Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Joshua P. Nixon"'
Autor:
Janeen H. Trembley, Paul Barach, Julie M. Tomáška, Jedidah T. Poole, Pamela K. Ginex, Robert F. Miller, Jacob B. Lindheimer, Anthony M. Szema, Kimberly Gandy, Trishul Siddharthan, Jason P. Kirkness, Joshua P. Nixon, Rosie Lopez Torres, Mark A. Klein, Timothy R. Nurkiewicz, Tammy A. Butterick
Publikováno v:
Particle and Fibre Toxicology, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Millions of United States (U.S.) troops deployed to the Middle East and Southwest Asia were exposed to toxic airborne hazards and/or open-air burn pits. Burn pit emissions contain particulate matter combined with toxic gasses and heavy metal
Externí odkaz:
https://doaj.org/article/f6a54d160d4d450db019d44fb0c34f7c
Autor:
Janeen H. Trembley, Simon W. So, Joshua P. Nixon, Elizabeth C. Bowdridge, Krista L. Garner, Julie Griffith, Kevin J. Engles, Thomas P. Batchelor, William T. Goldsmith, Julie M. Tomáška, Salik Hussain, Timothy R. Nurkiewicz, Tammy A. Butterick
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-7 (2022)
Abstract Objective Chronic multisymptom illness (CMI) is an idiopathic disease affecting thousands of U.S. Veterans exposed to open-air burn pits emitting aerosolized particulate matter (PM) while serving in Central and Southwest Asia and Africa. Exp
Externí odkaz:
https://doaj.org/article/3ca18ac35158413d88e370b7593c9165
Publikováno v:
Nanomaterials, Vol 8, Iss 3, p 155 (2018)
The brain is the central regulator for integration and control of responses to environmental cues. Previous studies suggest that air pollution may directly impact brain health by triggering the onset of chronic neuroinflammation. We hypothesize that
Externí odkaz:
https://doaj.org/article/8c74c7a8ac16424488062a25a2e525c3
Autor:
Rishav, Aggarwal, Steven S, Qi, Simon W, So, Cory, Swingen, Christina P, Reyes, Rebecca, Rose, Christin, Wright, Laura L, Hocum Stone, Joshua P, Nixon, Edward O, McFalls, Tammy A, Butterick, Rosemary F, Kelly
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 165:e269-e279
A porcine model was used to study diastolic dysfunction in hibernating myocardium (HM) and recovery with coronary artery bypass surgery (CABG).HM was induced in Yorkshire-Landrace juvenile swine (n = 30) by placing a c-constrictor on left anterior de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e13f789ffecd64d47ae14de7e1363e1
https://doi.org/10.1016/j.jtcvs.2022.08.010
https://doi.org/10.1016/j.jtcvs.2022.08.010
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3381
Volume 24
Issue 4
Pages: 3381
Microglial fatty-acid binding protein 4 (FABP4) is a regulator of neuroinflammation. We hypothesized that the link between lipid metabolism and inflammation indicates a role for FABP4 in regulating high fat diet (HFD)-induced cognitive decline. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03210696afa80b13fb19d1b99a8cc79
Publikováno v:
Nutrients; Volume 15; Issue 11; Pages: 2494
Obesity, a known risk factor of Alzheimer’s disease (AD), increases the activation of microglia, leading to a proinflammatory phenotype. Our previous work shows that a high fat diet (HFD) can cause neuroinflammation and cognitive decline in mice. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9359e25d2132ada97eb92af982c6b90c
https://doi.org/10.3390/nu15112494
https://doi.org/10.3390/nu15112494
Autor:
Simon W. So, Kendra M. Fleming, Cayla M. Duffy, Joshua P. Nixon, David A. Bernlohr, Tammy A. Butterick
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4354
The microglial fatty-acid-binding protein 4-uncoupling protein 2 (FABP4-UCP2) axis is a key regulator of neuroinflammation in high-fat-diet (HFD)-fed animals, indicating a role for FABP4 in brain immune response. We hypothesized that the FABP4-UCP2 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41169792dfc8498ea9d3c5a2129140d
https://pubmed.ncbi.nlm.nih.gov/35457171
https://pubmed.ncbi.nlm.nih.gov/35457171
Autor:
Tammy A. Butterick, Charles J. Billington, Joshua P. Nixon, Vijayakumar Mavanji, Catherine M. Kotz, Cayla M. Duffy
Publikováno v:
Neurobiology of Learning and Memory. 146:21-30
Orexin A is produced in neurons of the lateral, perifornical and dorsomedial regions of the lateral hypothalamic area, which then project widely throughout the central nervous system to regulate arousal state, sleep-wake architecture, energy homeosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2dd9e8d59f0c4b566b3a0cce8771a61
https://doi.org/10.1016/j.nlm.2017.10.014
https://doi.org/10.1016/j.nlm.2017.10.014
Publikováno v:
Molecular and Cellular Neuroscience. 75:93-100
Palmitic acid (PA), an abundant dietary saturated fatty acid, contributes to obesity and hypothalamic dysregulation in part through increase in oxidative stress, insulin resistance, and neuroinflammation. Increased production of reactive oxygen speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c264e0a42eab5e547768ee0b06d2449d
https://doi.org/10.1016/j.mcn.2016.07.003
https://doi.org/10.1016/j.mcn.2016.07.003
Publikováno v:
Neurobiology of learning and memory. 157
Midlife obesity is a risk factor for cognitive decline and is associated with the earlier onset of Alzheimer's disease (AD). Diets high in saturated fat potentiate the onset of obesity, microglial activation, and neuroinflammation. Signaling deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba2ab04aec47a63c37fe433a0a7ec9a
https://pubmed.ncbi.nlm.nih.gov/30471346
https://pubmed.ncbi.nlm.nih.gov/30471346