Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Joshua L, Smalley"'
Autor:
Noell Cho, Georgina Kontou, Joshua L. Smalley, Christopher Bope, Jacob Dengler, Kristopher Montrose, Tarek Z. Deeb, Nicholas J. Brandon, Tadashi Yamamoto, Paul A. Davies, Georgios Giamas, Stephen J. Moss
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109512- (2024)
Summary: LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy, its physiological significance is u
Externí odkaz:
https://doaj.org/article/fe648812ed2245d28cd51d531ae0f3c3
Autor:
Joshua L. Smalley, Noell Cho, Shu Fun Josephine Ng, Catherine Choi, Abigail H. S. Lemons, Saad Chaudry, Christopher E. Bope, Jake S. Dengler, Chuansheng Zhang, Matthew N. Rasband, Paul A. Davies, Stephen J. Moss
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
The subunit composition of GABAA receptors and their interaction with beta spectrin complexes influences their localization between the neuronal axon initial segment or dendrites.
Externí odkaz:
https://doaj.org/article/edfc1bb22db642f7ab73e66911075353
Autor:
Catherine Choi, Joshua L. Smalley, Abigail H. S. Lemons, Qiu Ren, Christopher E. Bope, Jake S. Dengler, Paul A. Davies, Stephen J. Moss
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Impaired inhibitory signaling underlies the pathophysiology of many neuropsychiatric and neurodevelopmental disorders including autism spectrum disorders and epilepsy. Neuronal inhibition is regulated by synaptic and extrasynaptic γ-aminobutyric aci
Externí odkaz:
https://doaj.org/article/b30ccc0be6cc46cfb9340dd34a6deb46
Autor:
Joshua L. Smalley, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Stephen J. Moss
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purifi
Externí odkaz:
https://doaj.org/article/baaab0297501451c838881430fb7712c
Autor:
Matt R. Kelley, Ross A. Cardarelli, Joshua L. Smalley, Thomas A. Ollerhead, Peter M. Andrew, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss
Publikováno v:
EBioMedicine, Vol 32, Iss , Pp 62-71 (2018)
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic i
Externí odkaz:
https://doaj.org/article/48778aaa8f3145169b545ba38e5c06bc
Autor:
Anna J. Nathanson, Yihui Zhang, Joshua L. Smalley, Thomas A. Ollerhead, Miguel A. Rodriguez Santos, Peter M. Andrews, Heike J. Wobst, Yvonne E. Moore, Nicholas J. Brandon, Rochelle M. Hines, Paul A. Davies, Stephen J. Moss
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 670-681.e8 (2019)
Summary: The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites. Synaptic GABAARs are constructed from α(1-3), β(1-3), and γ2 subunits, and
Externí odkaz:
https://doaj.org/article/21aef49f490e40c29d479eb0c499b258
Autor:
Aaron Goldman, Shiladitya Sengupta, Mohammad Kohandel, Kazuya Arai, Mamunur Rahman, Allen Thayakumar, Andrew Brown, Joshua L. Smalley, Elliot O. Eton, Nithya Ramadurai, Sachin Khiste, Tanmoy Saha, Chinmayee Dash, Moriah Pellowe, Basavaraja Shanthappa, David Goldman, Douglas Best, Jayanta Mondal, Siva Kumar Natarajan, Munisha Smalley
Supplemental figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a69a98834ed945eb350abe0de8bad67
https://doi.org/10.1158/0008-5472.22426966.v1
https://doi.org/10.1158/0008-5472.22426966.v1
Autor:
Aaron Goldman, Shiladitya Sengupta, Mohammad Kohandel, Kazuya Arai, Mamunur Rahman, Allen Thayakumar, Andrew Brown, Joshua L. Smalley, Elliot O. Eton, Nithya Ramadurai, Sachin Khiste, Tanmoy Saha, Chinmayee Dash, Moriah Pellowe, Basavaraja Shanthappa, David Goldman, Douglas Best, Jayanta Mondal, Siva Kumar Natarajan, Munisha Smalley
supplemental tables 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d5c3520e11cd3e02d349910a45a30f
https://doi.org/10.1158/0008-5472.22426960
https://doi.org/10.1158/0008-5472.22426960
Autor:
Aaron Goldman, Shiladitya Sengupta, Mohammad Kohandel, Kazuya Arai, Mamunur Rahman, Allen Thayakumar, Andrew Brown, Joshua L. Smalley, Elliot O. Eton, Nithya Ramadurai, Sachin Khiste, Tanmoy Saha, Chinmayee Dash, Moriah Pellowe, Basavaraja Shanthappa, David Goldman, Douglas Best, Jayanta Mondal, Siva Kumar Natarajan, Munisha Smalley
Drug-induced resistance, or tolerance, is an emerging yet poorly understood failure of anticancer therapy. The interplay between drug-tolerant cancer cells and innate immunity within the tumor, the consequence on tumor growth, and therapeutic strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f17ead42ce304f5bda21f8341a0b90a4
https://doi.org/10.1158/0008-5472.c.6512503.v1
https://doi.org/10.1158/0008-5472.c.6512503.v1
Autor:
Aaron Goldman, Shiladitya Sengupta, Mohammad Kohandel, Kazuya Arai, Mamunur Rahman, Allen Thayakumar, Andrew Brown, Joshua L. Smalley, Elliot O. Eton, Nithya Ramadurai, Sachin Khiste, Tanmoy Saha, Chinmayee Dash, Moriah Pellowe, Basavaraja Shanthappa, David Goldman, Douglas Best, Jayanta Mondal, Siva Kumar Natarajan, Munisha Smalley
detailed methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7817c10c5fda1b4b06c29c8f1ff0f1
https://doi.org/10.1158/0008-5472.22426963.v1
https://doi.org/10.1158/0008-5472.22426963.v1