Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells.

Autor: Imran S Khan, Chong Y Park, Anastasia Mavropoulos, Nikki Shariat, Joshua L Pollack, Andrea J Barczak, David J Erle, Michael T McManus, Mark S Anderson, Lukas T Jeker

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135440 (2015)

Thymic epithelial cells (TECs) support T cell development in the thymus. Cortical thymic epithelial cells (cTECs) facilitate positive selection of developing thymocytes whereas medullary thymic epithelial cells (mTECs) facilitate the deletion of self

Externí odkaz: https://doaj.org/article/bc33671b4766492aac0d1fbba09c6baf

Proboscidean mitogenomics: chronology and mode of elephant evolution using mastodon as outgroup.

Autor: Nadin Rohland, Anna-Sapfo Malaspinas, Joshua L Pollack, Montgomery Slatkin, Paul Matheus, Michael Hofreiter

Publikováno v: PLoS Biology, Vol 5, Iss 8, p e207 (2007)

We have sequenced the complete mitochondrial genome of the extinct American mastodon (Mammut americanum) from an Alaskan fossil that is between 50,000 and 130,000 y old, extending the age range of genomic analyses by almost a complete glacial cycle.

Externí odkaz: https://doaj.org/article/a31b1681ac9544f2921b18bcbc1c97d2

Data from Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

Autor: Matthew F. Krummel, Vincent Chan, Kevin C. Barry, Megan K. Ruhland, Sima P. Porten, Maxwell V. Meng, Rafael J. Argüello, Joshua L. Pollack, Alexandre Boissonnas, Jessica Tsui, Bushra Samad, Mikhail Binnewies, Arjun A. Rao, Alexis J. Combes, Adriana M. Mujal

The tumor immune microenvironment (TIME) is commonly infiltrated by diverse collections of myeloid cells. Yet, the complexity of myeloid-cell identity and plasticity has challenged efforts to define bona fide populations and determine their connectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8953b94f46fea8dcc25252890d730356
https://doi.org/10.1158/2326-6066.c.6550550.v1

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

Autor: Adriana M. Mujal, Alexis J. Combes, Arjun A. Rao, Mikhail Binnewies, Bushra Samad, Jessica Tsui, Alexandre Boissonnas, Joshua L. Pollack, Rafael J. Argüello, Maxwell V. Meng, Sima P. Porten, Megan K. Ruhland, Kevin C. Barry, Vincent Chan, Matthew F. Krummel

Publikováno v: Cancer immunology research, vol 10, iss 4
Cancer Immunol Res
Cancer Immunology Research
Cancer Immunology Research, 2022, 10 (4), pp.403-419. ⟨10.1158/2326-6066.CIR-21-0588⟩

The tumor immune microenvironment (TIME) is commonly infiltrated by diverse collections of myeloid cells. Yet, the complexity of myeloid-cell identity and plasticity has challenged efforts to define bona fide populations and determine their connectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6259c3082bdd43c5ab257597025ad0b
https://doi.org/10.1158/2326-6066.cir-21-0588

859 Tuning the tumor microenvironment by reprogramming TREM1+ myeloid cells to unleash anti-tumor immunity in solid tumors

Autor: Nadine Jahchan, Kevin P. Baker, Linda Liang, Hanna Ramoth, Shilpa Mankikar, Mikhail Binnewies, Vladislava Juric, Ranna Mehta, Joshua Rudolph, Joshua L. Pollack, Pamela Canaday, Subhadra Dash, Linnea Haeggblom, Leonard Reyno, Rachael Palmer, Erin Mayes, Carlos Santamaria, Xiaoyan Du

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundThe tumor microenvironment (TME) often contains high levels of suppressive myeloid cells that contribute to innate checkpoint inhibitor (CPI) resistance. Pionyr’s Myeloid Tuning approach involves altering the composition and/or the functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7996046e9e4f14903f5ce212e87c54b
https://doaj.org/article/aaddb178e1fb45d1bb53a4edaa2f5d6d