Výsledky vyhledávání - "Joshua M. Ruch"

A phase I trial of cabozantinib and gemcitabine in advanced pancreatic cancer

Autor: David Bing Zhen, Jason E. Savage, Joshua M. Ruch, Kevin Camphausen, Diane M. Simeone, Kent A. Griffith, Mark M. Zalupski, Vaibhav Sahai, Edward J. Kim

Publikováno v: Investigational new drugs, vol 34, iss 6
Invest New Drugs

Background Cabozantinib and gemcitabine improve tumor control in pancreatic ductal adenocarcinoma (PDAC) in preclinical models through c-Met inhibition. We sought to determine the maximum tolerated dose (MTD) of this combination in patients with adva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef9611dd4d43344519c5cae73c7609f
https://escholarship.org/uc/item/8089j2w4

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A Phase II Study of Biweekly Cisplatin, Fixed-Dose-Rate Gemcitabine and Infusional 5-Fluorouracil in Patients With Metastatic Pancreatic and Biliary Cancers

Autor: Edward J. Kim, Elizabeth J. Davis, Mark M. Zalupski, Kevin McDonnell, Kent A. Griffith, Joshua M. Ruch

Publikováno v: American journal of clinical oncology, vol 41, iss 2

Objectives Combinations of gemcitabine, 5-fluorouracil (5-FU), and platinum have demonstrated improved outcomes compared with singlet chemotherapy in pancreatic and biliary cancers. This phase II study examined efficacy and safety of a novel schedule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b536a397033526846a680cefa2a65e4f
https://pubmed.ncbi.nlm.nih.gov/26535993

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Hedgehog signaling pathway and cancer therapeutics: progress to date

Autor: Joshua M. Ruch, Edward J. Kim

Publikováno v: Drugs. 73(7)

The Hedgehog (Hh) pathway is a developmental signaling pathway involved in numerous developmental processes, including determination of cell fate, patterning, proliferation, survival, and differentiation. While this pathway is silenced in most adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f2a7e6907e211dbda9762d76768610
https://pubmed.ncbi.nlm.nih.gov/23605693

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Contributors

Autor: Charles S. Abrams, Thomas C. Abshire, Suzanne A. Arinsburg, Scott T. Avecilla, Aleksandar M. Babic, Michael Bellone, Carolyn M. Bennett, Michael A. Briones, James B. Bussel, Wayne L. Chandler, Marie Csete, Adam C. Cuker, Melissa M. Cushing, Marie-Laure Desormeaux, Roger Y. Dodd, Amy L. Dunn, Richard O. Francis, Jennifer Garbaini, Yelena Z. Ginzberg, Raymond P. Goodrich, Cheryl A. Goss, Benjamin J. Greco, Jeanne E. Hendrickson, Christopher D. Hillyer, Eldad A. Hod, Heather A. Hume, Florencia G. Jalikis, Shawn M. Jobe, Casssandra D. Josephson, Matthew S. Karafin, Sadiqa Karim, Louis M. Katz, Christine L. Kempton, Debra A. Kessler, Devika Lal, Michele P. Lambert, Wendy Lim, Irina Knezevic Maramica, Susanne Marschner, Catherine E. Mcguinn, Shannon L. Meeks, Connie H. Miller, W. Beau Mitchell, Grace F. Monis, Theresa Nester, Huy Phu Pham, Eva D. Quinley, Hanna Rennert, Morayma Reyes, Anna-Sophie Rich, Mikhail Roshal, Joshua M. Ruch, William J. Savage, Andromachi Scaradavou, Joseph Schwartz, Beth H. Shaz, Patricia Shi, Suman Sood, Rona S. Weinberg, Connie M. Westhoff, Anne M. Winkler, Jiong Yan, James C. Zimring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b73514ff4a0bf6da6b10133c44f901d
https://doi.org/10.1016/b978-0-12-397164-7.01002-8

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Bleeding Disorders in Cancer Patients

Autor: Suman L. Sood, Joshua M. Ruch

Bleeding disorders are common in patients with cancer. The vasculature, platelet number and function and coagulation system may all be adversely affected by the malignancy and/or its treatments. While the cause of bleeding may be straightforward in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c621e243eb1ab1b996e3ece1d4b99b54
https://doi.org/10.1016/b978-0-12-397164-7.00119-1

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A phase I trial of cabozantinib (XL184) and gemcitabine in advanced pancreatic cancer

Autor: Vaibhav Sahai, Edward J. Kim, David B. Zhen, Mark M. Zalupski, Joshua M. Ruch, Meredith A. Morgan, Kent A. Griffith, Diane M. Simeone

Publikováno v: Journal of Clinical Oncology. 34:334-334

334 Background: Hepatocyte growth factor (HGF) and its receptor (c-Met) are activated in pancreatic ductal adenocarcinoma (PDAC). Preclinical data showed a combination of cabozantinib (cabo) and gemcitabine (gem) improved tumor control through inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::409aaa8defdf91a6ce92ca91a413fb09
https://doi.org/10.1200/jco.2016.34.4_suppl.334

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Evolving therapeutic paradigms for advanced prostate cancer

Autor: Joshua M, Ruch, Maha H, Hussain

Publikováno v: Oncology (Williston Park, N.Y.). 25(6)

Improving survival in metastatic castration-resistant prostate cancer (CRPC) is no longer an elusive goal. With the expansion of knowledge regarding the biology of the disease, we are witnessing a plethora of novel therapeutics that are undergoing te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d510cc63a9be72191a7f5d53ead436c
https://pubmed.ncbi.nlm.nih.gov/21717906

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Prediction of Venous Thromboembolism (VTE) in Patients with Pancreatic Cancer Using Clinical Data, Biomarkers, and VTE Risk Models

Autor: Thomas W. Wakefield, Emily Bellile, Suman L. Sood, Joshua M. Ruch, Michelle A. Anderson, Angela E. Hawley

Publikováno v: Blood. 120:3398-3398

Abstract 3398 INTRODUCTION: VTE is common in patients with cancer and causes significant morbidity and mortality. Clinical risk models and biomarkers including C-reactive protein (CRP), soluble P-selectin (sPsel), and D-dimer have been used to predic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7e9c8e9f7a16f993ff3453c975427ea
https://doi.org/10.1182/blood.v120.21.3398.3398

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Impact of Venous Thromboembolism (VTE) Prophylaxis and Risk Stratification with the Caprini Model in Hospitalized Patients with Cancer

Autor: Joshua M. Ruch, Vinita Bahl, Suman L. Sood, Hsou Mei Hu

Publikováno v: Blood. 120:364-364

Abstract 364 Introduction: VTE is a common complication in hospitalized medical patients and the role of pharmacologic anticoagulation prophylaxis is well-established. Patients with active malignancy are at higher risk for VTE during hospitalization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::410b872ea9c8ae6754f08ef3da75d35e
https://doi.org/10.1182/blood.v120.21.364.364

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Risk factors for venous thromboembolism (VTE) in outpatients with pancreatic cancer

Autor: Suman L. Sood, Michelle A. Anderson, Joshua M. Ruch

Publikováno v: Journal of Clinical Oncology. 30:e14578-e14578

e14578 Background: The incidence of VTE is increased in pancreatic cancer. Predictive models for cancer-associated VTE have been developed, but none specific for the pancreas. Our primary objective was to identify risk factors for VTE in outpatients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42fdcb5bc1d6eefc47268d919612ef22
https://doi.org/10.1200/jco.2012.30.15_suppl.e14578

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