Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Joshua J Gamsby"'
Autor:
Kelly C Heim, Joshua J Gamsby, Mary P Hever, Sarah J Freemantle, Jennifer J Loros, Jay C Dunlap, Michael J Spinella
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7639 (2009)
Mechanisms that underlie oscillatory transcriptional activity of nuclear receptors (NRs) are incompletely understood. Evidence exists for rapid, cyclic recruitment of coregulatory complexes upon activation of nuclear receptors. RIP140 is a NR coregul
Externí odkaz:
https://doaj.org/article/2d1f7ad0450446ba93ba15964ad48fed
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Circadian rhythm dysfunction occurs in both common and rare neurodegenerative diseases. This dysfunction manifests as sleep cycle mistiming, alterations in body temperature rhythms, and an increase in symptomatology during the early evening hours kno
Externí odkaz:
https://doaj.org/article/5af7af534a2d47f090567281b765398c
Autor:
Alexandra Portugues, John Faulkner, Cameron McNeill, Emily Peterson, Korey D. Stevanovic, Amara Yunus, H. Mahoney, David Gonzalez, Camden Burns, Amy Henriksen, Danielle Gulick, Christopher L. Cardona, Hannah S Justin, Joshua J. Gamsby
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Time-of-day effects have been noted in a wide variety of cognitive behavioral tests, and perturbation of the circadian system, either at the level of the master clock in the SCN or downstream, impairs hippocampus-dependent learning and memory. A numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314f3fb80d8b50f1903811ba49bef905
https://doaj.org/article/f756b73ad8f84855a26f61f1129e93c4
https://doaj.org/article/f756b73ad8f84855a26f61f1129e93c4
Autor:
Matthew D’Alessandro, Robert J. Tomko, Jae Kyoung Kim, Hyunjeong Joo, Stephen Beesley, Dae Wook Kim, Yuanhu Jin, Kwangjun Lee, Choogon Lee, Yang Young, John Faulkner, Joshua J. Gamsby
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Circadian rhythms including wake-sleep cycles are driven by molecular time cues generated by a self-sustaining transcriptional negative feedback loop. Among all clock proteins, PERIOD (PER) is considered the pacemaker protein because its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4cab81054039911bcec03f603a8580
https://doi.org/10.1073/pnas.2003524117
https://doi.org/10.1073/pnas.2003524117
Autor:
Maj-Linda B. Selenica, Kevin Ratnasamy, Chad A. Dickey, Margaret Fahnestock, Laura J. Blair, Kevin Nash, Daniel C. Lee, Devon Placides, Andrii Kovalenko, April L. Darling, Erin L. Abner, Huimin Liang, Camilla Michalski, Sarah N. Fontaine, John Ivan T. Calahatian, Leslie A. Sandusky-Beltran, Joshua J. Gamsby, Jeremy D. Baker, Jerry B. Hunt, Chao Ma
Publikováno v:
J Clin Invest
Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral impairments; however, mechanisms promoting tau pathology and how tau elicits behavioral impairment remain unclear. We report a unique interaction between polyamine me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33b1bc68c081762982c122956567e7b
https://doi.org/10.1172/jci126299
https://doi.org/10.1172/jci126299
Autor:
Korey D. Stevanovic, David G. Morgan, Joshua J. Gamsby, Danielle Gulick, Aurelie Joly-Amado, Amara Yunus, Marcia N. Gordon
Publikováno v:
Experimental Neurology. 294:58-67
Disruption of normal circadian rhythm physiology is associated with neurodegenerative disease, which can lead to symptoms such as altered sleep cycles. In Alzheimer's disease (AD), circadian dysfunction has been attributed to β-amyloidosis. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96c2fc0cd35f39a7a49b0232680b620
https://doi.org/10.1016/j.expneurol.2017.04.015
https://doi.org/10.1016/j.expneurol.2017.04.015
Autor:
H. Mahoney, C. Bloom, Danielle Gulick, A. Portugues, W. Li, Amara Yunus, Amy Henriksen, S. Azam, K. Millsaps, L. Pinto, M. Said, John Faulkner, S. K. Sundaram, M. Flores, S. Nagaraj, Joshua J. Gamsby, C. Burns
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
Circadian rhythm disruption is one of the earliest biomarkers of Alzheimer's disease (AD), and there exists a bidirectional relationship by which dysfunctions in the circadian clock drive AD pathology and AD pathology drives circadian dysfunction. Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598af267ea1cfa79c54330d9e2c5f627
https://doi.org/10.1038/s41598-019-51830-5
https://doi.org/10.1038/s41598-019-51830-5
Autor:
C. Burns, L. Pinto, S. Azam, S. K. Sundaram, C. Bloom, K. Millsaps, Joshua J. Gamsby, M. Flores, S. Nagaraj, Amara Yunus, H. Mahoney, M. Said, Danielle Gulick, W. Li, A. Portugues, Amy Henriksen, John Faulkner
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Circadian rhythm disruption is one of the earliest biomarkers of Alzheimer’s disease (AD), and there exists a bidirectional relationship by which dysfunctions in the circadian clock drive AD pathology and AD pathology drives circadian dysfunction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eac34bebab81943813e109ef3bd365d
https://doi.org/10.1038/s41598-019-50197-x
https://doi.org/10.1038/s41598-019-50197-x
Autor:
Joshua J. Gamsby, Danielle Gulick
Publikováno v:
Pharmacologytherapeutics. 188
Although potent effects of psychoactive drugs on circadian rhythms were first described over 30 years ago, research into the reciprocal relationship between the reward system and the circadian system - and the impact of this relationship on addiction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9281010dc5353af5180054ef419ba995
https://pubmed.ncbi.nlm.nih.gov/29551440
https://pubmed.ncbi.nlm.nih.gov/29551440
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 11 (2017)
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience
Adolescents naturally go to bed and awaken late, but are forced to awaken early for school and work. This leads to “social jetlag”, a state of circadian desynchrony (CD), in which internal biological rhythms are out of sync with behavioral rhythm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818b8124e9457f149b297b1efd169ec0