Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joshua O. Scheys"'
Autor:
Manuel Blandino-Rosano, Joshua O. Scheys, Joao Pedro Werneck-de-Castro, Ruy A. Louzada, Joana Almaça, Gil Leibowitz, Markus A. Rüegg, Michael N. Hall, Ernesto Bernal-Mizrachi
Mammalian target of rapamycin (mTOR) kinase is an essential hub where nutrients and growth factors converge to control cellular metabolism. mTOR interacts with different accessory proteins to form complexes 1 and 2 (mTORC), and each complex has diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37195ff720b5b01918fa4782257d0d4
Autor:
Nahum Sonenberg, Akiko Yanagiya, Aaron Bender, Margarita Jimenez-Palomares, Manuel Blandino-Rosano, Ming Liu, Rebecca Barbaresso, Ernesto Bernal-Mizrachi, Joshua O. Scheys, Liangyou Rui
Publikováno v:
Diabetes
The mammalian target of rapamycin complex 1 (mTORC1) regulates several biological processes, although the key downstream mechanisms responsible for these effects are poorly defined. Using mice with deletion of eukaryotic translation initiation factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d115ab0f22721461edd3b4f0bb7ceabc
https://doi.org/10.2337/db15-1443
https://doi.org/10.2337/db15-1443
Autor:
Bernard P. Schimmer, Joshua O. Scheys, Jennivine Tsao, Sara Mostafavi, Martha Cordova, Quaid Morris
Publikováno v:
Molecular and Cellular Endocrinology. 336:85-91
The contribution of steroidogenic factor 1 (SF-1) to the gene expression profile of Y1 mouse adrenocortical cells was evaluated using short hairpin RNAs to knockdown SF-1. The reduced level of SF-1 RNA was associated with global changes that affected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed9f7bf2ad9532f49b808c24f03d9b6
https://doi.org/10.1016/j.mce.2010.11.024
https://doi.org/10.1016/j.mce.2010.11.024
Autor:
Joshua O. Scheys, Pablo Menendez, K. Sue O'Shea, Santiago Morell, Deanna A. Kulpa, Kathleen L. Collins, Jose L. Garcia-Perez, Maria Morell, Christoph C. Carter, John V. Moran, Gary D. Hammer
Publikováno v:
Nature
Long INterspersed Element-1 (LINE-1 or L1) retrotransposition continues to impact human genome evolution1,2. L1s can retrotranspose in the germline, during early development, and in select somatic cells3,4,5,6,7,8; however, the host response to L1 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd91fe3cd0b9837254a4d739ce20069
https://doi.org/10.1038/nature09209
https://doi.org/10.1038/nature09209
Publikováno v:
Endocrinology. 149:3668-3678
The type 4 adenylyl cyclase, Adcy4, is the least abundant of five different adenylyl cyclase isoforms expressed in the Y1 mouse adrenocortical cell line and is deficient in a Y1 mutant with impaired steroidogenic factor 1 (SF1) activity. This study e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59c66ea50166b9e10eca21bbc1717f0
https://doi.org/10.1210/en.2008-0203
https://doi.org/10.1210/en.2008-0203
Publikováno v:
Molecular Endocrinology. 20:2711-2723
Numerous genes required for adrenocortical steroidogenesis are activated by the nuclear hormone receptor steroidogenic factor 1 (SF-1) (NR5A1). Dax-1 (NR0B1), another nuclear hormone receptor, represses SF-1-dependent activation. Glucocorticoid produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d10ebad93ace2d37d32da0b8621c2f0
https://doi.org/10.1210/me.2005-0461
https://doi.org/10.1210/me.2005-0461
Autor:
Carol Sweeney, Fred F. Kadlubar, Susan Nowell, Christine B. Ambrosone, Joshua O. Scheys, Stewart L. MacLeod, Jiyoung Ahn, Andrew Trovato, James M. Rae
Publikováno v:
Breast Cancer Research and Treatment. 91:249-258
Tamoxifen has been a mainstay of adjuvant therapy for breast cancer for many years. We sought to determine if genetic variability in the tamoxifen metabolic pathway influenced overall survival in breast cancer patients treated with tamoxifen. We exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5567fb877c2a46383e31bafa140874c2
https://doi.org/10.1007/s10549-004-7751-x
https://doi.org/10.1007/s10549-004-7751-x
Autor:
James M. Rae, Michael C. Kiefer, Marc E. Lippman, Kim M. Clark, Robert B. Chadwick, Joshua O. Scheys
Publikováno v:
Breast Cancer Research and Treatment. 87:87-95
EGFRvIII is a constitutively activated truncated variant of the epidermal growth factor receptor (EGFR) which has been shown to increase tumorgenicity. There are conflicting reports on the extent of EGFRvIII expression in tissues which may in part st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb276270f976415fbfe303e97ceb0af3
https://doi.org/10.1023/b:brea.0000041585.26734.f9
https://doi.org/10.1023/b:brea.0000041585.26734.f9
Publikováno v:
Molecular Pharmacology. 61:436-445
Several previous human postmortem experiments have detected an increase in striatal [(3)H]WIN 35428 binding to the dopamine transporter (DAT) in chronic cocaine users. However, animal experiments have found considerable variability in DAT radioligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b69004ed6ec63d9802113ee6df36b41
https://doi.org/10.1124/mol.61.2.436
https://doi.org/10.1124/mol.61.2.436
Autor:
Manuel Blandino-Rosano, Latif Rachdi, Aruna Sathyamurthy, Daniel Barker, Lynda Elghazi, Emilyn U. Alejandro, Aaron J. Weiss, Brigid Gregg, Ernesto Bernal-Mizrachi, Joshua O. Scheys, A. Y. Chen, Aaron P. Gould
The ability of pancreatic beta cells to proliferate is critical both for normal tissue maintenance and in conditions where there is an increased demand for insulin. Protein kinase B (Akt) plays a major role in promoting proliferation in many cell typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47bc5a61903d6cad4b1fa4ea9b64b94
https://europepmc.org/articles/PMC3646796/
https://europepmc.org/articles/PMC3646796/