Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joshua M Scurll"'
Autor:
Madison Bolger-Munro, Kate Choi, Joshua M Scurll, Libin Abraham, Rhys S Chappell, Duke Sheen, May Dang-Lawson, Xufeng Wu, John J Priatel, Daniel Coombs, John A Hammer, Michael R Gold
Publikováno v:
eLife, Vol 8 (2019)
When B cells encounter antigens on the surface of an antigen-presenting cell (APC), B cell receptors (BCRs) are gathered into microclusters that recruit signaling enzymes. These microclusters then move centripetally and coalesce into the central supr
Externí odkaz:
https://doaj.org/article/495108e2d3d348008c7a1f7e3b66fd17
Autor:
Nina E. Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O’Toole, Elizabeth Whalen, Peter W. Y. Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E. Atkinson, Jason Baardsnes, Liam J. Worrall, Duncan Browman, Emma E. Smith, Priya Baichoo, Chi Wing Cheng, Joy Guedia, Sohyeong Kang, Abhishek Mukhopadhyay, Lisa Newhook, Anders Ohrn, Prajwal Raghunatha, Matteo Zago-Schmitt, Joseph D. Schrag, Joel Smith, Patricia Zwierzchowski, Joshua M. Scurll, Vincent Fung, Sonia Black, Natalie C. J. Strynadka, Michael R. Gold, Leonard G. Presta, Gordon Ng, Surjit Dixit
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cyt
Externí odkaz:
https://doaj.org/article/8a871ad93e594eeba832492229b1329b
Autor:
Davide Tortora, Morgan E. Roberts, Gunjan Kumar, Sudha S. Kotapalli, Elie Ritch, Joshua M. Scurll, Brian McConeghy, Sunita Sinha, Alexander W. Wyatt, Peter C. Black, Mads Daugaard
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106525- (2023)
Summary: Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor central in the regulation of key cellular processes including cell metabolism, tissue differentiation, and regulation of the immune system. PPARγ is required fo
Externí odkaz:
https://doaj.org/article/f77ff7431c4342bdb81350390eef33b5
Autor:
Mang Zhu, Thibault Mayor, Yeou Mei Ling, Lawrence P. McIntosh, Lok Tin Hui, Yossef Av-Gay, Joshua M. Scurll, Libin Abraham, Joseph D. Chao, Jennifer M. Bui, Keng C. Chou, Mary Ko, Florian Heinkel, Michael R. Gold, Haoran Li, Horacio Bach, Jason C. Rogalski, Jörg Gsponer
Publikováno v:
Proceedings of the National Academy of Sciences. 116:16326-16331
Phase separation drives numerous cellular processes, ranging from the formation of membrane-less organelles to the cooperative assembly of signaling proteins. Features such as multivalency and intrinsic disorder that enable condensate formation are f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb3ab37c0efec29483efd20faade945
https://doi.org/10.1073/pnas.1820683116
https://doi.org/10.1073/pnas.1820683116
Autor:
Libin Abraham, John A. Hammer, Daniel Coombs, Michael R. Gold, John J. Priatel, Joshua M. Scurll, Duke Sheen, Kate Choi, Xufeng Wu, May Dang-Lawson, Madison Bolger-Munro, Rhys Chappell
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
When B cells encounter antigens on the surface of an antigen-presenting cell (APC), B cell receptors (BCRs) are gathered into microclusters that recruit signaling enzymes. These microclusters then move centripetally and coalesce into the central supr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf39290b1824622a4a4e25345bce749
https://doi.org/10.7554/elife.44574
https://doi.org/10.7554/elife.44574
Autor:
Daniel Coombs, Rhys Chappell, Xufeng Wu, John A. Hammer, Joshua M. Scurll, Duke Sheen, Kate Choi, Libin Abraham, Michael R. Gold, May Dang-Lawson, John J. Priatel, Madison Bolger-Munro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b00b04a3af9b2063864cf2191b4732f
https://doi.org/10.7554/elife.44574.045
https://doi.org/10.7554/elife.44574.045
Autor:
Daniel Coombs, Michael R. Gold, Reza Tafteh, Keng C. Chou, Da Wei Zheng, Joshua M. Scurll, Libin Abraham
Clustering of proteins is crucial for many cellular processes and can be imaged at nanoscale resolution using single-molecule localization microscopy (SMLM). Ideally, molecular clustering in regions of interest (ROIs) from SMLM images would be assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4793b86a442d3242b4e63053520b47a1
https://doi.org/10.1101/515627
https://doi.org/10.1101/515627
Autor:
Kate Choi, May Dang-Lawson, Daniel Coombs, Michael R. Gold, Joshua M. Scurll, Duke Sheen, Libin Abraham, Xufeng Wu, John A. Hammer, John J. Priatel, Madison Bolger-Munro, Rhys Chappell
When B cells encounter antigens on the surface of an antigen-presenting cell (APC), B cell receptors (BCRs) are gathered into microclusters that recruit signaling enzymes. These microclusters then move centripetally and coalesce into the central supr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af92fb88b61404888b84cfed264a5726
https://doi.org/10.1101/490698
https://doi.org/10.1101/490698
Autor:
Libin Abraham, Joshua M Scurll, Reza Tafteh, Henry Y Lu, Rebeca Cardim Falcão, Keng C Chou, Daniel C Coombs, Michael R Gold
Publikováno v:
The Journal of Immunology. 206:63.16-63.16
Marginal zone (MZ) B cells exist in a partially-activated ‘primed’ state but the molecular basis for this priming is not fully understood. We found that MZ B cells exhibit greater antigen-independent ‘tonic’ BCR signaling than naïve follicul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e63cd0be4531b6364fe05c455a95ca1
https://doi.org/10.4049/jimmunol.206.supp.63.16
https://doi.org/10.4049/jimmunol.206.supp.63.16
Autor:
H. T. Law, Joshua M. Scurll, Stephanie R. Shames, Wanyin Deng, Leonard J. Foster, Roland Scholz, Joris van der Heijden, Carmen L. de Hoog, Andrew S. Santos, Robyn J. Law, Julian A. Guttman, Yuling Li, Matthew A. Croxen, B. Brett Finlay
Publikováno v:
Journal of Proteome Research. 15:1613-1622
Enteropathogenic and enterohemorrhagic Escherichia coli cause enteric diseases resulting in significant morbidity and mortality worldwide. These pathogens remain extracellular and translocate a set of type III secreted effector proteins into host cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b1661c2431198a6cc26181305d1fb4
https://doi.org/10.1021/acs.jproteome.6b00074
https://doi.org/10.1021/acs.jproteome.6b00074