Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joshua Paterson"'
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Clear cell renal cell carcinoma (ccRCC) is a markedly heterogeneous disease in many aspects, including the tumour microenvironment. Our previous study showed the importance of the tumour microenvironment in ccRCC xeno-transplant s
Externí odkaz:
https://doaj.org/article/c7841f902b31449fa1f2fe13942a0cc0
Autor:
Mauricio Medrano, Laudine Communal, Kevin R. Brown, Marcin Iwanicki, Josee Normand, Joshua Paterson, Fabrice Sircoulomb, Paul Krzyzanowski, Marian Novak, Sasha A. Doodnauth, Fernando Suarez Saiz, Jane Cullis, Rima Al-awar, Benjamin G. Neel, John McPherson, Ronny Drapkin, Laurie Ailles, Anne-Marie Mes-Massons, Robert Rottapel
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2343-2358 (2017)
The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and comprehensive expression
Externí odkaz:
https://doaj.org/article/5c7651cc95f944028100473e51fbc84b
Autor:
Craig A Gedye, Ali Hussain, Joshua Paterson, Alannah Smrke, Harleen Saini, Danylo Sirskyj, Keira Pereira, Nazleen Lobo, Jocelyn Stewart, Christopher Go, Jenny Ho, Mauricio Medrano, Elzbieta Hyatt, Julie Yuan, Stevan Lauriault, Mona Meyer, Maria Kondratyev, Twan van den Beucken, Michael Jewett, Peter Dirks, Cynthia J Guidos, Jayne Danska, Jean Wang, Bradly Wouters, Benjamin Neel, Robert Rottapel, Laurie E Ailles
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105602 (2014)
Cell surface proteins have a wide range of biological functions, and are often used as lineage-specific markers. Antibodies that recognize cell surface antigens are widely used as research tools, diagnostic markers, and even therapeutic agents. The a
Externí odkaz:
https://doaj.org/article/26b8358f2d6c4080bcea0ab7bd509e76
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
The mechanisms underlying zebrafish pancreatic islet vascularization have not been well characterized. We sought to determine the angiogenic factors responsible for islet vascularization and assess whether an absence of endothelial cells affects beta
Autor:
Laurie Ailles, Christina Karamboulas, Victor W.H. Ho, Jalna Meens, Ali Hussain, Stephanie Poon, Gary D. Bader, Benjamin G. Neel, Veronique Voisin, Blaise A. Clarke, Julia Dmytryshyn, Joshua Paterson, Marcus Q. Bernardini, Kwan Ho Tang, Ngoc Hoang Bao Bui
Publikováno v:
The Journal of Experimental Medicine
In this study, Hussain et al. demonstrate that cancer-associated fibroblasts (CAFs) in high-grade serous ovarian cancer are heterogeneous, that CAF state drives cancer aggressiveness and patient outcomes, and that TCF21 is a master regulator of CAF s
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Cancer
BMC Cancer
Background Clear cell renal cell carcinoma (ccRCC) is a markedly heterogeneous disease in many aspects, including the tumour microenvironment. Our previous study showed the importance of the tumour microenvironment in ccRCC xeno-transplant success ra
Autor:
Kurosh Rahimi, Anne-Marie Mes-Masson, Fabrice Sircoulomb, Laurie Ailles, Amit M. Oza, Diane Provencher, Joshua Paterson, Martin Köbel, Laudine Communal, Mauricio Medrano, Dongsheng Tu, Paul Hoskins, Stephanie Lheureux, Robert Rottapel
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 33(11)
High-grade serous carcinoma of uterine adnexa (HGSC) is the most frequent histotype of epithelial ovarian cancer and has a poor 5-year survival rate due to late-stage diagnosis and the poor efficacy of standard treatments. Novel biomarkers of cancer
Autor:
Benjamin G. Neel, Laudine Communal, Kevin R. Brown, Fernando Suarez Saiz, Sasha A. Doodnauth, Mauricio Medrano, Marian Novak, Rima Al-awar, Marcin P. Iwanicki, Jane Cullis, John Douglas Mcpherson, Robert Rottapel, Fabrice Sircoulomb, Josee Normand, Joshua Paterson, Anne Marie Mes-Massons, Laurie Ailles, Paul M. Krzyzanowski, Ronny Drapkin
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2343-2358 (2017)
The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and comprehensive expression
Autor:
Ali Hussain, Blaise A. Clarke, Marcus Q. Bernardini, Julia Dmytryshyn, Jalna Meens, Joshua Paterson, Laurie Ailles, Kwan Ho Tang, Benjamin G. Neel, Victor W.H. Ho, Stephanie Poon, Veronique Voisin, Gary D. Bader
Recent studies indicate that cancer-associated fibroblasts (CAFs) are phenotypically and functionally heterogeneous. However, little is known about CAF subtypes, the roles they play in cancer progression, and molecular mediators of the CAF “state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929c4506086b51651da109421b21ee88
Autor:
Joshua Paterson, Laurie Ailles
Publikováno v:
Flow Cytometry Protocols ISBN: 9781493973446
Cell surface proteins are widely studied in the search for new biomarkers and therapeutic targets, but there is little information available about the surfaceome of individual cells, and this is difficult to obtain experimentally, especially in heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffc75b0d5f2576a04bdf721399e8f95c
https://doi.org/10.1007/978-1-4939-7346-0_7
https://doi.org/10.1007/978-1-4939-7346-0_7