Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joshua M Adams"'
Publikováno v:
Cells, Vol 11, Iss 7, p 1155 (2022)
N-Glycanase 1 (NGLY1) is a cytosolic enzyme involved in removing N-linked glycans of misfolded N-glycoproteins and is considered to be a component of endoplasmic reticulum-associated degradation (ERAD). The 2012 identification of recessive NGLY1 muta
Externí odkaz:
https://doaj.org/article/1c12886607cd423a959955b0c22fd2df
Autor:
Antonio Galeone, Joshua M Adams, Shinya Matsuda, Maximiliano F Presa, Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Hiroto Hirayama, Thomas Vaccari, Tadashi Suzuki, Cathleen M Lutz, Markus Affolter, Aamir Zuberi, Hamed Jafar-Nejad
Publikováno v:
eLife, Vol 9 (2020)
During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme N-glycanase 1 (NGLY1) is proposed to remove N-glycans from misfolded N-glycoproteins after their retrotranslocation from the ER to the cytosol. We previously reported
Externí odkaz:
https://doaj.org/article/7f96a57cf41d4be982d6c1682f81ca7d
Autor:
Joshua M. Adams, Hamed Jafar-Nejad
Publikováno v:
Biomolecules, Vol 9, Iss 10, p 608 (2019)
The Notch signaling pathway plays major roles in organ development across animal species. In the mammalian liver, Notch has been found critical in development, regeneration and disease. In this review, we highlight the major advances in our understan
Externí odkaz:
https://doaj.org/article/9990710dd3c649719a3d5b9d27faed78
Autor:
Mario F. Lopez, Kari A. Huppert, Nima Niknejad, Milton J. Finegold, Eumenia Costa da Cunha Castro, Stacey S. Huppert, Hamed Jafar-Nejad, Sanjay Subramanian, Joshua M Adams, Neda Zarrin-Khameh
Publikováno v:
Hepatology
Background and aims Alagille syndrome (ALGS) is a multisystem developmental disorder characterized by bile duct (BD) paucity, caused primarily by haploinsufficiency of the Notch ligand jagged1. The course of the liver disease is highly variable in AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354feda5393498285f4f3c42545c5270
https://doi.org/10.1002/hep.30912
https://doi.org/10.1002/hep.30912
Autor:
Yuriko Tachida, Ashutosh Pandey, Seung Yeop Han, Hamed Jafar-Nejad, Joshua M Adams, Antonio Galeone, Maximiliano Presa, Hiroto Hirayama, Cathleen M. Lutz, Thomas Vaccari, Aamir Zuberi, Tadashi Suzuki, Markus Affolter, Shinya Matsuda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd0a120e7b22d00fbf497820546fb3b8
https://doi.org/10.7554/elife.55596.sa2
https://doi.org/10.7554/elife.55596.sa2
Autor:
Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Shinya Matsuda, Antonio Galeone, Aamir Zuberi, Markus Affolter, Maximiliano Presa, Tadashi Suzuki, Thomas Vaccari, Hiroto Hirayama, Cathleen M. Lutz, Hamed Jafar-Nejad, Joshua M Adams
Publikováno v:
eLife
eLife Sciences Publications, Ltd
eLife, Vol 9 (2020)
eLife Sciences Publications, Ltd
eLife, Vol 9 (2020)
During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzymeN-glycanase 1 (NGLY1) is proposed to removeN-glycans from misfoldedN-glycoproteins after their retrotranslocation from the ER to the cytosol. We previously reported tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b54b7d6ac647faccc168f633358479
https://pubmed.ncbi.nlm.nih.gov/32720893
https://pubmed.ncbi.nlm.nih.gov/32720893
Autor:
Hamed Jafar-Nejad, Joshua M Adams
Publikováno v:
Gastroenterology
Background & Aims Alagille syndrome is a genetic disorder characterized by cholestasis, ocular abnormalities, characteristic facial features, heart defects, and vertebral malformations. Most cases are associated with mutations in JAGGED1 (JAG1), whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554529e011fd4406d98885514d751294
https://doi.org/10.1053/j.gastro.2018.02.007
https://doi.org/10.1053/j.gastro.2018.02.007
Autor:
Hamed Jafar-Nejad, Joshua M Adams
Publikováno v:
Biomolecules, Vol 9, Iss 10, p 608 (2019)
Biomolecules
Biomolecules
The Notch signaling pathway plays major roles in organ development across animal species. In the mammalian liver, Notch has been found critical in development, regeneration and disease. In this review, we highlight the major advances in our understan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b47c14d0df0fea0016a3bc98b2fa3d9
https://www.mdpi.com/2218-273X/9/10/608
https://www.mdpi.com/2218-273X/9/10/608
Autor:
Hamed Jafar-Nejad, Joshua M Adams
Publikováno v:
J Vis Exp
Mouse is broadly used as a model organism to study biliary diseases. To evaluate the development and function of the biliary system, various techniques are used, including serum chemistry, histological analysis, and immunostaining for specific marker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5789bf1a7b9e258992d41245d73b6297
https://doi.org/10.3791/59587
https://doi.org/10.3791/59587
Autor:
Stanley A. Schwartz, Jeffery Martinez, Zale P. Bernstein, Anardi Agosto-Mojica, Jessica L. Reynolds, Neha Singh, Donald E. Sykes, Ravikumar Aalinkeel, Chiu-bin Hsiao, Joshua M Adams, Bindukumar Nair, Supriya D. Mahajan
Publikováno v:
Biochemical and biophysical research communications. 396(2)
Allelic variants of the genes for chemokine receptors and their natural ligands, the chemokines, and cytokines can affect HIV-1 disease progression. This study investigates the level of expression of the CCR5-Delta32, CCR2b-641, RANTES In1.1C, SDF-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdd8169b2fa2a6e61cc3af6eded7941
https://pubmed.ncbi.nlm.nih.gov/20416280
https://pubmed.ncbi.nlm.nih.gov/20416280