Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joshua P. Whitt"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
BK potassium channels have been previously shown to mediate SCN circadian firing, although the precise mechanisms are unclear. Here, using knockout and rescue approaches, the authors find that the ß2 ‘ball-and-chain’ confers BK channel inactivat
Externí odkaz:
https://doaj.org/article/71b72ebbc6e9459fb23474859a7f793f
Autor:
Janice A. Dominov, Laura A. Madigan, Joshua P. Whitt, Katerina L. Rademacher, Kristin M. Webster, Hesheng Zhang, Haruhiko Banno, Siqi Tang, Yifan Zhang, Nicholas Wightman, Emma M. Shychuck, John Page, Alexandra Weiss, Karen Kelly, Alper Kucukural, Michael H. Brodsky, Alexander Jaworski, Justin R. Fallon, Diane Lipscombe, Robert H. Brown
Publikováno v:
bioRxiv
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder affecting brain and spinal cord motor neurons. Mutations in the copper/zinc superoxide dismutase gene (SOD1) are associated with ∼20% of inherited and 1-2% of sporadic ALS c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0de160fc2e91574d01f7d30c4af0729
https://doi.org/10.1101/2023.05.05.539444
https://doi.org/10.1101/2023.05.05.539444
Publikováno v:
Frontiers in Sports and Active Living, Vol 6 (2024)
The rise of youth sport academies has led to a focus on long-term athletic development, and exploration into holistic approaches that incorporate psychological attributes to form biopsychosocial frameworks. The primary aim of this systematic review w
Externí odkaz:
https://doaj.org/article/18dd86c922c5448cbb8c16c9db35470d
Publikováno v:
J Neurophysiol
Mammalian circadian (24 h) rhythms are timed by the pattern of spontaneous action potential firing in the suprachiasmatic nucleus (SCN). This oscillation in firing is produced through circadian regulation of several membrane currents, including large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f6aab90a820d242b863277d483aff2
https://europepmc.org/articles/PMC8409951/
https://europepmc.org/articles/PMC8409951/
Publikováno v:
The Journal of General Physiology
Large conductance K+ (BK) channels require intracellular Ca2+ provided by Ca2+ channels to open at physiological membrane potentials. Whitt et al. identify the Ca2+ channel subtypes that activate BK current in the suprachiasmatic nucleus to enable ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6d0be10533f12d468614d50cb585fc
https://doi.org/10.1085/jgp.201711945
https://doi.org/10.1085/jgp.201711945
Autor:
Joshua P. Whitt, Natalie Chapkis, Joshua Amaya, Aaron Held, Anne C. Hart, Nicolas L. Fawzi, Amanda Duffy, Diane Lipscombe, Veronica H Ryan, Beatrice L. Steinert, Katherine S. Yanagi, Arjun D. Mathur, Zhijin Wu, Kristi A. Wharton, Kathryn Russo, Robert A. Reenan, Kaitlyn H. Hajdarovic, Justin R. Fallon
Publikováno v:
Neuroscience. 396
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that has significant overlap with frontotemporal dementia (FTD). Mutations in specific genes have been identified that can cause and/or predispose patients to ALS. However, the clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9101633a4a8be9c6b17429074ff7e111
https://pubmed.ncbi.nlm.nih.gov/30476526
https://pubmed.ncbi.nlm.nih.gov/30476526
Publikováno v:
Biophysical Journal. 114:131a-132a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb36801d69839166e744229c94fe2887
https://doi.org/10.1016/j.bpj.2017.11.746
https://doi.org/10.1016/j.bpj.2017.11.746
Publikováno v:
American Journal of Physiology-Cell Physiology. 304:C299-C311
In mammals, almost all aspects of circadian rhythmicity are attributed to activity in a discrete neural circuit of the hypothalamus, the suprachiasmatic nucleus (SCN). A 24-h rhythm in spontaneous firing is the fundamental neural intermediary to circ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11751bf090e522f5722c2c81caab792
https://doi.org/10.1152/ajpcell.00302.2012
https://doi.org/10.1152/ajpcell.00302.2012
Publikováno v:
The Journal of General Physiology
BK Ca2+-activated K+ currents exhibit diverse properties across tissues. The functional variation in voltage- and Ca2+-dependent gating underlying this diversity arises from multiple mechanisms, including alternate splicing of Kcnma1, the gene encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed10787388d215a5b467f0bb402bb6c
http://europepmc.org/articles/PMC3840924
http://europepmc.org/articles/PMC3840924
Autor:
Joshua P. Whitt, Michael A. McDannald, Patrick T. Piantadosi, Rose-Marie Karlsson, Patricio O'Donnell, Geoffrey Schoenbaum, Gwendolyn G. Calhoon
Publikováno v:
Biological Psychiatry. 70:1122-1126
Background Schizophrenia is a chronic and devastating brain disorder characterized by hallucinations and delusions, symptoms reflecting impaired reality testing. Although animal models have captured negative symptoms and cognitive deficits associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7432a0401bfdb1433915fc056949a81
https://doi.org/10.1016/j.biopsych.2011.06.014
https://doi.org/10.1016/j.biopsych.2011.06.014