Výsledky vyhledávání - "Joshua J. Larson"

Akademický článek

Integrating interactive computational modeling in biology curricula.

Autor: Tomáš Helikar, Christine E Cutucache, Lauren M Dahlquist, Tyler A Herek, Joshua J Larson, Jim A Rogers

Publikováno v: PLoS Computational Biology, Vol 11, Iss 3, p e1004131 (2015)

While the use of computer tools to simulate complex processes such as computer circuits is normal practice in fields like engineering, the majority of life sciences/biological sciences courses continue to rely on the traditional textbook and memoriza

Externí odkaz: https://doaj.org/article/9f5ffbcdfb94414c9fa3285b748015dd

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Akademický článek

Design, Assessment, and In Vivo Evaluation of a Computational Model Illustrating the Role of CAV1 in CD4+ T Lymphocytes

Autor: Brittany D Conroy, Tyler A Herek, Timothy D Shew, Matthew eLatner, Joshua J Larson, Laura eAllen, Paul H Davis, Tomas eHelikar, Christine E Cutucache

Publikováno v: Frontiers in Immunology, Vol 5 (2014)

Caveolin-1 (CAV1) is a vital scaffold protein heterogeneously expressed in both healthy and malignant tissue. We focus on the role of CAV1 when overexpressed in T- cell leukemia. Previously, we have shown that CAV1 is involved in cell-to-cell communi

Externí odkaz: https://doaj.org/article/52fd51a102de49f3a1f5788dfcd07ccc

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Clinically Available Medicines Demonstrating Anti-Toxoplasma Activity

Autor: Joshua J. Larson, Andrew J. Neville, Lisa A. Davis, Sydney J. Zach, Abigail K. Judge, Jonathan L. Vennerstrom, Paul H. Davis, Xiaofang Wang

Publikováno v: Antimicrobial Agents and Chemotherapy. 59:7161-7169

Toxoplasma gondii is an apicomplexan parasite of humans and other mammals, including livestock and companion animals. While chemotherapeutic regimens, including pyrimethamine and sulfadiazine regimens, ameliorate acute or recrudescent disease such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d4724dc246989bc39554fa89bbc100
https://doi.org/10.1128/aac.02009-15

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Novel Toxoplasma gondii inhibitor chemotypes

Autor: Austin G. Sanford, Paul H. Davis, Lakshmi-Prasad Potluri, Ryan M. Hemsley, Sydney J. Zach, Joshua J. Larson, Thomas T. Schulze, Abigail K. Judge, Jonathan L. Vennerstrom, Xiaofang Wang, Susan A. Charman

Publikováno v: Parasitology international. 67(2)

We profiled three novel T. gondii inhibitors identified from an antimalarial phenotypic high throughput screen (HTS) campaign: styryl 4-oxo-1,3-benzoxazin-4-one KG3, tetrahydrobenzo[b]pyran KG7, and benzoquinone hydrazone KG8. These compounds inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5cbb44de25ada949a325aa7262a1bc
https://pubmed.ncbi.nlm.nih.gov/29081387

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A novel method for simulating insulin mediated GLUT4 translocation

Autor: Paul H. Davis, Beata J. Wysocki, Joshua J. Larson, Tadeusz A. Wysocki, Andrew J. Jezewski

Publikováno v: Biotechnology and Bioengineering. 111:2454-2465

Glucose transport in humans is a vital process which is tightly regulated by the endocrine system. Specifically, the insulin hormone triggers a cascade of intracellular signals in target cells mediating the uptake of glucose. Insulin signaling trigge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5399624557009b472a722f11d5044563
https://doi.org/10.1002/bit.25310

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Design, Assessment, and in vivo Evaluation of a Computational Model Illustrating the Role of CAV1 in CD4+ T-lymphocytes

Autor: Matthew Latner, Laura Allen, Paul H. Davis, TomÃ¡Å¡ Helikar, Timothy D. Shew, Joshua J. Larson, Tyler A. Herek, Christine E. Cutucache, Brittany D. Conroy

Publikováno v: Frontiers in Immunology, Vol 5 (2014)
Frontiers in Immunology

Caveolin-1 (CAV1) is a vital scaffold protein heterogeneously expressed in both healthy and malignant tissue. We focus on the role of CAV1 when overexpressed in T-cell leukemia. Previously, we have shown that CAV1 is involved in cell-to-cell communic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d319098d4cf61ec5ee6109c8de2aed
https://doi.org/10.3389/fimmu.2014.00599

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Integrating Interactive Computational Modeling in Biology Curricula

Autor: Lauren M. Dahlquist, Christine E. Cutucache, Tomáš Helikar, Jim A. Rogers, Joshua J. Larson, Tyler A. Herek

Publikováno v: PLoS Computational Biology
PLoS Computational Biology, Vol 11, Iss 3, p e1004131 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69fe5061bd5a973cdc6c9ec6e8047ac
https://doi.org/10.1371/journal.pcbi.1004131

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Akademický článek

Energy drink exposures reported to Texas poison centers: Analysis of adverse incidents in relation to total sales, 2010-2014.

Autor: Borron SW; Texas Tech University Health Sciences Center El Paso, Department of Emergency Medicine, 4801 Alberta Ave., Suite B3200, El Paso, TX 79905, United States; West Texas Regional Poison Center at University Medical Center of El Paso, 4815 Alameda Ave., El Paso, TX 79905, United States; SafetyCall International, PLLC, 3600 American Blvd. W., Suite 725, Bloomington, MN 55431, United States. Electronic address: stephen.borron@ttuhsc.edu., Watts SH; Texas Tech University Health Sciences Center El Paso, Department of Emergency Medicine, 4801 Alberta Ave., Suite B3200, El Paso, TX 79905, United States., Herrera J; Texas Tech University Health Sciences Center El Paso, Department of Emergency Medicine, 4801 Alberta Ave., Suite B3200, El Paso, TX 79905, United States., Larson J; Texas Tech University Health Sciences Center El Paso, Department of Emergency Medicine, 4801 Alberta Ave., Suite B3200, El Paso, TX 79905, United States., Baeza S; West Texas Regional Poison Center at University Medical Center of El Paso, 4815 Alameda Ave., El Paso, TX 79905, United States., Kingston RL; University of Minnesota College of Pharmacy, 308 SE. Harvard St., Minneapolis, MN 55455, United States; SafetyCall International, PLLC, 3600 American Blvd. W., Suite 725, Bloomington, MN 55431, United States.

Publikováno v: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2018 Aug; Vol. 97, pp. 1-14. Date of Electronic Publication: 2018 May 21.

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Akademický článek

Design and construction of a multiwavelength, micromirror total internal reflectance fluorescence microscope.

Autor: Larson J; 1] Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA. [2] Biophysics Graduate Program, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kirk M; Mad City Labs Inc., Madison, Wisconsin, USA., Drier EA; Mad City Labs Inc., Madison, Wisconsin, USA., O'Brien W; Mad City Labs Inc., Madison, Wisconsin, USA., MacKay JF; Mad City Labs Inc., Madison, Wisconsin, USA., Friedman LJ; Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA., Hoskins AA; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Publikováno v: Nature protocols [Nat Protoc] 2014 Oct; Vol. 9 (10), pp. 2317-28. Date of Electronic Publication: 2014 Sep 04.

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Akademický článek

Proasthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle.

Autor: Grunstein MM; Division of Pulmonary Medicine, Joseph Stokes Jr Research Institute, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. grunstein@email.chop.edu, Veler H, Shan X, Larson J, Grunstein JS, Chuang S

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2005 Jul; Vol. 116 (1), pp. 94-101.

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