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pro vyhledávání: '"Joshua M. Blose"'
Autor:
Kaethe N. Leonard, Joshua M. Blose
Publikováno v:
PeerJ, Vol 6, p e4236 (2018)
Osmolytes and macromolecular crowders have the potential to influence the stability of secondary structure motifs and alter preferences for conserved nucleic acid sequences in vivo. To further understand the cellular function of RNA we observed the e
Externí odkaz:
https://doaj.org/article/e7d62fd7f39f4652be1772f40df1e470
Autor:
Michelle E. Whittum, Joshua M. Blose
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. :1-15
Osmolytes have the potential to affect the stability of secondary structure motifs and alter preferences for conserved nucleic acid sequences in the cell. To contribute to the understanding of the in vivo function of RNA we observed the effects of di
Autor:
Joshua M. Blose, Kaethe N. Leonard
Publikováno v:
PeerJ
PeerJ, Vol 6, p e4236 (2018)
PeerJ, Vol 6, p e4236 (2018)
Osmolytes and macromolecular crowders have the potential to influence the stability of secondary structure motifs and alter preferences for conserved nucleic acid sequences in vivo. To further understand the cellular function of RNA we observed the e
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 36(11)
In the cell, nearly 40% of the volume is occupied by macromolecular crowding agents and smaller osmolytes accumulate in response to environmental stresses. Of particular interest is the influence of osmolytes on the transition of the right-handed B-D
Autor:
Steve P. Meisburger, Suzette A. Pabit, Joshua M. Blose, Lois Pollack, Li Li, Christopher D. W. Jones
Publikováno v:
Biochemistry. 50:8540-8547
Osmolytes are small, chemically diverse, organic solutes that function as an essential component of cellular stress response. Protecting osmolytes enhance protein stability via preferential exclusion, and nonprotecting osmolytes, such as urea, destab
Autor:
Joshua M. Blose, Vinod K. Misra, Narayanan Veeraraghavan, David J. Proctor, Philip C. Bevilacqua
Publikováno v:
Journal of the American Chemical Society. 131:8474-8484
Hairpins are common RNA secondary structures that play multiple roles in nature. Tetraloops are the most frequent RNA hairpin loops and are often phylogenetically conserved. For both the UNCG and GNRA families, CG closing base pairs (cbps) confer exc
Autor:
Philip C. Bevilacqua, Joshua M. Blose
Publikováno v:
Annual Review of Physical Chemistry. 59:79-103
Most RNA comprises one strand and therefore can fold back on itself to form complex structures. At the heart of these structures is the hairpin, which is composed of a stem having Watson-Crick base pairing and a loop wherein the backbone changes dire
Autor:
Yukiko Stranger-Jones, Chad A. Griffith, Joshua M. Blose, Jason D. Long, Kelly A. Klapec, Vasiliy Sim, Allison C. Zyra, Martin J. Serra, Michelle L. Manni
Publikováno v:
Biochemistry. 46:15123-15135
Fifty-nine RNA duplexes containing single-nucleotide bulge loops were optically melted in 1 M NaCl, and the thermodynamic parameters DeltaH degrees, DeltaS degrees, DeltaG 37 degrees, and TM for each sequence were determined. Sequences from this stud
Publikováno v:
Biochemistry. 51(46)
The protein kinase PKR is a key factor in innate immunity.1 In the presence of long stretches of A-form dsRNA, PKR is activated to undergo autophosphorylation.2,3 Once activated, PKR phosphorylates translation initiation factor eIF-2α, which blocks
Autor:
Joshua M. Blose, Christopher D. W. Jones, Li Li, Steve P. Meisburger, Lois Pollack, Suzette A. Pabit
Publikováno v:
Biophysical Journal. 100(3)
Osmolytes, which function as a vital component of the cellular stress response, are small, chemically diverse, intracellular organic solutes. Protecting osmolytes enhance protein stability via preferential exclusion, where denaturation of the protein