Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joshua K. Thackray"'
Autor:
Berta N. Vazquez, Irene Fernández-Duran, Yurdiana Hernandez, Shahriar Tarighi, Joshua K. Thackray, Maria Espinosa-Alcantud, Poonam Kumari, Alessandro Ianni, Lionel Cesaire, Thomas Braun, Manel Esteller, Jay Tischfield, Alejandro Vaquero, Lourdes Serrano
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
p53 is a hallmark tumor suppressor due in part to its role in cell cycle progression, DNA damage repair, and cellular apoptosis; its protein activity interrelates with the Sirtuin family of proteins, major regulators of the cellular response to metab
Externí odkaz:
https://doaj.org/article/1c3e85eb7aee42cd830d2e05171e732e
Autor:
Kevin Tong, Oscar Pellón-Cárdenas, Veerin R. Sirihorachai, Bailey N. Warder, Om A. Kothari, Ansu O. Perekatt, Emily E. Fokas, Robert L. Fullem, Anbo Zhou, Joshua K. Thackray, Hiep Tran, Lanjing Zhang, Jinchuan Xing, Michael P. Verzi
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3833-3845 (2017)
Oncogenic mutations in BRAF are believed to initiate serrated colorectal cancers; however, the mechanisms of BRAF-driven colon cancer are unclear. We find that oncogenic BRAF paradoxically suppresses stem cell renewal and instead promotes differentia
Externí odkaz:
https://doaj.org/article/012715f62d1c4a9eb89f470d4fb955d6
Autor:
Laia Bosch-Presegué, Helena Raurell-Vila, Joshua K. Thackray, Jessica González, Carmen Casal, Noriko Kane-Goldsmith, Miguel Vizoso, Jeremy P. Brown, Antonio Gómez, Juan Ausió, Timo Zimmermann, Manel Esteller, Gunnar Schotta, Prim B. Singh, Lourdes Serrano, Alejandro Vaquero
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2048-2057 (2017)
HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1α−/−, Hp1β−/−, and Hp1
Externí odkaz:
https://doaj.org/article/b92ca1c79844433cb1579b663e305b5b
Autor:
Lauren A. Poppi, K.T. Ho-Nguyen, Junbing Wu, Matthew Matrongolo, Joshua K. Thackray, Cara Nasello, Anna Shi, Matthew Ricci, Nicolas L. Carayannopoulos, Nithisha Cheedalla, Julianne McGinnis, Samantha Schaper, Cynthia Daut, Jurdiana Hernandez, Gary A. Heiman, Jay A. Tischfield, Max A. Tischfield
CELSR3 encodes an atypical protocadherin cell adhesion receptor that was recently identified as a high-risk gene for Tourette disorder. A putative damaging de novo variant was inserted into the mouse genome to generate an amino acid substitution with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc51b5470da5434bbebb32e68c4ba87
https://doi.org/10.1101/2022.03.06.483205
https://doi.org/10.1101/2022.03.06.483205
Autor:
Manon Bohic, Jhumka Za, Matthew Ricci, Luke A. Pattison, Mossazghi N, Arnold J, Max A. Tischfield, Rossi H, William H. Foster, Joshua K. Thackray, Eric A. Yttri, Smith Esj, Abdus-Saboor I, Victoria E. Abraira
Inflammatory pain represents a complex state involving sensitization of peripheral and central neuronal signaling. Resolving this high-dimensional interplay at the cellular and behavioral level is key to effective therapeutic development. Here, using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af17cffee106d09231624390ad4c9c90
https://doi.org/10.1101/2021.06.16.448689
https://doi.org/10.1101/2021.06.16.448689
Autor:
Gary A. Heiman, Samuel Kuperman, Andrea Dietrich, Li Deng, Julie Hagstrøm, Yeting Zhang, Jinchuan Xing, Xiaolong Cao, Lisheng Zhou, Pieter J. Hoekstra, Cara Nasello, Astrid Morer, Jay A. Tischfield, Mohamed Abdulkadir, Blanca Garcia-Delgar, Joshua K. Thackray, Kerstin J. Plessen, Justin Koesterich, Thomas V. Fernandez, Robert A. King
Publikováno v:
Molecular psychiatry
Molecular Psychiatry. Nature Publishing Group
Molecular psychiatry, vol. 26, no. 11, pp. 6937-6951
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular psychiatry. Nature Publishing Group
Molecular Psychiatry. Nature Publishing Group
Molecular psychiatry, vol. 26, no. 11, pp. 6937-6951
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular psychiatry. Nature Publishing Group
Tourette’s Disorder (TD) is a neurodevelopmental disorder (NDD) that affects about 0.7% of the population and is one of the most heritable NDDs. Nevertheless, because of its polygenic nature and genetic heterogeneity, the genetic etiology of TD is
Autor:
