Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Joshua Levitz"'
Autor:
Alexa Strauss, Alberto J. Gonzalez-Hernandez, Joon Lee, Nohely Abreu, Purushotham Selvakumar, Leslie Salas-Estrada, Melanie Kristt, Anisul Arefin, Kevin Huynh, Dagan C. Marx, Kristen Gilliland, Bruce J. Melancon, Marta Filizola, Joel Meyerson, Joshua Levitz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The metabotropic glutamate receptors (mGluRs) are neuromodulatory family C G protein coupled receptors which assemble as dimers and allosterically couple extracellular ligand binding domains (LBDs) to transmembrane domains (TMDs) to drive in
Externí odkaz:
https://doaj.org/article/6e48d6960b5240c69e16e202a52f5256
Autor:
Cristina Lao-Peregrin, Guoqing Xiang, Jihye Kim, Ipsit Srivastava, Alexandra B. Fall, Danielle M. Gerhard, Piia Kohtala, Daegeon Kim, Minseok Song, Mikel Garcia-Marcos, Joshua Levitz, Francis S. Lee
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113595- (2024)
Summary: Cellular signaling involves a large repertoire of membrane receptors operating in overlapping spatiotemporal regimes and targeting many common intracellular effectors. However, both the molecular mechanisms and the physiological roles of cro
Externí odkaz:
https://doaj.org/article/28edfc249a87468a91385cfb259ade66
Autor:
Minfei Su, Jinan Wang, Guoqing Xiang, Hung Nguyen Do, Joshua Levitz, Yinglong Miao, Xin-Yun Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract α1-adrenergic receptors (α1-ARs) play critical roles in the cardiovascular and nervous systems where they regulate blood pressure, cognition, and metabolism. However, the lack of specific agonists for all α1 subtypes has limited our under
Externí odkaz:
https://doaj.org/article/63dfe8288c9a4a048a21d6655a5086b0
Autor:
George Khelashvili, Anoop Narayana Pillai, Joon Lee, Kalpana Pandey, Alexander M. Payne, Zarek Siegel, Michel A. Cuendet, Tylor R. Lewis, Vadim Y. Arshavsky, Johannes Broichhagen, Joshua Levitz, Anant K. Menon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Mutations in the G protein-coupled receptor (GPCR) rhodopsin are a common cause of autosomal dominant retinitis pigmentosa, a blinding disease. Rhodopsin self-associates in the membrane, and the purified monomeric apo-protein opsin dimerizes
Externí odkaz:
https://doaj.org/article/dd6f556860b34a2ea32087d0f5c5847f
Autor:
Chris H. Habrian, Joshua Levitz, Vojtech Vyklicky, Zhu Fu, Adam Hoagland, Isabelle McCort-Tranchepain, Francine Acher, Ehud Y. Isacoff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutama
Externí odkaz:
https://doaj.org/article/118cbbd567084baca674e6ab3894b693
Autor:
Jordana K Thibado, Jean-Yves Tano, Joon Lee, Leslie Salas-Estrada, Davide Provasi, Alexa Strauss, Joao Marcelo Lamim Ribeiro, Guoqing Xiang, Johannes Broichhagen, Marta Filizola, Martin J Lohse, Joshua Levitz
Publikováno v:
eLife, Vol 10 (2021)
The metabotropic glutamate receptors (mGluRs) form a family of neuromodulatory G-protein-coupled receptors that contain both a seven-helix transmembrane domain (TMD) and a large extracellular ligand-binding domain (LBD) which enables stable dimerizat
Externí odkaz:
https://doaj.org/article/6412386b702045d99bea060cfa1c8959
Autor:
Michael H. Berry, Amy Holt, Autoosa Salari, Julia Veit, Meike Visel, Joshua Levitz, Krisha Aghi, Benjamin M. Gaub, Benjamin Sivyer, John G. Flannery, Ehud Y. Isacoff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Activating the spared neurons downstream of rods and cones is a potential therapeutic approach for retinal degeneration, but has been limited by the characteristics of the opsins available. Here, the authors use medium wavelength cone opsin which has
Externí odkaz:
https://doaj.org/article/73e80c971db748c985115ccc7728f498
Autor:
Joon Lee, Hermany Munguba, Vanessa A. Gutzeit, Deo R. Singh, Melanie Kristt, Jeremy S. Dittman, Joshua Levitz
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107891- (2020)
Externí odkaz:
https://doaj.org/article/44ebe951577447279a851d8c0b39ba3d
Autor:
Michael H. Berry, Amy Holt, Joshua Levitz, Johannes Broichhagen, Benjamin M. Gaub, Meike Visel, Cherise Stanley, Krishan Aghi, Yang Joon Kim, Kevin Cao, Richard H. Kramer, Dirk Trauner, John Flannery, Ehud Y. Isacoff
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
To restore sight after retinal degeneration, one approach is to express light-sensitive proteins in remaining cells. Here the authors combine a light-sensitive engineered G protein-coupled receptor and ion channels to restore ON and OFF responses as
Externí odkaz:
https://doaj.org/article/633814130c744076adf5b920ac4c46b7
Autor:
Vanessa A Gutzeit, Jordana Thibado, Daniel Starer Stor, Zhou Zhou, Scott C Blanchard, Olaf S Andersen, Joshua Levitz
Publikováno v:
eLife, Vol 8 (2019)
Metabotropic glutamate receptors (mGluRs) are class C, synaptic G-protein-coupled receptors (GPCRs) that contain large extracellular ligand binding domains (LBDs) and form constitutive dimers. Despite the existence of a detailed picture of inter-LBD
Externí odkaz:
https://doaj.org/article/78177d0aa6b543d28b983fdb1e6cccb3