Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Joshua M. Bradner"'
Autor:
Alyse N. Steves, Joshua M. Bradner, Kristen L. Fowler, Danielle Clarkson-Townsend, Brittany J. Gill, Adam C. Turry, W. Michael Caudle, Gary W. Miller, Anthony W.S. Chan, Charles A. Easley, IV
Publikováno v:
iScience, Vol 3, Iss , Pp 161-176 (2018)
Summary: Sperm counts have rapidly declined in Western males over the past four decades. This rapid decline remains largely unexplained, but exposure to environmental toxicants provides one potential explanation for this decline. Flame retardants are
Externí odkaz:
https://doaj.org/article/de8f81814dc24dc38614426756d6a31a
Autor:
Charles A. Easley, IV, Joshua M. Bradner, Amber Moser, Chelsea A. Rickman, Zachary T. McEachin, Megan M. Merritt, Jason M. Hansen, W. Michael Caudle
Publikováno v:
Stem Cell Research, Vol 14, Iss 3, Pp 347-355 (2015)
Environmental influences and insults by reproductive toxicant exposure can lead to impaired spermatogenesis or infertility. Understanding how toxicants disrupt spermatogenesis is critical for determining how environmental factors contribute to impair
Externí odkaz:
https://doaj.org/article/7b31d22e7e924e67a7e8118bdbd87909
Publikováno v:
Medical Sciences, Vol 4, Iss 3, p 13 (2016)
Our understanding of the contribution exposure to environmental toxicants has on neurological disease continues to evolve. Of these, Parkinson’s disease (PD) has been shown to have a strong environmental component to its etiopathogenesis. However,
Externí odkaz:
https://doaj.org/article/787635fc51ef4099917e46d782163499
Autor:
Vrinda Kalia, Megan M Niedzwiecki, Joshua M Bradner, Fion K Lau, Faith L Anderson, Meghan L Bucher, Katherine E Manz, Alexa Puri Schlotter, Zoe Coates Fuentes, Kurt D Pennell, Martin Picard, Douglas I Walker, William T Hu, Dean P Jones, Gary W Miller
Publikováno v:
PNAS Nexus. 1
Exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) has been associated with increased risk of Alzheimer's disease (AD), a disease also associated with hyperphosphorylated tau (p-tau) protein aggregation. We investigated whether exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b27f2875a18cdd810c14061355039e
https://doi.org/10.1093/pnasnexus/pgac050
https://doi.org/10.1093/pnasnexus/pgac050
Autor:
Douglas I. Walker, Hu Wt, Kalia, Coates Fuentes Z, Joshua M. Bradner, Fion K Lau, Martin Picard, Katherine E. Manz, Meghan L Bucher, Megan M. Niedzwiecki, Dean P. Jones, Gary W. Miller, Kurt D. Pennell
BackgroundThe formation of hyperphosphorylated tau (p-tau) protein tangles in neurons is a pathological marker of Alzheimer’s disease (AD). Exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) has been associated with increased risk of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eebb2a623cfed38ce91e40d866c6f90f
https://doi.org/10.1101/2021.06.14.448355
https://doi.org/10.1101/2021.06.14.448355
Autor:
Merry Chen, Monica Sharma, Fion K Lau, Dean P. Jones, Gary W. Miller, Michelle A. Johnson, Douglas I. Walker, Vrinda Kalia, Meghan L Bucher, Joshua M. Bradner
Publikováno v:
Toxicol Sci
The proper storage and release of monoamines contributes to a wide range of neuronal activity. Here, we examine the effects of altered vesicular monoamine transport in the nematode Caenorhabditis elegans. The gene cat-1 is responsible for the encodin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c035bc3278fa1ed5d28f221e9bac5d
https://pubmed.ncbi.nlm.nih.gov/33538833
https://pubmed.ncbi.nlm.nih.gov/33538833
Autor:
Carlie A. Black, Gary W. Miller, Kenny Igarza, Meghan L Bucher, Lauren Jonas, Joshua M. Bradner
Publikováno v:
Chem Res Toxicol
Impairments in the vesicular packaging of dopamine result in an accumulation of dopamine in the cytosol. Cytosolic dopamine is vulnerable to two metabolic processes - enzymatic catabolism and enzymatic- or auto-oxidation - that form toxic metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21af3df6ec5e2e6548190cca605a2a7e
https://pubmed.ncbi.nlm.nih.gov/33378168
https://pubmed.ncbi.nlm.nih.gov/33378168
Autor:
Meghan L Bucher, Michelle A. Johnson, Douglas I. Walker, Vrinda Kalia, Merry Chen, Monica Sharma, Gary W. Miller, Fion K Lau, Joshua M. Bradner, Dean P. Jones
The proper storage and release of monoamines contributes to a wide range of neuronal activity. Here, we examine the effects of altered vesicular monoamine transport in the nematodeC. elegans. The genecat-1is responsible for the encoding of the vesicu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::840ae1cde10795d67d3e1a8dc4b90c3a
https://doi.org/10.1101/2020.10.02.324095
https://doi.org/10.1101/2020.10.02.324095
Autor:
Yunshen Jiao, Bradley D. Pearce, Lasha S. Clarke, Alicia K. Smith, Sudeshna Paul, Jennifer G. Mulle, Anne L. Dunlop, Timothy D. Read, Elizabeth J. Corwin, Joshua M. Bradner, Nikolay Patrushev, Carol J. R. Hogue, Allison Hankus
Publikováno v:
Am J Reprod Immunol
PROBLEM: Disruption in homeostatic feedback loops between inflammatory mediators and the hypothalamic-pituitary-adrenal (HPA) axis is a key mechanism linking chronic stress to inflammation and adverse health outcomes, including those occurring during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0682b47235203faf4b5bdb7d380f743
https://doi.org/10.1111/aji.13252
https://doi.org/10.1111/aji.13252
Autor:
Danielle Clarkson-Townsend, Alyse N. Steves, Charles A. Easley, Gary W. Miller, W. Michael Caudle, Adam C. Turry, Anthony W.S. Chan, Ian Bachli, Joshua M. Bradner, Brittany Gill
Publikováno v:
Systems Biology in Reproductive Medicine. 64:225-239
Per- and polyfluoroalkyl substances (PFASs) represent a highly ubiquitous group of synthetic chemicals used in products ranging from water and oil repellents and lubricants to firefighting foam. These substances can enter and accumulate in multiple t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2549711f607f9653b4030546735645fd
https://doi.org/10.1080/19396368.2018.1481465
https://doi.org/10.1080/19396368.2018.1481465