Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Joshua J Obar"'
Autor:
Joshua J Obar, Kelly M Shepardson
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011334 (2023)
Externí odkaz:
https://doaj.org/article/62064dde430644db85fcee58b6dcd9e2
Autor:
Sarah R Beattie, Kenneth M K Mark, Arsa Thammahong, Laure Nicolas Annick Ries, Sourabh Dhingra, Alayna K Caffrey-Carr, Chao Cheng, Candice C Black, Paul Bowyer, Michael J Bromley, Joshua J Obar, Gustavo H Goldman, Robert A Cramer
Publikováno v:
PLoS Pathogens, Vol 13, Iss 4, p e1006340 (2017)
Aspergillus fumigatus is responsible for a disproportionate number of invasive mycosis cases relative to other common filamentous fungi. While many fungal factors critical for infection establishment are known, genes essential for disease persistence
Externí odkaz:
https://doaj.org/article/40beb8360aa749b996a4d96db9aef212
Autor:
Alayna K Caffrey, Margaret M Lehmann, Julianne M Zickovich, Vanessa Espinosa, Kelly M Shepardson, Christopher P Watschke, Kimberly M Hilmer, Arsa Thammahong, Bridget M Barker, Amariliz Rivera, Robert A Cramer, Joshua J Obar
Publikováno v:
PLoS Pathogens, Vol 11, Iss 1, p e1004625 (2015)
Aspergillus fumigatus is a mold that causes severe pulmonary infections. Our knowledge of how A. fumigatus growth is controlled in the respiratory tract is developing, but still limited. Alveolar macrophages, lung resident macrophages, and airway epi
Externí odkaz:
https://doaj.org/article/33254b6f50f3465ca19c17126b63c850
Autor:
Kelly M Shepardson, Anupam Jhingran, Alayna Caffrey, Joshua J Obar, Benjamin T Suratt, Brent L Berwin, Tobias M Hohl, Robert A Cramer
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004378 (2014)
Hypoxia inducible factor 1α (HIF1α) is the mammalian transcriptional factor that controls metabolism, survival, and innate immunity in response to inflammation and low oxygen. Previous work established that generation of hypoxic microenvironments o
Externí odkaz:
https://doaj.org/article/4ec4164d03554a5692a1a6b58ab063dd
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e106060 (2014)
Intracellular pathogens are capable of inducing vigorous CD8+ T cell responses. However, we do not entirely understand the factors driving the generation of large pools of highly protective memory CD8+ T cells. Here, we studied the generation of endo
Externí odkaz:
https://doaj.org/article/c32947947d38400ba60f528da56844c7
Autor:
Daqi Xu, Han-Hsuan Fu, Joshua J Obar, Jang-June Park, Koji Tamada, Hideo Yagita, Leo Lefrançois
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56539 (2013)
Programmed death ligand-1 (PD-L1) is an important negative regulator of T cell immune responses via interactions with PD-1 and CD80. However, PD-L1 can also act as a positive costimulator, but the relevant counterreceptor is not known. We analyzed th
Externí odkaz:
https://doaj.org/article/5b9e06c8ae304e328c501986f2192ad6
Autor:
Ko-Wei Liu, Madeleine S. Grau, Jane T. Jones, Xi Wang, Elisa M. Vesely, Matthew R. James, Cecilia Gutierrez-Perez, Robert A. Cramer, Joshua J. Obar
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Aspergillus fumigatus is a human fungal pathogen that is most often avirulent in immunecompetent individuals because the innate immune system is efficient at eliminating fungal conidia. However, recent clinical observations have shown that s
Externí odkaz:
https://doaj.org/article/0dbf20e9d99a4ffaba87096a512d23d2
Autor:
Marina E. Kirkland, McKenzie Stannard, Caitlin H. Kowalski, Dallas Mould, Alayna Caffrey-Carr, Rachel M. Temple, Brandon S. Ross, Lotus A. Lofgren, Jason E. Stajich, Robert A. Cramer, Joshua J. Obar
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT Aspergillus fumigatus isolates display significant heterogeneity in growth, virulence, pathology, and inflammatory potential in multiple murine models of invasive aspergillosis. Previous studies have linked the initial germination of a funga
Externí odkaz:
https://doaj.org/article/a9d97d6657df4007937c146b431aced9
Autor:
Benjamin AWR Ralph, Melanie Lehoux, Hanna Ostapska, Brendan D. Snarr, Alayna K. Caffrey-Carr, Richard Fraser, Maya Saleh, Joshua J. Obar, Salman T. Qureshi, Donald C. Sheppard
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Aspergillus fumigatus airway infections are associated with increased rates of hospitalizations and declining lung function in patients with chronic lung disease. While the pathogenesis of invasive A. fumigatus infections is well studied, little is k
Externí odkaz:
https://doaj.org/article/d88a9100c3c944109606726bf7d86365
Autor:
Jane T. Jones, Ko-Wei Liu, Xi Wang, Caitlin H. Kowalski, Brandon S. Ross, Kathleen A. M. Mills, Joshua D. Kerkaert, Tobias M. Hohl, Lotus A. Lofgren, Jason E. Stajich, Joshua J. Obar, Robert A. Cramer
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
Allergic broncho-pulmonary aspergillosis (ABPA) patients often present with long-term colonization of Aspergillus fumigatusin vivo
Externí odkaz:
https://doaj.org/article/2d51c477fd3c4b37918cee6177e1c4da