Sheng Wang, Jeffrey D. Mandell, Yogesh Kumar, Nawei Sun, Montana T. Morris, Juan Arbelaez, Cara Nasello, Shan Dong, Clif Duhn, Xin Zhao, Zhiyu Yang, Shanmukha S. Padmanabhuni, Dongmei Yu, Robert A. King, Andrea Dietrich, Najah Khalifa, Niklas Dahl, Alden Y. Huang, Benjamin M. Neale, Giovanni Coppola, Carol A. Mathews, Jeremiah M. Scharf, Thomas V. Fernandez, Joseph D. Buxbaum, Silvia De Rubeis, Dorothy E. Grice, Jinchuan Xing, Gary A. Heiman, Jay A. Tischfield, Peristera Paschou, A. Jeremy Willsey, Matthew W. State, Mohamed Abdulkadir, Benjamin Bodmer, Yana Bromberg, Lawrence W. Brown, Keun-Ah Cheon, Barbara J. Coffey, Li Deng, Lonneke Elzerman, Carolin Fremer, Blanca Garcia-Delgar, Donald L. Gilbert, Julie Hagstrøm, Tammy Hedderly, Isobel Heyman, Pieter J. Hoekstra, Hyun Ju Hong, Chaim Huyser, Eun-Joo Kim, Young Key Kim, Young-Shin Kim, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Bennett L Leventhal, Andrea G. Ludolph, Marcos Madruga-Garrido, Athanasios Maras, Pablo Mir, Astrid Morer, Montana T Morris, Kirsten Müller-Vahl, Alexander Münchau, Tara L. Murphy, Kerstin J. Plessen, Hannah Poisner, Veit Roessner, Stephan J. Sanders, Eun-Young Shin, Dong-Ho Song, Jungeun Song, Joshua K. Thackray, Jennifer Tübing, Frank Visscher, Sina Wanderer, A Jeremy Willsey, Martin Woods, Yeting Zhang, Samuel H. Zinner, Christos Androutsos, Csaba Barta, Luca Farkas, Jakub Fichna, Marianthi Georgitsi, Piotr Janik, Iordanis Karagiannidis, Anastasia Koumoula, Peter Nagy, Joanna Puchala, Renata Rizzo, Natalia Szejko, Urszula Szymanska, Zsanett Tarnok, Vaia Tsironi, Tomasz Wolanczyk, Cezary Zekanowski, Cathy L. Barr, James R. Batterson, Cheston Berlin, Ruth D. Bruun, Cathy L. Budman, Danielle C. Cath, Sylvain Chouinard, Nancy J. Cox, Sabrina Darrow, Lea K. Davis, Yves Dion, Nelson B. Freimer, Marco A. Grados, Matthew E. Hirschtritt, Cornelia Illmann, Roger Kurlan, James F. Leckman, Gholson J. Lyon, Irene A. Malaty, William M. MacMahon, Michael S. Okun, Lisa Osiecki, David L. Pauls, Danielle Posthuma, Vasily Ramensky, Mary M. Robertson, Guy A. Rouleau, Paul Sandor, Harvey S. Singer, Jan Smit, Jae-Hoon Sul
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3441-3454.e12 (2018)
Cell reports, vol. 24, no. 13, pp. 3441-3454.e12
Cell reports
Cell reports, 24(13), 3441-3454.e12. CELL PRESS
Cell reports, vol. 24, no. 13, pp. 3441-3454.e12
Cell reports
Cell reports, 24(13), 3441-3454.e12. CELL PRESS
SUMMARY We previously established the contribution of de novo damaging sequence variants to Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence an additional 291 TD trios and analyze the combined set of 802 trios. We
Autor:
Alejandro Vaquero, Carmen Casal, Manel Esteller, Miguel Vizoso, Jeremy P. Brown, Laia Bosch-Presegué, Gunnar Schotta, Lourdes Serrano, Helena Raurell-Vila, Noriko Kane-Goldsmith, Antonio Gomez, Joshua K. Thackray, Timo Zimmermann, Jessica González, Juan Ausió, Prim B. Singh
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2048-2057 (2017)
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1α-/-, Hp1β-/-, and Hp1γ-/- ME
Autor:
Carolina De La Torre, Eduard Sabidó, Jay A. Tischfield, Lourdes Serrano, Nicolas G. Simonet, Marcus Buschbeck, Julia Morales-Sanfrutos, Maria Espinosa-Alcantud, Manel Esteller, Mireia Olivella, Joshua K. Thackray, Thomas Braun, Alejandro Vaquero, Berta N. Vazquez, Sarah Hurtado-Bagès, Alessandro Ianni
Sirtuins are key players in the response to oxidative, metabolic and genotoxic stress, and are involved in genome stability, metabolic homeostasis and aging. Originally described as NAD+-dependent deacetylases, some sirtuins are also characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ebfcae38fa761ead84d43a2ece8c1b
Autor:
Simon J. Newkirk, Lourdes Serrano, Jay A. Tischfield, Nicolas G. Simonet, Joshua K. Thackray, Berta N. Vazquez, Wenfeng An, Alejandro Vaquero, Suman Lee, Noriko Kane-Goldsmith, Sanjay Chahar, Michael P. Verzi, Jinchuan Xing
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Dipòsit Digital de la UB
Universidad de Barcelona
Nucleic Acids Research
Universitat Autònoma de Barcelona
Dipòsit Digital de la UB
Universidad de Barcelona
Nucleic Acids Research
Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how this process becomes dysfunctional during aging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d967404c2a77e8b4d1ef528fe42bcd74
http://hdl.handle.net/2445/171238
http://hdl.handle.net/2445/171238