Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus.

Autor: George J Leslie, Jianbin Wang, Max W Richardson, Beth S Haggarty, Kevin L Hua, Jennifer Duong, Anthony J Secreto, Andrea P O Jordon, Josephine Romano, Kritika E Kumar, Joshua J DeClercq, Philip D Gregory, Carl H June, Michael J Root, James L Riley, Michael C Holmes, James A Hoxie

Publikováno v: PLoS Pathogens, Vol 12, Iss 11, p e1005983 (2016)

HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and

Externí odkaz: https://doaj.org/article/b2848b8f422e4d1cb691aa0474392450

Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors

Autor: Paula M. Cannon, Joshua J. DeClercq, Jianbin Wang, Philip D. Gregory, Colin M. Exline, Samuel B. Hayward, Richard T. Surosky, David A. Shivak, G. Nicholas Llewellyn, Michael C. Holmes, Patrick Li

Publikováno v: Nature biotechnology

Genome editing with targeted nucleases and DNA donor templates homologous to the break site has proven challenging in human hematopoietic stem and progenitor cells (HSPCs), and particularly in the most primitive, long-term repopulating cell populatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255407628e9aa3377c850dda51a7bdc0
https://pubmed.ncbi.nlm.nih.gov/26551060

Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery

Autor: Joshua J. DeClercq, Jianbin Wang, Philip D. Gregory, David A. Shivak, Gary Lee, Samuel B. Hayward, Michael C. Holmes, Patrick Li

Publikováno v: Nucleic Acids Research

The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise in recent clinical trials. Nuclease-driven genome editing provides a method in which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265b333561b82aac3dcdae94af32872a
http://europepmc.org/articles/PMC4756813

Comparative Time to Improvement in Nonoperative and Operative Treatment of Rotator Cuff Tears.

Autor: Song A; Departments of Physical Medicine and Rehabilitation (A.S. and N.B.J.), Orthopaedics and Rehabilitation (N.B.J. and J.E.K.), and Biostatistics (J.D. and G.D.A.), Vanderbilt University Medical Center, Nashville, Tennessee., DeClercq J; Departments of Physical Medicine and Rehabilitation (A.S. and N.B.J.), Orthopaedics and Rehabilitation (N.B.J. and J.E.K.), and Biostatistics (J.D. and G.D.A.), Vanderbilt University Medical Center, Nashville, Tennessee., Ayers GD; Departments of Physical Medicine and Rehabilitation (A.S. and N.B.J.), Orthopaedics and Rehabilitation (N.B.J. and J.E.K.), and Biostatistics (J.D. and G.D.A.), Vanderbilt University Medical Center, Nashville, Tennessee., Higgins LD; King Edward Memorial Hospital, Hamilton, Bermuda., Kuhn JE; Departments of Physical Medicine and Rehabilitation (A.S. and N.B.J.), Orthopaedics and Rehabilitation (N.B.J. and J.E.K.), and Biostatistics (J.D. and G.D.A.), Vanderbilt University Medical Center, Nashville, Tennessee., Baumgarten KM; Orthopedic Institute of Sioux Falls, Sioux Falls, South Dakota., Matzkin E; Department of Orthopaedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Jain NB; Departments of Physical Medicine and Rehabilitation (A.S. and N.B.J.), Orthopaedics and Rehabilitation (N.B.J. and J.E.K.), and Biostatistics (J.D. and G.D.A.), Vanderbilt University Medical Center, Nashville, Tennessee.

Publikováno v: The Journal of bone and joint surgery. American volume [J Bone Joint Surg Am] 2020 Jul 01; Vol. 102 (13), pp. 1142-1150.

Closing the Gap: Identifying Rates and Reasons for Nonadherence in a Specialty Population.

Autor: Paolella D; Belmont University College of Pharmacy, Nashville, Tennessee., Cherry E; Vanderbilt Specialty Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee., Jolly JA; Vanderbilt Specialty Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee., DeClercq J; Vanderbilt Specialty Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee., Choi L; Vanderbilt Specialty Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee., Zuckerman A; Vanderbilt Specialty Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee.

Publikováno v: Journal of managed care & specialty pharmacy [J Manag Care Spec Pharm] 2019 Nov; Vol. 25 (11), pp. 1282-1288.