Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Joshua M. Brockman"'
Autor:
Kwasi Adu-Berchie, Joshua M. Brockman, Yutong Liu, Tania W. To, David K. Y. Zhang, Alexander J. Najibi, Yoav Binenbaum, Alexander Stafford, Nikolaos Dimitrakakis, Miguel C. Sobral, Maxence O. Dellacherie, David J. Mooney
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Although adoptive T cell therapy provides the T cell pool needed for immediate tumor debulking, the infused T cells generally have a narrow repertoire for antigen recognition and limited ability for long-term protection. Here, we present a h
Externí odkaz:
https://doaj.org/article/c82858dc6c3249e0bed06dcad9fd4919
Autor:
David K. Y. Zhang, Kwasi Adu-Berchie, Siddharth Iyer, Yutong Liu, Nicoletta Cieri, Joshua M. Brockman, Donna Neuberg, Catherine J. Wu, David J. Mooney
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
‘Manufacturing CAR-T cells is a streamlined and highly regulated procedure involving T-cell-expansion and activation on a standardised platform. Here, the authors show that a personalized approach, taking the phenotypic attributes of individual pat
Externí odkaz:
https://doaj.org/article/f7959b99a7e04e99918762da2d538fbb
Autor:
Aaron Blanchard, J. Dale Combs, Joshua M. Brockman, Anna V. Kellner, Roxanne Glazier, Hanquan Su, Rachel L. Bender, Alisina S. Bazrafshan, Wenchun Chen, M. Edward Quach, Renhao Li, Alexa L. Mattheyses, Khalid Salaita
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The authors have recently developed molecular force microscopy (MFM) which uses fluorescence polarisation to measure cell-surface receptor force orientation. Here they show that structured illumination microscopes, which inherently use fluorescence p
Externí odkaz:
https://doaj.org/article/eb25c5882deb4c9a8bdcaa77f44d63b7
Autor:
Roxanne Glazier, Joshua M. Brockman, Emily Bartle, Alexa L. Mattheyses, Olivier Destaing, Khalid Salaita
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Podosomes are protrusive structures that coordinate diverse functions related to cell invasion, migration, bone resorption and immune surveillance. Here the authors integrate DNA nanotechnology with FLIM-FRET to demonstrate that podosomes apply pN in
Externí odkaz:
https://doaj.org/article/4a8b99e9937f47cb9e52b7240832a5e8
Autor:
Aaron Blanchard, J. Dale Combs, Joshua M. Brockman, Anna V. Kellner, Roxanne Glazier, Hanquan Su, Rachel L. Bender, Alisina S. Bazrafshan, Wenchun Chen, M. Edward Quach, Renhao Li, Alexa L. Mattheyses, Khalid Salaita
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/42ad264b3a24425daea024421061ec89
Autor:
Joshua M. Brockman, Khalid Salaita
Publikováno v:
Frontiers in Physics, Vol 7 (2019)
The cells and receptors of the immune system are mechanically active. Single molecule force spectroscopy, traction force microscopy, and molecular tension probe measurements all point to the importance of piconewton (pN) molecular forces in immune fu
Externí odkaz:
https://doaj.org/article/2eb621f1e3c3483e9cb980c52df2383a
Autor:
Yutong Liu, Kwasi Adu-Berchie, Joshua M. Brockman, Matthew Pezone, David K.Y. Zhang, Jingyi Zhou, Jason W. Pyrdol, Hua Wang, Kai W. Wucherpfennig, David J. Mooney
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(1)
Adoptive T cell transfer (ACT) therapies suffer from a number of limitations (e.g., poor control of solid tumors), and while combining ACT with cytokine therapy can enhance effectiveness, this also results in significant side effects. Here, we descri
Autor:
Kwasi Adu-Berchie, Joshua M. Brockman, Yutong Liu, David K.Y. Zhang, Alexander J. Najibi, Alexander Stafford, Miguel C. Sobral, Yoav Binenbaum, Maxence O. Dellacherie, David J. Mooney
Adoptive T cell therapy provides the T cell pool needed for immediate tumor debulking, but the infused T cells generally have a narrow repertoire for antigen recognition and limited ability for long-term protection. Here, we present a biomaterial pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37f3030095fe42b9ca7b7e66be395f89
https://doi.org/10.1101/2022.09.10.507437
https://doi.org/10.1101/2022.09.10.507437
Autor:
Victor Pui-Yan Ma, Yuesong Hu, Anna V. Kellner, Joshua M. Brockman, Arventh Velusamy, Aaron T. Blanchard, Brian D. Evavold, Ronen Alon, Khalid Salaita
Publikováno v:
Science advances. 8(8)
T cells defend against cancer and viral infections by rapidly scanning the surface of target cells seeking specific peptide antigens. This key process in adaptive immunity is sparked upon T cell receptor (TCR) binding of antigens within cell-cell jun
Autor:
Khalid Salaita, Jonathan P. K. Doye, Navoneel Sen, Yuxin Duan, Aaron T. Blanchard, Alisina Bazrafshan, Hanquan Su, Brooke Andrews, Hemani Chhabra, Travis A. Meyer, Joshua M. Brockman, R. Brian Dyer, Yonggang Ke
Publikováno v:
J Am Chem Soc
In single-molecule force spectroscopy (SMFS), a tethered molecule is stretched using a specialized instrument to study how macromolecules extend under force. One problem in SMFS is the serial and slow nature of the measurements, performed one molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6cc3981aeb851ef61b0e727ecf972f
https://ora.ox.ac.uk/objects/uuid:560ccf85-ddf7-418c-8d8f-25484a2e4635
https://ora.ox.ac.uk/objects/uuid:560ccf85-ddf7-418c-8d8f-25484a2e4635