Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Joshua P. Nixon"'
Autor:
Janeen H. Trembley, Simon W. So, Joshua P. Nixon, Elizabeth C. Bowdridge, Krista L. Garner, Julie Griffith, Kevin J. Engles, Thomas P. Batchelor, William T. Goldsmith, Julie M. Tomáška, Salik Hussain, Timothy R. Nurkiewicz, Tammy A. Butterick
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-7 (2022)
Abstract Objective Chronic multisymptom illness (CMI) is an idiopathic disease affecting thousands of U.S. Veterans exposed to open-air burn pits emitting aerosolized particulate matter (PM) while serving in Central and Southwest Asia and Africa. Exp
Externí odkaz:
https://doaj.org/article/3ca18ac35158413d88e370b7593c9165
Publikováno v:
Nutrients, Vol 15, Iss 11, p 2494 (2023)
Obesity, a known risk factor of Alzheimer’s disease (AD), increases the activation of microglia, leading to a proinflammatory phenotype. Our previous work shows that a high fat diet (HFD) can cause neuroinflammation and cognitive decline in mice. W
Externí odkaz:
https://doaj.org/article/5a822f27b9934947bc72c006f0f17773
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3381 (2023)
Microglial fatty-acid binding protein 4 (FABP4) is a regulator of neuroinflammation. We hypothesized that the link between lipid metabolism and inflammation indicates a role for FABP4 in regulating high fat diet (HFD)-induced cognitive decline. We ha
Externí odkaz:
https://doaj.org/article/1af8c685d07e4b95a3665c6c48c9129f
Autor:
Simon W. So, Kendra M. Fleming, Cayla M. Duffy, Joshua P. Nixon, David A. Bernlohr, Tammy A. Butterick
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4354 (2022)
The microglial fatty-acid-binding protein 4-uncoupling protein 2 (FABP4-UCP2) axis is a key regulator of neuroinflammation in high-fat-diet (HFD)-fed animals, indicating a role for FABP4 in brain immune response. We hypothesized that the FABP4-UCP2 a
Externí odkaz:
https://doaj.org/article/bc7406ef60eb4457ba6fb4972b96c28c
Publikováno v:
Nanomaterials, Vol 8, Iss 3, p 155 (2018)
The brain is the central regulator for integration and control of responses to environmental cues. Previous studies suggest that air pollution may directly impact brain health by triggering the onset of chronic neuroinflammation. We hypothesize that
Externí odkaz:
https://doaj.org/article/8c74c7a8ac16424488062a25a2e525c3
Autor:
Rishav, Aggarwal, Steven S, Qi, Simon W, So, Cory, Swingen, Christina P, Reyes, Rebecca, Rose, Christin, Wright, Laura L, Hocum Stone, Joshua P, Nixon, Edward O, McFalls, Tammy A, Butterick, Rosemary F, Kelly
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 165:e269-e279
A porcine model was used to study diastolic dysfunction in hibernating myocardium (HM) and recovery with coronary artery bypass surgery (CABG).HM was induced in Yorkshire-Landrace juvenile swine (n = 30) by placing a c-constrictor on left anterior de
Autor:
Tammy A. Butterick, Charles J. Billington, Joshua P. Nixon, Vijayakumar Mavanji, Catherine M. Kotz, Cayla M. Duffy
Publikováno v:
Neurobiology of Learning and Memory. 146:21-30
Orexin A is produced in neurons of the lateral, perifornical and dorsomedial regions of the lateral hypothalamic area, which then project widely throughout the central nervous system to regulate arousal state, sleep-wake architecture, energy homeosta
Publikováno v:
Molecular and Cellular Neuroscience. 75:93-100
Palmitic acid (PA), an abundant dietary saturated fatty acid, contributes to obesity and hypothalamic dysregulation in part through increase in oxidative stress, insulin resistance, and neuroinflammation. Increased production of reactive oxygen speci
Autor:
Charles J. Billington, Catherine M. Kotz, Tammy A. Butterick, Lauren E. Wisdorf, Cayla M. Duffy, Joshua P. Nixon, Ce Yuan
Publikováno v:
Neuroscience Letters. 606:140-144
Excess dietary saturated fatty acids such as palmitic acid (PA) induce peripheral and hypothalamic inflammation. Hypothalamic inflammation, mediated in part by microglial activation, contributes to metabolic dysregulation. In rodents, high fat diet-i
Publikováno v:
Neurobiology of learning and memory. 157
Midlife obesity is a risk factor for cognitive decline and is associated with the earlier onset of Alzheimer's disease (AD). Diets high in saturated fat potentiate the onset of obesity, microglial activation, and neuroinflammation. Signaling deficien