Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Joshua L Plotkin"'
Autor:
Lior Matityahu, Jeffrey M Malgady, Meital Schirelman, Yvonne Johansson, Jennifer A Wilking, Gilad Silberberg, Joshua A Goldberg, Joshua L Plotkin
Publikováno v:
eLife, Vol 11 (2022)
Striatal spiny projection neurons (SPNs) transform convergent excitatory corticostriatal inputs into an inhibitory signal that shapes basal ganglia output. This process is fine-tuned by striatal GABAergic interneurons (GINs), which receive overlappin
Externí odkaz:
https://doaj.org/article/519dd6a8cc334eaca05ae8e96999251d
Autor:
Luis Carrillo-Reid, Michelle Day, Zhong Xie, Alexandria E Melendez, Jyothisri Kondapalli, Joshua L Plotkin, David L Wokosin, Yu Chen, Geraldine J Kress, Michael Kaplitt, Ema Ilijic, Jaime N Guzman, C Savio Chan, D James Surmeier
Publikováno v:
eLife, Vol 8 (2019)
Huntington’s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mech
Externí odkaz:
https://doaj.org/article/6d433a31aa0f4103a04bf72732b8b59c
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/c61f12a6aa54419aa57bb689f2bb6140
Autor:
Jeffrey M. Malgady, Alexander Baez, Zachary B. Hobel, Kimberly Jimenez, Jack Goldfried, Eric M. Prager, Jennifer A. Wilking, Qiangge Zhang, Guoping Feng, Joshua L. Plotkin
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113384- (2023)
Summary: Deletion of the obsessive-compulsive disorder (OCD)-associated gene SAP90/PSD-95-associated protein 3 (Sapap3), which encodes a postsynaptic anchoring protein at corticostriatal synapses, causes OCD-like motor behaviors in mice. While cortic
Externí odkaz:
https://doaj.org/article/b0b11650ae514587bd0d6ac0e3f98936
Autor:
Allen P. F. Chen, Jeffrey M. Malgady, Lu Chen, Kaiyo W. Shi, Eileen Cheng, Joshua L. Plotkin, Shaoyu Ge, Qiaojie Xiong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The auditory striatum, the tail portion of dorsal striatum, is implicated in decision-making. This study uncovers a phasic mechanism within the nigrostriatal system that regulates auditory decisions by modulating ongoing auditory perception.
Externí odkaz:
https://doaj.org/article/4a06605773c347e08470742fd6f0dda1
Autor:
Yvonne Johansson, Meital Schirelman, Joshua L. Plotkin, Gilad Silberberg, Lior Matityahu, Joshua A. Goldberg, Jeffrey M. Malgady, Jennifer Wilking
Publikováno v:
eLife. 11
Striatal spiny projection neurons (SPNs) transform convergent excitatory corticostriatal inputs into an inhibitory signal that shapes basal ganglia output. This process is fine-tuned by striatal GABAergic interneurons (GINs), which receive overlappin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f32917435518257d1059de7e1b5786
https://doi.org/10.7554/elife.75829
https://doi.org/10.7554/elife.75829
Autor:
Meital Schirelman, Jeffrey M Malgady, Lior Matityahu, Yvonne Johansson, Jennifer A Wilking, Gilad Silberberg, Joshua A Goldberg, Joshua L Plotkin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c7d61fe92ea2025b8648c632be23632
https://doi.org/10.7554/elife.75829.sa2
https://doi.org/10.7554/elife.75829.sa2
Autor:
Jeffrey M. Malgady, Alexander Baez, Kimberly Jimenez, Zachary B. Hobel, Eric M. Prager, Qiangge Zhang, Guoping Feng, Joshua L. Plotkin
SummaryDeletion of the OCD-associated gene SAP90/PSD-95-associated protein 3 (Sapap3), which encodes a postsynaptic anchoring protein at corticostriatal synapses, causes OCD-like motor behaviors in mice. While corticostriatal synaptic dysfunction is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02d940494c16f9deca4254c6ca49c8c
https://doi.org/10.1101/2022.02.07.479446
https://doi.org/10.1101/2022.02.07.479446
Publikováno v:
bioRxiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::09f32917435518257d1059de7e1b5786
Autor:
Zachary B. Hobel, Daniel B. Dorman, Eric M. Prager, Kim T. Blackwell, Joshua L. Plotkin, Jeffrey M. Malgady
Publikováno v:
Neuron
Corticostriatal synaptic integration is partitioned among striosome (patch) and matrix compartments of the dorsal striatum, allowing compartmentalized control of discrete aspects of behavior. Despite the significance of such organization, it's unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bfbe3cb72ffaad1fa3a5d58cca44a7
https://europepmc.org/articles/PMC7769890/
https://europepmc.org/articles/PMC7769890/