Patterning Biological Gels for 3D Cell Culture inside Microfluidic Devices by Local Surface Modification through Laminar Flow Patterning

Autor: Joshua Loessberg-Zahl, Jelle Beumer, Albert van den Berg, Jan C. T. Eijkel, Andries D. van der Meer

Publikováno v: Micromachines, Vol 11, Iss 12, p 1112 (2020)

Microfluidic devices are used extensively in the development of new in vitro cell culture models like organs-on-chips. A typical feature of such devices is the patterning of biological hydrogels to offer cultured cells and tissues a controlled three-

Externí odkaz: https://doaj.org/article/e0d3a296de50426fa046986bc9333e2b

Exploring Voltage Mediated Delamination of Suspended 2D Materials as a Cause of Commonly Observed Breakdown

Autor: Johan G. Bomer, Edwin Dollekamp, W.T.E. van den Beld, Boya Radha, Douwe S. de Bruijn, Jan C.T. Eijkel, Joshua Loessberg-Zahl, Eldad Grady, Ashok Keerthi, Ageeth A. Bol, Harold J.W. Zandvliet, A. van den Berg

Publikováno v: Journal of Physical Chemistry C, 124(1), 430-435. American Chemical Society
Loessberg-zahl, J, De Bruijn, D S, Van Den Beld, W T E, Dollekamp, E, Grady, E, Keerthi, A, Bomer, J G, Boya, R, Zandvliet, H J W, Bol, A A, Van Den Berg, A & Eijkel, J C T 2020, ' Exploring Voltage Mediated Delamination of Suspended 2D Materials as a Cause of Commonly Observed Breakdown ', The Journal of Physical Chemistry C, vol. 124, no. 1, pp. 430-435 . https://doi.org/10.1021/acs.jpcc.9b08500
Journal of physical chemistry C, 124(1), 430-435. American Chemical Society

Two-dimensional (2D) barrier materials such as graphene, boron nitride, and molybdenum disulfide hold great promise for important applications such as DNA sequencing, desalination, and biomolecular sensing. The 2D materials commonly span pores throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11d1338f6c52a6ea1101c2ad5643c36
https://doi.org/10.1021/acs.jpcc.9b08500

Microfluidic organ-on-a-chip model of the outer blood-retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure

Autor: Carlos Cuartas-Vélez, Sander Logtenberg, Albert van den Berg, Nienke Bosschaart, Joshua Loessberg-Zahl, Wesley Buijsman, Andries D. van der Meer, Anne M Grobbink, Robert Passier, Colin Veenstra, Yusuf B. Arik, Anneke I. den Hollander, Piet Bergveld, Giuliana Gagliardi

Publikováno v: Lab on a Chip, 21, 272-283
Lab on a chip, 21(2), 272-283. Royal Society of Chemistry
Lab on a chip, 2021(2). Royal Society of Chemistry
Lab on a Chip, 21, 2, pp. 272-283

The outer blood–retinal barrier (oBRB) tightly controls the transport processes between the neural tissue of the retina and the underlying blood vessel network. The barrier is formed by the retinal pigment epithelium (RPE), its basal membrane and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1586062a1e5bc4e15ae6ab1692951540
http://hdl.handle.net/2066/230610

Developing microfluidic tooling for 3D cell-culture

Autor: Joshua Loessberg-Zahl

This thesis admittedly covers a broad range of topics. While our exploration over the last four years has taken us far afield, from developing microfluidic multiplexers to uncovering breakdown modes of 2D material systems, this work was funded by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136ce2fa09a756fb60b9ab1cb1fbb626
https://research.utwente.nl/en/publications/developing-microfluidic-tooling-for-3d-cellculture(c23edbe1-b2ba-4014-af45-1334213601e7).html

Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips

Autor: Albert van den Berg, Jan C.T. Eijkel, Joshua Loessberg-Zahl, Andries D. van der Meer

Publikováno v: Lab on a chip, 19(2), 206-213. Royal Society of Chemistry
Lab on a Chip

Laminar flow patterning is an iconic microfluidic technology used to deliver chemicals to specific regions on a two-dimensional surface with high spatial fidelity. Here we present a novel extension of this technology using Darcy flow within a three-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7403f81aae01d06e8d9b05fce4e70ea7
https://research.utwente.nl/en/publications/758d444a-b27a-4dd0-a5d1-3cf85c414683