Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Joshua N. Leonard"'
Autor:
Justin A. Peruzzi, Taylor F. Gunnels, Hailey I. Edelstein, Peilong Lu, David Baker, Joshua N. Leonard, Neha P. Kamat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Naturally generated lipid nanoparticles termed extracellular vesicles (EVs) hold significant promise as engineerable therapeutic delivery vehicles. However, active loading of protein cargo into EVs in a manner that is useful for delivery rem
Externí odkaz:
https://doaj.org/article/6a7d85c3479547c382c5db225550e86d
Autor:
Roxana E. Mitrut, Devin M. Stranford, Beth N. DiBiase, Jonathan M. Chan, Matthew D. Bailey, Minrui Luo, Clare S. Harper, Thomas J. Meade, Muzhou Wang, Joshua N. Leonard
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 7, Pp n/a-n/a (2024)
Abstract Extracellular vesicles (EVs) play key roles in diverse biological processes, transport biomolecules between cells and have been engineered for therapeutic applications. A useful EV bioengineering strategy is to express engineered proteins on
Externí odkaz:
https://doaj.org/article/fa08fc19a02f4b398365b7e2ccda7e35
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Chimeric antigen receptor (CAR) T-cell therapy shows promise for treating liquid cancers and increasingly for solid tumors as well. While potential design strategies exist to address translational challenges, including the lack of unique tumor antige
Externí odkaz:
https://doaj.org/article/daa0a8a8db0b41cbb9c2873caca33b12
Autor:
Patrick S. Donahue, Joseph W. Draut, Joseph J. Muldoon, Hailey I. Edelstein, Neda Bagheri, Joshua N. Leonard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Engineering mammalian cellular functions requires a toolkit of orthogonal and well-characterized genetic components. Here the authors develop COMET: an ensemble of transcription factors, promoters, and accompanying models for the design and construct
Externí odkaz:
https://doaj.org/article/7ee29a59a9554e1ba69e92cbf22088a7
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Macrophage activation is tightly regulated to maintain immune homeostasis, yet activation is also heterogeneous. Here, the authors show that macrophages coordinate activation by partitioning into two phenotypes that can nonlinearly amplify collective
Externí odkaz:
https://doaj.org/article/5843764271434eebb99ebbcda964b4ae
Autor:
Michelle E. Hung, Joshua N. Leonard
Publikováno v:
Journal of Extracellular Vesicles, Vol 5, Iss 0, Pp 1-13 (2016)
Extracellular vesicles (EVs) mediate intercellular communication through transfer of RNA and protein between cells. Thus, understanding how cargo molecules are loaded and delivered by EVs is of central importance for elucidating the biological roles
Externí odkaz:
https://doaj.org/article/c02a57ef1a124e688ad8bdea7f032fcc
Autor:
Michelle E. Marcus, Joshua N. Leonard
Publikováno v:
Pharmaceuticals, Vol 6, Iss 5, Pp 659-680 (2013)
Many aspects of intercellular communication are mediated through “sending” and “receiving” packets of information via the secretion and subsequent receptor-mediated detection of biomolecular species including cytokines, chemokines, and even m
Externí odkaz:
https://doaj.org/article/8583b4342b704eae8d7bec2c8a4e0339
Autor:
Simrita Deol, Patrick S. Donahue, Roxanna E. Mitrut, Iva J. Hammitt-Kess, Jihae Ahn, Bin Zhang, Joshua N. Leonard
Autologous immune cell therapies are potentially curative, but cost and manufacturing complexity limit access. Off-the-shelf therapies may address these gaps, but further development is needed. The NK92 cell line has a natural killer-like phenotype,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd7bfaa274c02578279126c52ee1a8d
https://doi.org/10.1101/2023.05.13.540611
https://doi.org/10.1101/2023.05.13.540611
Autor:
Justin A. Peruzzi, Taylor F. Gunnels, Hailey I. Edelstein, Peilong Lu, David Baker, Joshua N. Leonard, Neha P. Kamat
Naturally generated lipid nanoparticles termed extracellular vesicles (EVs) hold significant promise as engineerable therapeutic delivery vehicles. However, active loading of protein cargo into EVs in a manner that is useful for delivery remains a ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc7e346d62ee99d806cb69113aca0305
https://doi.org/10.1101/2023.04.29.538810
https://doi.org/10.1101/2023.04.29.538810
Publikováno v:
Nat Chem Biol
Receptors enable cells to detect, process and respond to information about their environments. Over the past two decades, synthetic biologists have repurposed physical parts and concepts from natural receptors to engineer synthetic receptors. These t