Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joshua P Katz"'
Autor:
Joshua L. Katz, Yuheng Geng, Leah K. Billingham, Nishanth S. Sadagopan, Susan L. DeLay, Jay Subbiah, Tzu-yi Chia, Graysen McManus, Chao Wei, Hanxiang Wang, Hanchen Lin, Caylee Silvers, Lauren K. Boland, Si Wang, Hanxiao Wan, David Hou, Gustavo Ignacio Vázquez-Cervantes, Tarlan Arjmandi, Zainab H. Shaikh, Peng Zhang, Atique U. Ahmed, Deanna M. Tiek, Catalina Lee-Chang, Edward T. Chouchani, Jason Miska
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Glioblastoma is a Grade 4 primary brain tumor defined by therapy resistance, diffuse infiltration, and near-uniform lethality. The underlying mechanisms are unknown, and no treatment has been curative. Using a recently developed creatine kin
Externí odkaz:
https://doaj.org/article/dd7a023fe4514c80a5ab446bc7743f92
Autor:
Christopher B Buck, Koenraad Van Doorslaer, Alberto Peretti, Eileen M Geoghegan, Michael J Tisza, Ping An, Joshua P Katz, James M Pipas, Alison A McBride, Alvin C Camus, Alexa J McDermott, Jennifer A Dill, Eric Delwart, Terry F F Ng, Kata Farkas, Charlotte Austin, Simona Kraberger, William Davison, Diana V Pastrana, Arvind Varsani
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005574 (2016)
Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches
Externí odkaz:
https://doaj.org/article/7739ad4591ff4b3b9ba8b0164dfb5663
Autor:
Tzu-Yi Chia, Leah K. Billingham, Lauren Boland, Joshua L. Katz, Victor A. Arrieta, Jack Shireman, Aurora-Lopez Rosas, Susan L. DeLay, Kaylee Zillinger, Yuheng Geng, Jeandre Kruger, Caylee Silvers, Hanxiang Wang, Gustavo Ignacio Vazquez Cervantes, David Hou, Si Wang, Hanxiao Wan, Adam Sonabend, Peng Zhang, Catalina Lee-Chang, Jason Miska
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionGlioblastoma multiforme (GBM) pathobiology is characterized by its significant induction of immunosuppression within the tumor microenvironment, predominantly mediated by immunosuppressive tumor-associated myeloid cells (TAMCs). Myeloid c
Externí odkaz:
https://doaj.org/article/6a594d57504c4cf7a725f6df7d76a523
Autor:
David Hou, Hanxiao Wan, Joshua L. Katz, Si Wang, Brandyn A. Castro, Gustavo I. Vazquez-Cervantes, Victor A. Arrieta, Silpol Dhiantravan, Hinda Najem, Aida Rashidi, Tzu-yi Chia, Tarlan Arjmandi, Jimena Collado, Leah Billingham, Aurora Lopez-Rosas, Yu Han, Adam M. Sonabend, Amy B. Heimberger, Peng Zhang, Jason Miska, Catalina Lee-Chang
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Understanding the spatial relationship and functional interaction of immune cells in glioblastoma (GBM) is critical for developing new therapeutics that overcome the highly immunosuppressive tumor microenvironment. Our study showed that B and T cells
Externí odkaz:
https://doaj.org/article/6ecf574030ed40ef851a4a0c31efda84
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102219- (2023)
Summary: A B-cell-based cellular vaccine (BVax), produced from 4-1BBL+ B cells, can select tumor-specific B cells that, upon ex vivo culture, can generate tumor-specific antibodies and activate T cells. Here, we present a protocol to generate a B-cel
Externí odkaz:
https://doaj.org/article/5abbda33185948a6bba4f117b8eb55ed
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
NPJ Genomic Medicine
NPJ Genomic Medicine
Oncogenic human papillomavirus (HPV) genomes are often integrated into host chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single copy, or as tandem repeats of viral DNA interspersed with, or without, host DNA. Integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8d004a394de64e1cb06290623b3e80
https://doaj.org/article/2f2cfc279c734d6eb70f9f70b5b5de01
https://doaj.org/article/2f2cfc279c734d6eb70f9f70b5b5de01
Publikováno v:
Virology. 513:208-216
We have developed a virus detection and discovery computational pipeline, Pickaxe, and applied it to NGS databases provided by The Cancer Genome Atlas (TCGA). We analyzed a collection of whole genome (WGS), exome (WXS), and RNA (RNA-Seq) sequencing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0dd012d970681cfac544b3b2c31575
https://doi.org/10.1016/j.virol.2017.10.017
https://doi.org/10.1016/j.virol.2017.10.017
Publikováno v:
Journal of Virology. 89:4051-4057
We searched The Cancer Genome Atlas (TCGA) database for viruses by comparing non-human reads present in transcriptome sequencing (RNA-Seq) and whole-exome sequencing (WXS) data to viral sequence databases. Human papillomavirus 18 (HPV18) is an etiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe33fb780f56217142b4b6f9317231cb
https://doi.org/10.1128/jvi.03365-14
https://doi.org/10.1128/jvi.03365-14
Autor:
James M. Pipas, Reuben S. Harris, Joshua P. Katz, Keiko Akagi, James A. DeCaprio, Jingwei Cheng, Christina Marcelus, Linda C. Wang, Guilherme Rabinowits, Manisha Thakuria, Gabriel J. Starrett, Paul G. Cantalupo, David E. Symer
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
mBio, Vol 8, Iss 1, p e02079-16 (2017)
mBio
mBio, Vol 8, Iss 1, p e02079-16 (2017)
mBio
Merkel cell polyomavirus is the primary etiological agent of the aggressive skin cancer Merkel cell carcinoma (MCC). Recent studies have revealed that UV radiation is the primary mechanism for somatic mutagenesis in nonviral forms of MCC. Here, we an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db9fd69b9afcfe973afcfcb2d4875f5
https://journals.asm.org/doi/10.1128/mBio.02079-16
https://journals.asm.org/doi/10.1128/mBio.02079-16
Autor:
James M. Pipas, Joshua P. Katz
Publikováno v:
BMC Bioinformatics
Background Viral integration into a host genome is defined by two chimeric junctions that join viral and host DNA. Recently, computational tools have been developed that utilize NGS data to detect chimeric junctions. These methods identify individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ab2704b642de79641a4a734fc106f1
http://europepmc.org/articles/PMC4210586
http://europepmc.org/articles/PMC4210586