Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Joshua J. Martindale"'
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78768 (2013)
Tamoxifen (Tam), a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer. High Tam doses have been used for treatment of gliomas and cancers with multiple drug resistance, but long QT Syndrom
Externí odkaz:
https://doaj.org/article/3fcb916d4fe94cc9bb7e90326fe8a03e
Publikováno v:
Scientific Reports
Molecular inotropy refers to cardiac contractility that can be modified to affect overall heart pump performance. Here we show evidence of a new molecular pathway for positive inotropy by a cardiac-restricted microRNA (miR). We report enhanced cardia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a204b260f3d6bead156c4595ed6ed3d
https://doi.org/10.1038/srep36803
https://doi.org/10.1038/srep36803
Autor:
Wenqiong J. Chen, Donna J. Thuerauf, Joshua J. Martindale, Marie Marcinko, Natalie Gude, Archana Tadimalla, Peter J. Belmont, Mark A. Sussman, Christopher C. Glembotski
Publikováno v:
Journal of Biological Chemistry. 283:14012-14021
Exposing cells to conditions that modulate growth can impair endoplasmic reticulum (ER) protein folding, leading to ER stress and activation of the transcription factor, ATF6. ATF6 binds to ER stress response elements in target genes, inducing expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00e4dc48fb93918bdbb6e7c34f20322
https://doi.org/10.1074/jbc.m709776200
https://doi.org/10.1074/jbc.m709776200
Autor:
Weitao Wu, Steven R. Houser, Sailay Siddiqi, Erik Schaefer, Gregory Emmanuel, Francesca Delucchi, Christopher C. Glembotski, Jenna Fransioli, Piero Anversa, Yu Misao, Mark A. Sussman, Joshua J. Martindale, Annarosa Leri, Kimberlee M. Fischer, Roberto Alvarez, Jan Kajstura, Remus M Beretta, Michael L. Arcarese, John A. Muraski, Grazia Esposito, Natalie Gude, Nancy S. Magnuson, Christopher T. Cottage, Anton Berns, Marcello Rota
Publikováno v:
Nature Medicine. 13:1467-1475
The serine-threonine kinases Pim-1 and Akt regulate cellular proliferation and survival. Although Akt is known to be a crucial signaling protein in the myocardium, the role of Pim-1 has been overlooked. Pim-1 expression in the myocardium of mice decr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb35b9ae0d8cd555e6fe0f3cef3083d
https://doi.org/10.1038/nm1671
https://doi.org/10.1038/nm1671
Autor:
Jing Wei, Roberta A. Gottlieb, M. R. Sayen, Wenqiong J. Chen, Joshua J. Martindale, Jason A. Wall, Peter J. Belmont, Wen Yu, Jun Sun, Åsa B. Gustafsson, Christopher C. Glembotski, Paul Oeller, Mimi Ly, Diem Tran, Steve Briggs
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 291:H2462-H2472
Ischemia-reperfusion (I/R) has critical consequences in the heart. Recent studies on the functions of I/R-activated kinases, such as p38 mitogen-activated protein kinase (MAPK), showed that I/R injury is reduced in the hearts of transgenic mice that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fdf0c5cc35aed32f0af703c1395da3
https://doi.org/10.1152/ajpheart.01311.2005
https://doi.org/10.1152/ajpheart.01311.2005
Publikováno v:
Journal of Biological Chemistry. 275:23825-23833
The MAPK kinase MKK6 selectively stimulates p38 MAPK and confers protection against stress-induced apoptosis in cardiac myocytes. However, the events lying downstream of p38 that mediate this protection are unknown. The small heat shock protein, alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3163f535ec88f7b79896137afb6fab18
https://doi.org/10.1074/jbc.m003864200
https://doi.org/10.1074/jbc.m003864200
Myocardial ischemia/reperfusion (I/R) injury is a major clinical problem leading to cardiac dysfunction and myocyte death. It is widely held that I/R causes damage to membrane phospholipids, and is a significant mechanism of cardiac I/R injury. Molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a493a5a6346e69937a48f0d7a58e5a
https://europepmc.org/articles/PMC3920738/
https://europepmc.org/articles/PMC3920738/
Publikováno v:
Biophysical Journal. 104(2)
Tamoxifen-inducible Cre-mediated gene excision is an important tool for spatiotemporal study of cardiac gene function, but tamoxifen administration can cause transient dilated cardiomyopathy and severely diminished contractile performance in MerCreMe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ad5a95313afee0bb6fb5d0dbdbfd7b
Publikováno v:
Biochimica et biophysica acta. 1833(4)
Diastolic dysfunction is characterized by slow or incomplete relaxation of the ventricles during diastole, and is an important contributor to heart failure pathophysiology. Clinical symptoms include fatigue, shortness of breath, and pulmonary and per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0314f4d9ed18325b932c029072bd84f
https://pubmed.ncbi.nlm.nih.gov/23022395
https://pubmed.ncbi.nlm.nih.gov/23022395
Autor:
Mark A. Sussman, Ross Whittaker, Rayne Fernandez, Natalie Gude, Christopher C. Glembotski, Joshua J. Martindale, Donna J. Thuerauf
Publikováno v:
Circulation research. 98(9)
Ischemia/reperfusion (I/R) affects the integrity of the endoplasmic reticulum (ER), the site of synthesis and folding of numerous proteins. Therefore, I/R may activate the unfolded protein response (UPR), resulting in the induction of a collection of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f968b3f9be10f26a3a3eb57cc44f4615
https://pubmed.ncbi.nlm.nih.gov/16690892
https://pubmed.ncbi.nlm.nih.gov/16690892