814e7492b3638624ca8bed
Autor:
John Ausiello, Joshua R Cook
Publikováno v:
Reviews in Endocrine & Metabolic Disorders
SARS-CoV-2, the virus responsible for COVID-19, uses angiotensin converting enzyme 2 (ACE2) as its primary cell-surface receptor. ACE2 is a key enzyme in the counter-regulatory pathway of the broader renin-angiotensin system (RAS) that has been impli
Autor:
Rafael Mayoral, Olivia Osborn, Joanne McNelis, Andrew M. Johnson, Da Young Oh, Cristina Llorente Izquierdo, Heekyung Chung, Pingping Li, Paqui G. Traves, Gautam Bandyopadhyay, Ariane R. Pessentheiner, Jachelle M. Ofrecio, Joshua R. Cook, Li Qiang, Domenico Accili, Jerrold M. Olefsky
Publikováno v:
Molecular Metabolism, Vol 4, Iss 5, Pp 378-391 (2015)
Objective: Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcri
Externí odkaz:
https://doaj.org/article/aa5602b006754977b466515665297212
Autor:
Kartik Sehgal, Claire McGroder, David S. Seres, Behnood Bikdeli, Daniel Shalev, Anna S. Nordvig, Donald Dietz, Akinpelumi A Beckley, Donald W. Landry, Allan Schwartz, Christine Kim Garcia, John P. Bilezikian, Tejasav S. Sehrawat, Jacob S. Stevens, Domenico Accili, Nadia Liyanage-Don, Aakriti Gupta, Elana J. Bernstein, John C. Ausiello, Gregg F. Rosner, Nir Uriel, Elaine Wan, Ani Nalbandian, Neha Ahluwalia, Sumit Mohan, Toni K. Choueiri, Mahesh V. Madhavan, Joshua R. Cook, Daniel E. Freedberg, Daniel Brodie, Matthew R. Baldwin, Caroline Der-Nigoghossian, Mitchell S.V. Elkind, Jean M. Connors
Publikováno v:
Nat Med
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06ab025d3721105a3b45a10b352296a
https://europepmc.org/articles/PMC8893149/
https://europepmc.org/articles/PMC8893149/
Autor:
Susan Restaino, Charles Marboe, Joshua R. Cook, Edward Lin, Jamie Diamond, Nicholas O. Palmeri, Rachel Bijou
Publikováno v:
Circulation: Heart Failure. 13
Publikováno v:
Diabetes
Hypothalamic neurons expressing agouti-related peptide (AgRP) regulate eating and glucose metabolism. Ablation of FOXO1 in AgRP neurons of mice results in reduced food intake, leanness, improved glucose homeostasis, and increased sensitivity to insul
Autor:
Paqui G. Través, Gautam Bandyopadhyay, Domenico Accili, Li Qiang, Ariane Pessentheiner, Joshua R. Cook, Olivia Osborn, Jerrold M. Olefsky, Jachelle M. Ofrecio, Joanne C. McNelis, Cristina Llorente Izquierdo, Pingping Li, Andrew M.F. Johnson, Heekyung Chung, Da Young Oh, Rafael Mayoral
Publikováno v:
Molecular Metabolism, Vol 4, Iss 5, Pp 378-391 (2015)
Molecular Metabolism
Molecular Metabolism
Objective Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcrip
Autor:
Joshua R. Cook, Robert K. Semple
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:1544-1554
Adiponectin is a highly abundant plasma protein synthesized nearly exclusively in adipose tissue from the ADIPOQ gene. It has excited intense interest because of robust correlation of its circulating levels with indices of insulin resistance (IR) and