Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Joshua M, Weiss"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
During tumor progression, cancer cells contact different neighboring cell types, but it is unclear how these interactions affect cancer cell behavior. Here, the authors use spatially resolved transcriptomics and single-cell RNA-seq to study the role
Externí odkaz:
https://doaj.org/article/2ecde4c51693444e848693a8ceaca4c3
Autor:
Joshua M Weiss, Dianne Lumaquin-Yin, Emily Montal, Shruthy Suresh, Carl S Leonhardt, Richard M White
Publikováno v:
eLife, Vol 11 (2022)
Cancer cells exist in a complex ecosystem with numerous other cell types in the tumor microenvironment (TME). The composition of this tumor/TME ecosystem will vary at each anatomic site and affects phenotypes such as initiation, metastasis, and drug
Externí odkaz:
https://doaj.org/article/b7e03c26613d4f42a9c7d82a0b2778e8
Autor:
Dianne Lumaquin, Eleanor Johns, Emily Montal, Joshua M Weiss, David Ola, Abderhman Abuhashem, Richard M White
Publikováno v:
eLife, Vol 10 (2021)
Lipid droplets are lipid storage organelles found in nearly all cell types from adipocytes to cancer cells. Although increasingly implicated in disease, current methods to study lipid droplets in vertebrate models rely on static imaging or the use of
Externí odkaz:
https://doaj.org/article/1a5971567bd6400b87dbe45c2019ea87
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
During tumor progression, cancer cells come into contact with various non-tumor cell types, but it is unclear how tumors adapt to these new environments. Here, we integrate spatially resolved transcriptomics, single-cell RNA-seq, and single-nucleus R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b4b82ac2243a50780e3d13f732431e
https://doaj.org/article/2ecde4c51693444e848693a8ceaca4c3
https://doaj.org/article/2ecde4c51693444e848693a8ceaca4c3
Autor:
Carl S Leonhardt, Shruthy Suresh, Emily Montal, Dianne Lumaquin-Yin, Joshua M Weiss, Richard M White
Publikováno v:
eLife. 11
Cancer cells exist in a complex ecosystem with numerous other cell types in the tumor microenvironment (TME). The composition of this tumor/TME ecosystem will vary at each anatomic site and affects phenotypes such as initiation, metastasis, and drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65dfb843f9370f6df7e00890ab50f825
https://doi.org/10.7554/elife.69703
https://doi.org/10.7554/elife.69703
Autor:
Joshua M. Weiss, Miranda V. Hunter, Nelly M. Cruz, Arianna Baggiolini, Mohita Tagore, Yilun Ma, Sandra Misale, Michelangelo Marasco, Theresa Simon-Vermot, Nathaniel R. Campbell, Felicity Newell, James S. Wilmott, Peter A. Johansson, John F. Thompson, Georgina V. Long, John V. Pearson, Graham J. Mann, Richard A. Scolyer, Nicola Waddell, Emily D. Montal, Ting-Hsiang Huang, Philip Jonsson, Mark T.A. Donoghue, Christopher C. Harris, Barry S. Taylor, Tianhao Xu, Ronan Chaligné, Pavel V. Shliaha, Ronald Hendrickson, Achim A. Jungbluth, Cecilia Lezcano, Richard Koche, Lorenz Studer, Charlotte E. Ariyan, David B. Solit, Jedd D. Wolchok, Taha Merghoub, Neal Rosen, Nicholas K. Hayward, Richard M. White
Publikováno v:
Weiss, J M, Hunter, M V, Cruz, N M, Baggiolini, A, Tagore, M, Ma, Y, Misale, S, Marasco, M, Simon-Vermot, T, Campbell, N R, Newell, F, Wilmott, J S, Johansson, P A, Thompson, J F, Long, G V, Pearson, J V, Mann, G J, Scolyer, R A, Waddell, N, Montal, E D, Huang, T H, Jonsson, P, Donoghue, M T A, Harris, C C, Taylor, B S, Xu, T, Chaligné, R, Shliaha, P V, Hendrickson, R, Jungbluth, A A, Lezcano, C, Koche, R, Studer, L, Ariyan, C E, Solit, D B, Wolchok, J D, Merghoub, T, Rosen, N, Hayward, N K & White, R M 2022, ' Anatomic position determines oncogenic specificity in melanoma ', Nature, vol. 604, pp. 354-361 . https://doi.org/10.1038/s41586-022-04584-6
Nature
Nature
Oncogenic alterations to DNA are not transforming in all cellular contexts1,2. This may be due to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic position as a major determinant of why cells respond to specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b39395de5cccb872bc76acd0f99b36d
https://portal.findresearcher.sdu.dk/da/publications/fc93f265-733a-47a2-81d0-e175a3bb1f60
https://portal.findresearcher.sdu.dk/da/publications/fc93f265-733a-47a2-81d0-e175a3bb1f60
Autor:
Emily Montal, Sarah C. Perlee, Theresa Simon-Vermot, Scott J. Callahan, Barry S. Taylor, Tuan Trieu, Ekta Khurana, Richard M. White, Yujie Fan, Sam E. Tischfield, Ting-Hsiang Huang, Yilun Ma, Shruthy Suresh, Lorenz Studer, Satish K. Tickoo, Richard Koche, Arianna Baggiolini, Nathalie Saurat, Miranda V. Hunter, Joshua M. Weiss, Ryan M. Walsh, Nathaniel R. Campbell, Mohita Tagore, Travis J. Hollmann
Publikováno v:
Science. 373
Chromatin state and oncogenic competence Although specific DNA mutations can lead to tumor generation, they are not transforming in all cellular contexts. This may be due to the intrinsic transcriptional program present in the cell of origin. Using z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b19cc9b63340f3d9157007405afa4b
https://doi.org/10.1126/science.abc1048
https://doi.org/10.1126/science.abc1048
Autor:
Richard M. White, Emily Montal, Abderhman Abuhashem, Eleanor Johns, Joshua M. Weiss, Olayinka Ooladipupo, Dianne Lumaquin
Lipid droplets are lipid storage organelles found in nearly all cell types from adipocytes to cancer cells. Although increasingly implicated in disease, current methods to study lipid droplets require fixation or static imaging which limits investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::160b7c3330697fa735e0df776e3b13c2
https://doi.org/10.1101/2020.11.09.375667
https://doi.org/10.1101/2020.11.09.375667
Autor:
Richard M. White, Theresa Simon-Vermot, Tuan Trieu, Travis J. Hollmann, Emily Montal, Scott J. Callahan, Lorenz Studer, Barry S. Taylor, Satish K. Tickoo, Arianna Baggiolini, Richard Koche, Mohita Tagore, Nathalie Saurat, Ekta Khurana, Yujie Fan, Sam E. Tischfield, Joshua M. Weiss, Nathaniel R. Campbell
Oncogenes are only transforming in certain cellular contexts, a phenomenon called oncogenic competence. The mechanisms regulating this competence remain poorly understood. Here, using a combination of a novel human pluripotent stem cell (hPSC)-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e572918d7610d11233eaf62f54c50d
https://doi.org/10.1101/2020.05.09.081554
https://doi.org/10.1101/2020.05.09.081554