Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Joshua M Buckler"'
Autor:
Shan Wen, Rowan Flynn, Bo Jiang, Nagadhara Dronadula, Kun Qian, Chongren Tang, Joshua M Buckler, Helén L. Dichek, David A. Dichek
Publikováno v:
Molecular Therapy. 19:1833-1841
Expression of atheroprotective genes in the blood vessel wall is potentially an effective means of preventing or reversing atherosclerosis. Development of this approach has been hampered by lack of a suitable gene-transfer vector. We used a helper-de
Publikováno v:
Molecular Therapy. 18(12):2121-2129
Arterial endothelial cells (EC) are attractive targets for gene therapy of atherosclerosis because they are accessible to hematogenous and catheter-based vector delivery and overlie atherosclerotic plaques. Vector-mediated expression'in EC'of protein
Autor:
Rowan Flynn, Jordan Kho, David A. Dichek, Nagadhara Dronadula, Shinji Tanaka, Joshua M Buckler, Liang Du, Zhilong Jiang
Publikováno v:
Gene therapy
The success of gene therapy hinges on achievement of adequate transgene expression. To ensure high transgene expression, many gene-therapy vectors include highly active virus-derived transcriptional elements. Other vectors include tissue-specific euk
Autor:
Clifford Tom, Kun Qian, Ian Luttrell, Anton S. McCourtie, Philip G. Massey, Kanchan Chitaley, Joshua M Buckler, Bo Jiang, Shan Wen, April Stempien-Otero, David A. Dichek, Shinji Tanaka
Publikováno v:
Thrombosis and haemostasis. 102(5)
SummaryUrokinase-type plasminogen activator (uPA) is expressed at increased levels in stenotic, atherosclerotic human arteries. However, the biological roles of uPA in the artery wall are poorly understood. Previous studies associate uPA with both ac
Autor:
Peter J. Cawley, Michael A. Chen, Francis Kim, Edward A. Gill, Joshua M Buckler, Pathmaja Paramsothy
Publikováno v:
Circulation. 118
Real-time 3D transesophageal echo (RT3D TEE) is a novel technology whereby RT3D rendering of ultrasound images is performed resulting in unique views of cardiac structures. We have presented initial data reporting the incidence of optimal en face vis
Autor:
Shufang Gu, Yuechun Shen, Peter F. Bodary, Joshua M. Buckler, Alyssa H. Hasty, Daniel T. Eitzman
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 25(8)
Objective— The direct role of leptin in vascular disease remains controversial. The objective of this study was to examine the effects of leptin treatment on atherosclerosis and thrombosis in atherosclerotic-prone mice. Methods and Results— Sixte