PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory

Autor: Chae-Seok Lim, Hye Jin Nam, Jaehyun Lee, Dongha Kim, Ja Eun Choi, SukJae Joshua Kang, Somi Kim, Hyopil Kim, Chuljung Kwak, Kyu-Won Shim, Siyong Kim, Hyoung-Gon Ko, Ro Un Lee, Eun-Hae Jang, Juyoun Yoo, Jaehoon Shim, Md Ariful Islam, Yong-Seok Lee, Jae-Hyung Lee, Sung Hee Baek, Bong-Kiun Kaang

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory. Although LSD1 phosphorylation by PKCα was imp

Externí odkaz: https://doaj.org/article/0d31f3b5d7f647abb2626298419871e9

Pilot Study: Utilization of Telemedicine and Enhanced Recovery after Surgery in Adolescent Metabolic and Bariatric Surgery

Autor: Hae Sung Kang, Cody McHargue, Samuel Kraus, Joshua Kang, Dima Malkawi, Vinh Dao, Nancy Thompson, Jonathan DeAntonio, Claudio Oiticica, David A. Lanning

Introduction: Principles of Enhanced Recovery after Surgery (ERAS) have been successful in improving adult perioperative care. We have previously shown the feasibility of telemedicine in pediatric postoperative care. This study assesses the effective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::587532d21cec524891a8deb2d3885319
https://doi.org/10.21203/rs.3.rs-1498345/v1

Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury

Autor: Christoph W. Turck, Somi Kim, Hyun Jeong Kim, Ji-il Kim, Jaehoon Shim, Sanghyun Ye, Hyoung-Gon Ko, Siyong Kim, Jeehaeh Do, Ariful Islam, Sukjae Joshua Kang, Jihye Park, Su-Eon Sim, Chae-Seok Lim, Min Zhuo, Jaehyun Lee, Dong Ik Park, Graham L. Collingridge, Jun-Hyeok Choi, Pojeong Park, Tae-Hyeok Choi, Bong-Kiun Kaang

Publikováno v: Ko, H-G, Choi, J-H, Park, D I, Kang, S J, Lim, C-S, Sim, S-E, Shim, J, Kim, J-I, Kim, S, Choi, T-H, Ye, S, Lee, J, Park, P, Kim, S, Do, J, Park, J, Islam, M A, Kim, H J, Turck, C W, Collingridge, G L, Zhuo, M & Kaang, B-K 2018, ' Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury ', Cell Reports, vol. 22, no. 3, pp. 748-759 . https://doi.org/10.1016/j.celrep.2017.12.059
CELL REPORTS
Cell Reports, Vol 22, Iss 3, Pp 748-759 (2018)

Peripheral nerve injury can induce pathological conditions that lead to persistent sensitized nociception. Although there is evidence that plastic changes in the cortex contribute to this process, the underlying molecular mechanisms are unclear. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90aabfc247c81b82b41461b66055c985
https://doi.org/10.1016/j.celrep.2017.12.059

Metabotropic glutamate receptor dependent long-term depression in the cortex.

Autor: Sukjae Joshua Kang¹, Bong-Kiun Kaang^2,3

Publikováno v: Korean Journal of Physiology & Pharmacology. Nov2016, Vol. 20 Issue 6, p557-564. 8p.

Defective Synapse Maturation and Enhanced Synaptic Plasticity in Shank2 Δex7-/- Mice

Autor: Arne Buschler, Sarah A. Shoichet, Chae-Seok Lim, Stephanie Wegener, Denise Manahan-Vaughan, Bong-Kiun Kaang, Sukjae Joshua Kang, A. Vanessa Stempel, Dietmar Schmitz

Publikováno v: eNeuro 5(3), ENEURO.0398-17.2018 (2018). doi:10.1523/ENEURO.0398-17.2018
eNeuro

Visual Abstract
Autism spectrum disorders (ASDs) are neurodevelopmental disorders with a strong genetic etiology. Since mutations in human SHANK genes have been found in patients with autism, genetic mouse models are used for a mechanistic under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2100f9d2faa3afd1ae792b20a199b1
https://pub.dzne.de/record/141133