Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Joshua J Tu"'
A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus.
Autor:
Jennifer A Jenks, Sharmi Amin, Madeline R Sponholtz, Amit Kumar, Daniel Wrapp, Sravani Venkatayogi, Joshua J Tu, Krithika Karthigeyan, Sarah M Valencia, Megan Connors, Melissa J Harnois, Bhavna Hora, Eric Rochat, Jason S McLellan, Kevin Wiehe, Sallie R Permar
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011107 (2023)
Cytomegalovirus (CMV) is a leading cause of infant hearing loss and neurodevelopmental delay, but there are no clinically licensed vaccines to prevent infection, in part due to challenges eliciting neutralizing antibodies. One of the most well-studie
Externí odkaz:
https://doaj.org/article/111b8730bca84593945e121697cbd932
Autor:
Amit Kumar, Elena E Giorgi, Joshua J Tu, David R Martinez, Joshua Eudailey, Michael Mengual, Manukumar Honnayakanahalli Marichannegowda, Russell Van Dyke, Feng Gao, Sallie R Permar
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009478 (2021)
Despite considerable reduction of mother-to-child transmission (MTCT) of HIV through use of maternal and infant antiretroviral therapy (ART), over 150,000 infants continue to become infected with HIV annually, falling far short of the World Health Or
Externí odkaz:
https://doaj.org/article/9175324066cc4e44ade847ce15b4fe63
Autor:
Stephanie N. Langel, Francine L. Kelly, David M. Brass, Andrew E. Nagler, Dylan Carmack, Joshua J. Tu, Tatianna Travieso, Ria Goswami, Sallie R. Permar, Maria Blasi, Scott M. Palmer
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Summary Diacetyl (DA) is an α-diketone that is used to flavor microwave popcorn, coffee, and e-cigarettes. Occupational exposure to high levels of DA causes impaired lung function and obstructive airway disease. Additionally, lower levels of DA expo
Externí odkaz:
https://doaj.org/article/646ba4f0dd024f46b2eed9d2d8ac948a
Autor:
Ria Goswami, Veronica S. Russell, Joshua J. Tu, Charlene Thomas, Philip Hughes, Francine Kelly, Stephanie N. Langel, Justin Steppe, Scott M. Palmer, Timothy Haystead, Maria Blasi, Sallie R. Permar
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103412- (2021)
Summary: Currently available SARS-CoV-2 therapeutics are targeted toward moderately to severely ill patients and require intravenous infusions, with limited options for exposed or infected patients with no or mild symptoms. Although vaccines have dem
Externí odkaz:
https://doaj.org/article/ee780399eaa745259751f63b2147a779
Autor:
David R. Martinez, Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, Juilin Chen, Michael Mengual, Ayooluwa O. Douglas, Holly Heimsath, Kevin O. Saunders, Nathan I. Nicely, Joshua Eudailey, Giovanna Hernandez, Papa Kwadwo Morgan-Asiedu, Kevin Wiehe, Barton F. Haynes, M. Anthony Moody, Celia LaBranche, David C. Montefiori, Feng Gao, Sallie R. Permar
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Each year, >180,000 infants become infected via mother-to-child transmission (MTCT) of HIV despite the availability of effective maternal antiretroviral treatments, underlining the need for a maternal HIV vaccine. We characterized 224 matern
Externí odkaz:
https://doaj.org/article/547a9acf953c4c8cac9d486936a9784c
Autor:
Ria Goswami, Ashley N. Nelson, Joshua J. Tu, Maria Dennis, Liqi Feng, Amit Kumar, Jesse Mangold, Riley J. Mangan, Cameron Mattingly, Alan D. Curtis, Veronica Obregon-Perko, Maud Mavigner, Justin Pollara, George M. Shaw, Katharine J. Bar, Ann Chahroudi, Kristina De Paris, Cliburn Chan, Koen K. A. Van Rompay, Sallie R. Permar
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT To achieve long-term viral remission in human immunodeficiency virus (HIV)-infected children, novel strategies beyond early antiretroviral therapy (ART) will be necessary. Identifying clinical predictors of the time to viral rebound upon ART
Externí odkaz:
https://doaj.org/article/2d07f7f1798d4cddb1ebdeee807044e8
Publikováno v:
Frontiers in Microbiology. 13
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus which causes a lifelong infection. An estimated 5–10 million persons are infected with HTLV-1 worldwide – a number which is likely higher due to lack of reliable epidemi
Autor:
Joshua J. Tu, Amit Kumar, Elena E. Giorgi, Joshua Eudailey, Celia C. LaBranche, David R. Martinez, Genevieve G. Fouda, Yvetane Moreau, Allison Thomas, David Montefiori, Feng Gao, Manish Sagar, Sallie R. Permar
Publikováno v:
J Virol
Despite the worldwide availability of antiretroviral therapy (ART), approximately 150,000 pediatric HIV infections continue to occur annually. ART can dramatically reduce HIV mother-to-child transmission (MTCT), but inconsistent drug access and adher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c940a96df081b0b3e6a956cc2e2d3b
https://doi.org/10.1101/2022.02.03.479075
https://doi.org/10.1101/2022.02.03.479075
Autor:
Jennifer A. Jenks, Joshua J. Tu, Ningyan Zhang, Jesse F. Mangold, Dai Wang, Helen S. Webster, Tong-Ming Fu, Sallie R. Permar, Matthew L. Goodwin, Whitney Edwards, Jason S. McLellan, Justin Pollara, Hsuan-Yuan Wang, Daniel Wrapp, Cody S. Nelson, Sarah M. Valencia, Daniel C. Freed, Zhiqiang An
Publikováno v:
Virology
Human cytomegalovirus (HCMV) is the most common congenital infection. A glycoprotein B (gB) subunit vaccine (gB/MF59) is the most efficacious clinically tested to date, having achieved 50% protection against primary infection of HCMV-seronegative wom
Autor:
Richard J. Kuhn, Reynaldo Dietze, S. Munir Alam, Joshua Eudailey, Theodore C. Pierson, Jesse F. Mangold, Sarah M. Valencia, Camila Giuberti, Mattia Bonsignori, Joshua J. Tu, Maria Dennis, Morgan A. Gladden, Itzayana Miller, Helen M. Lazear, Sallie R. Permar, Cesar A. Lopez, Kan Luo, Summer L. Zhang, Kwan-Ki Hwang, Rebecca L. Jones, Andrew S. Miller, Robert J. Edwards, Tulika Singh, Katherine E. Burgomaster, Eng Eong Ooi, Tarra Von Holle, Helen S. Webster, Lakshmanane Premkumar
SummaryCongenital Zika virus (ZIKV) infection results in neurodevelopmental deficits in up to 14% of infants born to ZIKV-infected mothers. Neutralizing antibodies are a critical component of protective immunity. Here, we demonstrate that plasma IgM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e863815191ffee32e5c12f0f4df555
https://doi.org/10.1101/2021.11.23.469700
https://doi.org/10.1101/2021.11.23.469700