Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Joshua L. Johnson"'
Vixotrigine is a voltage- and use-dependent sodium channel blocker under investigation for the potential treatment of neuropathic pain. One of the major in vivo metabolic pathways of vixotrigine in humans is the hydrolysis of the carboxamide to form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2525597e0f4f84ec1c1b003f86402a3
Autor:
Kristopher W King, Brenda Amaral, Eli Schuman, LaiYee Wong, Michael Rooney, Marta Nevalainen, Jun Feng, Paramasivam Murugan, Jayanth V. Chodaparambil, Thomas A. Patterson, Hannah Certo, Martin K Himmelbauer, Rab Gilfillan, Tamara Halkina, Sarah Lamore, J Howard Jones, Douglas Marcotte, Gregory M Dillon, Jaclyn L. Henderson, Thomas Hesson, P Rajesh Kumar, Edward Yin-Shiang Lin, Channa Bao, Felix Gonzalez-Lopez de Turiso, Joshua L Johnson, Michael Calhoun
Publikováno v:
Journal of medicinal chemistry. 64(9)
Structural analysis of the known NIK inhibitor 3 bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1 inhibitors exemplified by 8 (cell IC50: 571 nM). Systematic optimization of this series of anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24de7147f81434a735de9781d30290ec
https://pubmed.ncbi.nlm.nih.gov/33944571
https://pubmed.ncbi.nlm.nih.gov/33944571
Publikováno v:
PLoS Biology, Vol 6, Iss 7, p e170 (2008)
The nature of the "toxic gain of function" that results from amyotrophic lateral sclerosis (ALS)-, Parkinson-, and Alzheimer-related mutations is a matter of debate. As a result no adequate model of any neurodegenerative disease etiology exists. We d
Externí odkaz:
https://doaj.org/article/699205032ab541e9814c9d7449c576dc
Autor:
Thomas Hesson, Istvan J. Enyedy, Kristopher W King, Martin K Himmelbauer, Joseph C. Santoro, Paramasivam Murugan, J. Howard Jones, Joshua L Johnson, Felix Gonzalez-Lopez de Turiso, Kerri Spilker, Douglas Marcotte, Rab Gilfillan, Zhili Xin, Michael Joseph Luzzio
Publikováno v:
Journal of medicinal chemistry. 62(23)
Structural analysis of a known apoptosis signal-regulating kinase 1 (ASK1) inhibitor bound to its kinase domain led to the design and synthesis of the novel macrocyclic inhibitor 8 (cell IC50 = 1.2 μM). The profile of this compound was optimized for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150776d7925313644d75434a3c742926
https://pubmed.ncbi.nlm.nih.gov/31710475
https://pubmed.ncbi.nlm.nih.gov/31710475
Publikováno v:
Journal of the American Society for Mass Spectrometry. 28:278-285
A method is developed for the prediction of mass spectral ion counts of drug-like molecules using in silico calculated chemometric data. Various chemometric data, including polar and molecular surface areas, aqueous solvation free energies, and gas-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b3b1f0469a576e1fff82efd2ec6fe3
https://doi.org/10.1007/s13361-016-1536-4
https://doi.org/10.1007/s13361-016-1536-4
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::466810ecb7cbdebfd71a22375eae0f51
https://doi.org/10.1016/j.dmpk.2020.04.187
https://doi.org/10.1016/j.dmpk.2020.04.187
Publikováno v:
Journal of Chromatographic Science. 52:120-127
Selecting a suitable nano-liquid chromatography system (LC), ionization source and mass spectrometer for LC–tandem mass spectrometry (MS-MS) studies is complicated by numerous competing technologies. This study compares four popular nano-LC systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c5c9faeb27e12089693d33478a91d6
https://doi.org/10.1093/chromsci/bms255
https://doi.org/10.1093/chromsci/bms255
Autor:
Jeffrey N. Agar, Daryl A. Bosco, Joseph P. Salisbury, Sandro Santagata, Nathalie Y. R. Agar, Jared R. Auclair, Joshua L. Johnson, Gregory A. Petsko, Heather D. Durham, Dagmar Ringe
Publikováno v:
Proteomics. 14(10)
Bottom-up mass spectrometry studies typically employ a reduction and alkylation step that eliminates a class of post-translational modification, S-thiolation. Given that molecular oxygen can mediate S-thiolation from reduced thiols, which are abundan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc51913b7effdd9b96ad081daadc007
https://pubmed.ncbi.nlm.nih.gov/24634066
https://pubmed.ncbi.nlm.nih.gov/24634066
Autor:
Jared R. Auclair, Joseph P. Salisbury, Jeffrey N. Agar, Qian Liu, Dagmar Ringe, Melissa S. Rotunno, Joshua L. Johnson, Robert H. Brown, Gregory A. Petsko, Daryl A. Bosco
Publikováno v:
Biochemistry. 52(36)
Reactive oxygen species (ROS) are cytotoxic. To remove ROS, cells have developed ROS-specific defense mechanisms, including the enzyme Cu/Zn superoxide dismutase (SOD1), which catalyzes the disproportionation of superoxide anions into molecular oxyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807d88198c95298bfb0c4eb4cf4db308
https://pubmed.ncbi.nlm.nih.gov/23927036
https://pubmed.ncbi.nlm.nih.gov/23927036
Publikováno v:
2013 Kansas City, Missouri, July 21 - July 24, 2013.
North Carolina has grown to the third largest pork exporter in the United States mainly through the use of concentrated animal feed operations. Hog farming produces a large quantity of nutrient rich waste material that is generally disposed through l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b94f5215e4cea4149486754f38ffe68
https://doi.org/10.13031/aim.20131547529
https://doi.org/10.13031/aim.20131547529