Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Joshua M Akey"'
Autor:
Jessica M. Hoffman, M. Katherine Tolbert, Daniel E. L. Promislow, The Dog Aging Project Consortium, Joshua M Akey, Brooke Benton, Elhanan Borenstein, Marta G Castelhano, Amanda E Coleman, Kate E Creevy, Kyle Crowder, Matthew D Dunbar, Virginia R Fajt, Annette L Fitzpatrick, Unity Jeffery, Erica C Jonlin, Matt Kaeberlein, Elinor K Karlsson, Kathleen F Kerr, Jonathan M Levine, Jing Ma, Robyn L McClelland, Audrey Ruple, Stephen M Schwartz, Sandi Shrager, Noah Snyder-Mackler, Silvan R Urfer, Benjamin S Wilfond
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Osteoarthritis (OA) is one of the most prevalent age-related chronic conditions that afflict companion dogs, and multiple joint supplements are available to prevent or treat OA, though the efficacy of these treatments is controversial. While the demo
Externí odkaz:
https://doaj.org/article/fa849b279a3a4e0784fe4481a3c81bdd
Autor:
Chadi M Saad-Roy, Nimalan Arinaminpathy, Ned S Wingreen, Simon A Levin, Joshua M Akey, Bryan T Grenfell
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007892 (2020)
Seasonal influenza A viruses of humans evolve rapidly due to strong selection pressures from host immune responses, principally on the hemagglutinin (HA) viral surface protein. Based on mouse transmission experiments, a proposed mechanism for immune
Externí odkaz:
https://doaj.org/article/4beb7a1f06af4933ae769a0b78caf718
Autor:
Aaron B Wolf, Joshua M Akey
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007349 (2018)
The complete sequencing of archaic and modern human genomes has revolutionized the study of human history and evolution. The application of paleogenomics has answered questions that were beyond the scope of archaeology alone-definitively proving admi
Externí odkaz:
https://doaj.org/article/fcca811616ab4b8da6966efd94d554b1
Autor:
Rylee Matheson, Courtney L. Sexton, Catherine F. Wise, Janice O’Brien, Amber J. Keyser, Mandy Kauffman, Matthew D. Dunbar, DAP Consortium, Joshua M. Akey, Brooke Benton, Elhanan Borenstein, Marta G. Castelhano, Amanda E. Coleman, Kate E. Creevy, Kyle Crowder, Virginia R. Fajt, Annette L. Fitzpatrick, Unity Jeffery, Erica C Jonlin, Matt Kaeberlein, Elinor K. Karlsson, Kathleen F. Kerr, Jonathan M. Levine, Jing Ma, Robyn L McClelland, Daniel E.L. Promislow, Audrey Ruple, Stephen M. Schwartz, Sandi Shrager, Noah Snyder-Mackler, M. Katherine Tolbert, Silvan R. Urfer, Benjamin S. Wilfond
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionCompanion animals offer a unique opportunity to investigate risk factors and exposures in our shared environment. Passive sampling techniques have proven effective in capturing environmental exposures in dogs and humans.MethodsIn a pilot
Externí odkaz:
https://doaj.org/article/d026a8041d8a468c8110320df8400a04
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004427 (2014)
Chromatin accessibility is an important functional genomics phenotype that influences transcription factor binding and gene expression. Genome-scale technologies allow chromatin accessibility to be mapped with high-resolution, facilitating detailed a
Externí odkaz:
https://doaj.org/article/52122d90a349445ea27e8e109e14da11
Autor:
Timothy D O'Connor, Adam Kiezun, Michael Bamshad, Stephen S Rich, Joshua D Smith, Emily Turner, NHLBIGO Exome Sequencing Project, ESP Population Genetics, Statistical Analysis Working Group, Suzanne M Leal, Joshua M Akey
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e65834 (2013)
Advances in next-generation sequencing technology have enabled systematic exploration of the contribution of rare variation to Mendelian and complex diseases. Although it is well known that population stratification can generate spurious associations
Externí odkaz:
https://doaj.org/article/73c9803e1e2e43ad8c0ff68ad219753a
Autor:
Rasika A Mathias, Wenqing Fu, Joshua M Akey, Hannah C Ainsworth, Dara G Torgerson, Ingo Ruczinski, Susan Sergeant, Kathleen C Barnes, Floyd H Chilton
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44926 (2012)
Long chain polyunsaturated fatty acids (LC-PUFAs) are essential for brain structure, development, and function, and adequate dietary quantities of LC-PUFAs are thought to have been necessary for both brain expansion and the increase in brain complexi
Externí odkaz:
https://doaj.org/article/92f6be45a49443a288806bc73de4a571
Autor:
Jacob A Tennessen, Joshua M Akey
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002127 (2011)
Few genetic differences between human populations conform to the classic model of positive selection, in which a newly arisen mutation rapidly approaches fixation in one lineage, suggesting that adaptation more commonly occurs via moderate changes in
Externí odkaz:
https://doaj.org/article/bc423f7bafa840b897d979372ec61668
Autor:
Abigail Bigham, Marc Bauchet, Dalila Pinto, Xianyun Mao, Joshua M Akey, Rui Mei, Stephen W Scherer, Colleen G Julian, Megan J Wilson, David López Herráez, Tom Brutsaert, Esteban J Parra, Lorna G Moore, Mark D Shriver
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001116 (2010)
High-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric pressure) exerts severe physiological stress on the human body. Two high-altitude regions where humans have lived for millennia are the Andean Altiplano and the Tibeta
Externí odkaz:
https://doaj.org/article/39cb3d049f7b49aca867b424e226bc0d
Autor:
James Ronald, Joshua M Akey
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e678 (2007)
Understanding the evolutionary forces that influence patterns of gene expression variation will provide insights into the mechanisms of evolutionary change and the molecular basis of phenotypic diversity. To date, studies of gene expression evolution
Externí odkaz:
https://doaj.org/article/00ffb4ccc0c848a8867f72505511c852