Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Joshua M. Royal"'
Autor:
Jennifer K. DeMarco, Joshua M. Royal, William E. Severson, Jon D. Gabbard, Steve Hume, Josh Morton, Kelsi Swope, Carrie A. Simpson, John W. Shepherd, Barry Bratcher, Kenneth E. Palmer, Gregory P. Pogue
Publikováno v:
Vaccines, Vol 9, Iss 11, p 1346 (2021)
We developed a SARS-CoV-2 vaccine candidate (CoV-RBD121-NP) comprised of a tobacco mosaic virus-like nanoparticle conjugated to the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 fused to a human IgG1 Fc domain. CoV-RBD121-NP elicits
Externí odkaz:
https://doaj.org/article/d948abd924354895b2c5b1c46d082bd9
Autor:
Joshua M. Royal, Carrie A. Simpson, Alison A. McCormick, Amanda Phillips, Steve Hume, Josh Morton, John Shepherd, Youngjun Oh, Kelsi Swope, Jennifer L. DeBeauchamp, Richard J. Webby, Robert W. Cross, Viktoriya Borisevich, Thomas W. Geisbert, Jennifer K. Demarco, Barry Bratcher, Hugh Haydon, Gregory P. Pogue
Publikováno v:
Vaccines, Vol 9, Iss 11, p 1347 (2021)
Stable, effective, easy-to-manufacture vaccines are critical to stopping the COVID-19 pandemic resulting from the coronavirus SARS-CoV-2. We constructed a vaccine candidate CoV-RBD121-NP, which is comprised of the SARS-CoV-2 receptor-binding domain (
Externí odkaz:
https://doaj.org/article/43b61c27594a4cee8b9a7611a625c5e8
Autor:
Micaela A. Reeves, Joshua M. Royal, David A. Morris, Jessica M. Jurkiewicz, Nobuyuki Matoba, Krystal T. Hamorsky
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 576 (2021)
Epicertin (EPT) is a recombinant variant of the cholera toxin B subunit, modified with a C-terminal KDEL endoplasmic reticulum retention motif. EPT has therapeutic potential for ulcerative colitis treatment. Previously, orally administered EPT demons
Externí odkaz:
https://doaj.org/article/9059f402df6d4d4aad9515032ad0743a
Publikováno v:
Toxins, Vol 7, Iss 3, Pp 974-996 (2015)
Cholera, a waterborne acute diarrheal disease caused by Vibrio cholerae, remains prevalent in underdeveloped countries and is a serious health threat to those living in unsanitary conditions. The major virulence factor is cholera toxin (CT), which co
Externí odkaz:
https://doaj.org/article/06140fa852f0472fbd26ad9e75d310eb
Publikováno v:
Toxins, Vol 11, Iss 12, p 678 (2019)
Cholera toxin B subunit (CTB), a non-toxic homopentameric component of Vibrio cholerae holotoxin, is an oral cholera vaccine antigen that induces an anti-toxin antibody response. Recently, we demonstrated that a recombinant CTB variant with a Lys-Asp
Externí odkaz:
https://doaj.org/article/f05259913da74c6987ce665358833104
Autor:
Joshua M. Royal, Nobuyuki Matoba
Publikováno v:
Toxins, Vol 9, Iss 12, p 379 (2017)
Cholera toxin B subunit (CTB) is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and va
Externí odkaz:
https://doaj.org/article/129e62109ca44f73b9414a5dec5b2d2b
Autor:
Joshua M. Royal, David A. Morris, Krystal Teasley Hamorsky, Nobuyuki Matoba, Micaela A. Reeves
Publikováno v:
Process Biochemistry. 101:42-49
Here we describe refined methods for the isolation and detection of a KDEL-tagged, plant-produced recombinant cholera toxin B subunit (CTB) that exhibits unique mucosal wound healing activity. The protein was transiently overexpressed in Nicotiana be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f17f343cb1faf406b95b034a16e69580
https://doi.org/10.1016/j.procbio.2020.10.018
https://doi.org/10.1016/j.procbio.2020.10.018
Autor:
Gregory P. Pogue, Steve Hume, Jennifer K. DeMarco, Josh Morton, John W. Shepherd, Jon D. Gabbard, Joshua M. Royal, Kelsi Swope, Barry Bratcher, Kenneth E. Palmer, William Severson, Carrie A. Simpson
Publikováno v:
Vaccines
Vaccines, Vol 9, Iss 1346, p 1346 (2021)
Volume 9
Issue 11
Vaccines, Vol 9, Iss 1346, p 1346 (2021)
Volume 9
Issue 11
We developed a SARS-CoV-2 vaccine candidate (CoV-RBD121-NP) comprised of a tobacco mosaic virus-like nanoparticle conjugated to the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 fused to a human IgG1 Fc domain. CoV-RBD121-NP elicits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b329a7578b16d5aa6c0a5474182ec467
https://pubmed.ncbi.nlm.nih.gov/34835277
https://pubmed.ncbi.nlm.nih.gov/34835277
Autor:
Joshua M. Royal, David A. Morris, Krystal Teasley Hamorsky, Micaela A. Reeves, Jessica M. Jurkiewicz, Nobuyuki Matoba
Publikováno v:
Pharmaceutics
Volume 13
Issue 4
Pharmaceutics, Vol 13, Iss 576, p 576 (2021)
Volume 13
Issue 4
Pharmaceutics, Vol 13, Iss 576, p 576 (2021)
Epicertin (EPT) is a recombinant variant of the cholera toxin B subunit, modified with a C-terminal KDEL endoplasmic reticulum retention motif. EPT has therapeutic potential for ulcerative colitis treatment. Previously, orally administered EPT demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0555aa06f080f16039ef2a1315f9db
Publikováno v:
Process Biochem
Here we describe refined methods for the isolation and detection of a KDEL-tagged, plant-produced recombinant cholera toxin B subunit (CTB) that exhibits unique mucosal wound healing activity. The protein was transiently overexpressed in Nicotiana be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0880e284eed62352ee2f801f6e630973
https://pubmed.ncbi.nlm.nih.gov/33304198
https://pubmed.ncbi.nlm.nih.gov/33304198