Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Joshua L Dunaief"'
Autor:
Federica Storti, Katrin Klee, Vyara Todorova, Regula Steiner, Alaa Othman, Saskia van der Velde-Visser, Marijana Samardzija, Isabelle Meneau, Maya Barben, Duygu Karademir, Valda Pauzuolyte, Sanford L Boye, Frank Blaser, Christoph Ullmer, Joshua L Dunaief, Thorsten Hornemann, Lucia Rohrer, Anneke den Hollander, Arnold von Eckardstein, Jürgen Fingerle, Cyrille Maugeais, Christian Grimm
Publikováno v:
eLife, Vol 8 (2019)
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transpor
Externí odkaz:
https://doaj.org/article/992b60ec1c9e471eb4c01c575ad91eb9
Autor:
Delu Song, Brooks Wilson, Liangliang Zhao, Rupak Bhuyan, Mausumi Bandyopadhyay, Arkady Lyubarsky, Chen Yu, Yafeng Li, Levi Kanu, Takashi Miwa, Wen-Chao Song, Silvia C Finnemann, Bärbel Rohrer, Joshua L Dunaief
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166348 (2016)
Complement dysregulation plays a key role in the pathogenesis of age-related macular degeneration (AMD), but the specific mechanisms are incompletely understood. Complement also potentiates retinal degeneration in the murine light damage model. To te
Externí odkaz:
https://doaj.org/article/8ce85ffb9f814883bd1cf53766c779c5
Autor:
Brie K Fuqua, Yan Lu, Deepak Darshan, David M Frazer, Sarah J Wilkins, Natalie Wolkow, Austin G Bell, JoAnn Hsu, Catherine C Yu, Huijun Chen, Joshua L Dunaief, Gregory J Anderson, Chris D Vulpe
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98792 (2014)
Hephaestin is a vertebrate multicopper ferroxidase important for the transfer of dietary iron from intestinal cells to the blood. Hephaestin is mutated in the sex-linked anemia mouse, resulting in iron deficiency. However, sex-linked anemia mice stil
Externí odkaz:
https://doaj.org/article/9456e0ed760148cfb4de02d0a7893399
Autor:
Kevin R. Zhang, Connor S. R. Jankowski, Rayna Marshall, Rohini Nair, Néstor Más Gómez, Ahab Alnemri, Yingrui Liu, Elizabeth Erler, Julia Ferrante, Ying Song, Brent A. Bell, Bailey H. Baumann, Jacob Sterling, Brandon Anderson, Sierra Foshe, Jennifer Roof, Hossein Fazelinia, Lynn A. Spruce, Jen-Zen Chuang, Ching-Hwa Sung, Anuradha Dhingra, Kathleen Boesze-Battaglia, Venkata R. M. Chavali, Joshua D. Rabinowitz, Claire H. Mitchell, Joshua L. Dunaief
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 7 (2023)
Externí odkaz:
https://doaj.org/article/bef89837dcc1421d99a9a8707134f0ad
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 7 (2023)
Externí odkaz:
https://doaj.org/article/bc30e42e92104d1da83920b8047dd9a7
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
IntroductionOphthalmic imaging instruments, including the confocal scanning laser ophthalmoscope and spectral-domain optical coherence tomography system, originally intended for revealing ocular microstructures in the human eye, have been deployed by
Externí odkaz:
https://doaj.org/article/d033e02506274c368de44baa5968af93
Autor:
Jen-Zen Chuang, Nan Yang, Nobuyuki Nakajima, Wataru Otsu, Cheng Fu, Howard Hua Yang, Maxwell Ping Lee, Armaan Fazal Akbar, Tudor Constantin Badea, Ziqi Guo, Afnan Nuruzzaman, Kuo-Shun Hsu, Joshua L. Dunaief, Ching-Hwa Sung
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Age-related macular degeneration (AMD) is a leading cause of blindness and is characterised by the accumulation of lipid deposits, called drusen. Here, the authors show that mice lacking chloride intracellular channel 4 in retinal pigment epithelium
Externí odkaz:
https://doaj.org/article/6225ad8d8100460da61f269eb1c4addd
Autor:
Benjamin J. Kim, Vivian Lee, Edward B. Lee, Adrienne Saludades, John Q. Trojanowski, Joshua L. Dunaief, Murray Grossman, David J. Irwin
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-8 (2021)
Abstract Alzheimer’s disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning. In contrast, we have seen outer retina thinning driven by photoreceptor outer nuclear layer (ONL) thinning with antemortem optical co
Externí odkaz:
https://doaj.org/article/9b9e6585afe94301bd7742334141f114
Autor:
Shuo Huang, Chi-Hsiu Liu, Zhongxiao Wang, Zhongjie Fu, William R. Britton, Alexandra K. Blomfield, Theodore M. Kamenecka, Joshua L. Dunaief, Laura A. Solt, Jing Chen
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102261- (2022)
Retinal pigment epithelium (RPE) dysfunction and atrophy occur in dry age-related macular degeneration (AMD), often leading to photoreceptor degeneration and vision loss. Accumulated oxidative stress during aging contributes to RPE dysfunction and de
Externí odkaz:
https://doaj.org/article/d3c8835aceba4b349400a9c669a90905
Publikováno v:
BMJ case reports. 14(12)
We report a case of a 60-year-old man who struggled with frequent migraines for 12.5 years, which were refractory to all conventional therapies. Six months before initial consultation, these migraines become chronic. The patient was then advised to f