Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joshua Lehrer-Graiwer"'
Autor:
Maureen Achebe, Sarah Gray, Kenneth I. Ataga, Hoda Hassab, Amal El-Beshlawy, Elliott Vichinsky, Margaret Tonda, Videlis Nduba, Irene Agodoa, Jo Howard, Robert Clark Brown, Joshua Lehrer-Graiwer
Publikováno v:
The Lancet Haematology. 8:e323-e333
For decades, patients with sickle cell disease have had only a limited number of therapies available. In 2019, voxelotor (1500 mg), an oral once-daily sickle haemoglobin polymerisation inhibitor, was approved in the USA for the treatment of sickle ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9f65fcf8ec26745fd1e15dc57df93b
https://doi.org/10.1016/s2352-3026(21)00059-4
https://doi.org/10.1016/s2352-3026(21)00059-4
Autor:
Bart J. Biemond, Joshua Lehrer-Graiwer, Sarah Gray, Jennifer Knight-Madden, Caterina P. Minniti, Margaret Tonda
Publikováno v:
American Journal of Hematology
American journal of hematology, 96(4), E126-E128. Wiley-Liss Inc.
American journal of hematology, 96(4), E126-E128. Wiley-Liss Inc.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06990b47f01d8c491b31bc83ce8c3693
http://europepmc.org/articles/PMC7986764
http://europepmc.org/articles/PMC7986764
Autor:
Vishwanath R. Lingappa, Mittul Gulati, Sean D. McAllister, Evgenia Alpert, William Hansen, Joshua Lehrer-Graiwer, Arie Gruzman, Ming-Fong Lin, Eric B. Johansen, Armin Akhavan, Steven C. Hall
Publikováno v:
Bioscience Reports
The role of human prostatic acid phosphatase (PAcP, P15309|PPAP_HUMAN) in prostate cancer was investigated using a new proteomics tool termed signal sequence swapping (replacement of domains from the native cleaved amino terminal signal sequence of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93ed8fc5f7ccdbc0cbdb6971e61920d
https://pubmed.ncbi.nlm.nih.gov/34677582
https://pubmed.ncbi.nlm.nih.gov/34677582
Autor:
Vincent Siu, Timothy Mant, Mira Patel, Noel Landsman, Joshua Lehrer-Graiwer, Moji Awogbade, Kobina Dufu, John B. Porter, Daniel D. Gretler, Athiwat Hutchaleelaha, Sandra V. Dixon, Claire Hemmaway, Paul Telfer, D. Mark Layton, Jo Howard, Margaret Tonda
Publikováno v:
Blood. 133:1865-1875
New treatments directly targeting polymerization of sickle hemoglobin (HbS), the proximate event in the pathophysiology of sickle cell disease (SCD), are needed to address the severe morbidity and early mortality associated with the disease. Voxeloto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7890326c7b563b083e7615d4cfa0cca0
https://doi.org/10.1182/blood-2018-08-868893
https://doi.org/10.1182/blood-2018-08-868893
Autor:
David C. Shyr, Allison Intondi, Matthew H. Porteus, Daniel P. Dever, Alexandria Petrusich, John F. DiPersio, Joshua Lehrer-Graiwer, Patrick J. Leavey, Julie Kanter, Premanjali Lahiri, Alexis A. Thompson
Publikováno v:
Blood. 138:1864-1864
Background Sickle cell disease (SCD) is a recessive monogenic disease caused by a single point mutation in which glutamic acid replaces valine in Codon 6 of the human beta-globin gene (HBB) leading to the production of abnormal globin chains (HbS) th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::987e77ba3bdced03b267763b5cec43a8
https://doi.org/10.1182/blood-2021-152892
https://doi.org/10.1182/blood-2021-152892
Autor:
Elliott, Vichinsky, Carolyn C, Hoppe, Kenneth I, Ataga, Russell E, Ware, Videlis, Nduba, Amal, El-Beshlawy, Hoda, Hassab, Maureen M, Achebe, Salam, Alkindi, R Clark, Brown, David L, Diuguid, Paul, Telfer, Dimitris A, Tsitsikas, Ashraf, Elghandour, Victor R, Gordeuk, Julie, Kanter, Miguel R, Abboud, Joshua, Lehrer-Graiwer, Margaret, Tonda, Allison, Intondi, Barbara, Tong, Jo, Howard, Julie, Kanter Washko
Publikováno v:
The New England journal of medicine. 381(6)
Deoxygenated sickle hemoglobin (HbS) polymerization drives the pathophysiology of sickle cell disease. Therefore, direct inhibition of HbS polymerization has potential to favorably modify disease outcomes. Voxelotor is an HbS polymerization inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b73bdd279bf022b9774c5beb0fb85ce
https://pubmed.ncbi.nlm.nih.gov/31199089
https://pubmed.ncbi.nlm.nih.gov/31199089
Autor:
R. Clark Brown, Irene Agodoa, Videlis Nduba, Jo Howard, Hoda Hassab, Margaret Tonda, Kenneth I. Ataga, Maureen Achebe, Amal El-Beshlawy, Joshua Lehrer-Graiwer, Elliott Vichinsky, Sarah Gray
Publikováno v:
Blood. 136:19-19
Background: Sickle cell disease (SCD) is a lifelong, inherited disorder characterized by mutations in the hemoglobin (Hb) subunit β gene that leads to the production of sickle hemoglobin (HbS). When HbS is deoxygenated, polymerization leads to red b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::294c5b9264544e50ad5b377e8961de76
https://doi.org/10.1182/blood-2020-140553
https://doi.org/10.1182/blood-2020-140553
Publikováno v:
Contemporary Clinical Trials. 98:106161
Sickle cell disease (SCD) is an inherited disease characterized by hemolysis, anemia, and vaso-occlusion leading to substantial morbidity and mortality. Development of prior pharmacologic therapies exclusively utilized vaso-occlusive crisis (VOC) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a77f6fdf29c8e758af9e8858a371ab
https://doi.org/10.1016/j.cct.2020.106161
https://doi.org/10.1016/j.cct.2020.106161
Autor:
Margaret Tonda, Joshua Lehrer-Graiwer, Adlette Inati, Irene Agodoa, Kenneth I. Ataga, Elliott Vichinsky, Paul Telfer, Barbara Tong
Publikováno v:
Blood. 134:2313-2313
Background: Sickle cell disease (SCD) is an inherited disorder in which pathology is driven by hemoglobin (Hb) polymerization and red blood cell sickling, leading to chronic anemia and hemolysis as well as episodic vaso-occlusive crises (VOC). These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbe8a3fe91c155c0f47fee4016102dad
https://doi.org/10.1182/blood-2019-129026
https://doi.org/10.1182/blood-2019-129026
Autor:
Joshua Lehrer-Graiwer, Barbara Tong, Miguel R. Abboud, Russell E. Ware, Carolyn Hoppe, Clark Brown, Mariane de Montalembert, Margaret Tonda
Publikováno v:
Blood. 134:1003-1003
Background: Sickle cell disease (SCD) is a chronic, debilitating disorder caused by a mutation in beta globin, which leads to the production of sickle hemoglobin (HbS). Deoxygenated HbS polymerization results in red blood cell (RBC) sickling, which l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7389dca3542f6a5f7cb1482dae090048
https://doi.org/10.1182/blood-2019-130767
https://doi.org/10.1182/blood-2019-130767