Zobrazeno 1 - 10
of 670
pro vyhledávání: '"Joshua M. Hare"'
Autor:
Jessica R. Hoffman, Hyun-Ji Park, Sruti Bheri, Manu O. Platt, Joshua M. Hare, Sunjay Kaushal, Judith L. Bettencourt, Dejian Lai, Timothy C. Slesnick, William T. Mahle, Michael E. Davis
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107980- (2023)
Summary: Cardiac-derived c-kit+ progenitor cells (CPCs) are under investigation in the CHILD phase I clinical trial (NCT03406884) for the treatment of hypoplastic left heart syndrome (HLHS). The therapeutic efficacy of CPCs can be attributed to the r
Externí odkaz:
https://doaj.org/article/c98aba44087c46edbb4851a882473aa8
Autor:
Fakiha Firdaus, Manish Kuchakulla, Rehana Qureshi, Raul Ariel Dulce, Yash Soni, Derek J. Van Booven, Khushi Shah, Thomas Masterson, Omar Joel Rosete, Sanoj Punnen, Joshua M. Hare, Ranjith Ramasamy, Himanshu Arora
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-13 (2022)
Abstract Sustained oxidative stress in castration-resistant prostate cancer (CRPC) cells potentiates the overall tumor microenvironment (TME). Targeting the TME using colony-stimulating factor 1 receptor (CSF1R) inhibition is a promising therapy for
Externí odkaz:
https://doaj.org/article/e2dd2463f7454636b871a42fa1edf315
Autor:
Himanshu Arora, Rehana Qureshi, Kajal Khodamoradi, Deepa Seetharam, Madhumita Parmar, Derek J. Van Booven, Isabelle Catherine Issa, Robert Sackstein, Dolores Lamb, Joshua M. Hare, Ranjith Ramasamy
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-13 (2022)
Abstract Although testosterone deficiency (TD) may be present in one out of five men 40 years or older, the factors responsible for TD remain largely unknown. Leydig stem cells (LSCs) differentiate into adult Leydig cells (ALC) and produce testostero
Externí odkaz:
https://doaj.org/article/d4735d1d79fa46a685785e354d657a59
Autor:
Craig C. Morris, Jacob Ref, Satya Acharya, Kevin J. Johnson, Scott Squire, Tuschar Acharya, Tyler Dennis, Sherry Daugherty, Alice McArthur, Ikeotunye Royal Chinyere, Jen Watson Koevary, Joshua M. Hare, Jordan J. Lancaster, Steven Goldman, Ryan Avery
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract In swine models, there are well-established protocols for creating a closed-chest myocardial infarction (MI) as well as protocols for characterization of cardiac function with cardiac magnetic resonance (CMR). This methods manuscript outline
Externí odkaz:
https://doaj.org/article/0cced2d087ce4610a7ef56edfb43fb6f
Autor:
Ashraf El Fiky, Laarni Ibenana, Robert Anderson, Joshua M. Hare, Aisha Khan, Adrian P. Gee, Cliona Rooney, David H. McKenna, Joseph Gold, Linda Kelley, Martha S. Lundberg, Lisbeth A. Welniak, Robert Lindblad
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 6, Pp 2099-2110 (2021)
Abstract The Production Assistance for Cellular Therapies (PACT) Program, is funded and supported by the US Department of Health and Human Services’ National Institutes of Health (NIH) National Heart Lung and Blood Institute (NHLBI) to advance deve
Externí odkaz:
https://doaj.org/article/ff938c54c87c45968ca22d3530c8d620
Autor:
Monique Williams, Jose Manuel Condor Capcha, Camila Iansen Irion, Grace Seo, Guerline Lambert, Ali Kamiar, Keyvan Yousefi, Rosemeire Kanashiro‐Takeuchi, Lauro Takeuchi, Ali G. Saad, Armando Mendez, Keith A. Webster, Jeffrey J. Goldberger, Joshua M. Hare, Lina A. Shehadeh
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 17 (2022)
Background The pathways of diastolic dysfunction and heart failure with preserved ejection fraction driven by lipotoxicity with metabolic syndrome are incompletely understood. Thus, there is an urgent need for animal models that accurately mimic the
Externí odkaz:
https://doaj.org/article/432212ebf6704b49a53ed9538b43891e
Autor:
Eliyahu Kresch, Justin Achua, Russell Saltzman, Kajal Khodamoradi, Himanshu Arora, Emad Ibrahim, Oleksandr N. Kryvenko, Vania Wolff Almeida, Fakiha Firdaus, Joshua M. Hare, Ranjith Ramasamy
Publikováno v:
The World Journal of Men's Health, Vol 39, Iss 3, Pp 466-469 (2021)
Purpose: A pilot study to describe histopathological features of penile tissue of patients who recovered from symptomatic COVID-19 infection and subsequently developed severe erectile dysfunction (ED). Materials and Methods:Materials and Methods: Pe
Externí odkaz:
https://doaj.org/article/00fda45adad5445b93f8c7fa8e658904
Autor:
Thomas J. Povsic, Ricardo Sanz‐Ruiz, Andreu M. Climent, Roberto Bolli, Doris A. Taylor, Bernard J. Gersh, Philippe Menasché, Emerson C. Perin, Giulio Pompilio, Douwe E. Atsma, Lina Badimon, Anthony N. DeMaria, Joshua M. Hare, Timothy D. Henry, Stefan Janssens, Jens Kastrup, Daniele Torella, Jay H. Traverse, James T. Willerson, Francisco Fernández‐Avilés
Publikováno v:
ESC Heart Failure, Vol 8, Iss 3, Pp 2306-2309 (2021)
Abstract The concept that cell‐based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches
Externí odkaz:
https://doaj.org/article/aa0ac4175dff4a92ac246bdf889ab4ba
Autor:
Muthukumar Gunasekaran, Rachana Mishra, Progyaparamita Saha, David Morales, Wen-Chih Cheng, Arun R. Jayaraman, Jessica R. Hoffman, Lauran Davidson, Ling Chen, Aakash M. Shah, Gregory Bittle, Xuebin Fu, Antariksh Tulshyan, Mohamed Abdullah, Tami Kingsbury, Curt Civin, Peixin Yang, Michael E. Davis, Roberto Bolli, Joshua M. Hare, Sudhish Sharma, Sunjay Kaushal
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104656- (2022)
Summary: Successful cell therapy requires cells to resist the hostile ischemic myocardium, be retained to continue secreting cardioprotective growth factors/exosomes, and resist immunological host responses. Clinically relevant stem/progenitor cells
Externí odkaz:
https://doaj.org/article/cfa3170dcc4846bba20f01a55e64e98d
Autor:
Michael G. Rizzo, Thomas M. Best, Johnny Huard, Marc Philippon, Francis Hornicek, Zhenfeng Duan, Anthony J. Griswold, Lee D. Kaplan, Joshua M. Hare, Dimitrios Kouroupis
Publikováno v:
Cells, Vol 12, Iss 10, p 1421 (2023)
Osteoarthritis (OA) is the most common cause of disability worldwide among the elderly. Alarmingly, the incidence of OA in individuals less than 40 years of age is rising, likely due to the increase in obesity and post-traumatic osteoarthritis (PTOA)
Externí odkaz:
https://doaj.org/article/da1a1e0301104379838d5eaf94d8c064