Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joshua J Elacqua"'
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195664 (2018)
Recent in vitro and in vivo studies have highlighted the importance of the cell nucleus in governing migration through confined environments. Microfluidic devices that mimic the narrow interstitial spaces of tissues have emerged as important tools to
Externí odkaz:
https://doaj.org/article/87af06dd449d485485944d96aea0054c
Autor:
Emily S. Bell, Pragya Shah, Noam Zuela-Sopilniak, Dongsung Kim, Alice-Anais Varlet, Julien L.P. Morival, Alexandra L. McGregor, Philipp Isermann, Patricia M. Davidson, Joshua J. Elacqua, Jonathan N. Lakins, Linda Vahdat, Valerie M. Weaver, Marcus B. Smolka, Paul N. Span, Jan Lammerding
Publikováno v:
Oncogene, 41, 4211-4230
Oncogene, 41, 36, pp. 4211-4230
Oncogene
Oncogene, 41, 36, pp. 4211-4230
Oncogene
Contains fulltext : 283431.pdf (Publisher’s version ) (Closed access) Aberrations in nuclear size and shape are commonly used to identify cancerous tissue. However, it remains unclear whether the disturbed nuclear structure directly contributes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70d1cbcd6f62c9638cc7b792ccc5bd7
https://doi.org/10.1038/s41388-022-02420-9
https://doi.org/10.1038/s41388-022-02420-9
Publikováno v:
Genome Res
DNA single-strand breaks (SSBs), or “nicks,” are the most common form of DNA damage. Oxidative stress, endogenous enzyme activities, and other processes cause tens of thousands of nicks per cell per day. Accumulation of nicks, caused by high rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7245d2d27b5182ca6b0b05be0fb0661
https://pubmed.ncbi.nlm.nih.gov/33355294
https://pubmed.ncbi.nlm.nih.gov/33355294
Quantification of somatic mutation flow across individual cell division events by lineage sequencing
Autor:
Joshua J Elacqua, Robert J. Kimmerling, Gad Getz, David Benjamin, Yehuda Brody, Paul C. Blainey, Scott R. Manalis, Yosef E. Maruvka, Kristjana Frangaj, Jaegil Kim, Kent W. Mouw, Amnon Koren, Nicholas J. Haradhvala
Publikováno v:
Genome Research. 28:1901-1918
Mutation data reveal the dynamic equilibrium between DNA damage and repair processes in cells and are indispensable to the understanding of age-related diseases, tumor evolution, and the acquisition of drug resistance. However, available genome-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fa9789c3d42d3aac57b48b1ab3c6d3
https://doi.org/10.1101/gr.238543.118
https://doi.org/10.1101/gr.238543.118
DNA single-strand breaks (SSBs), or ‘nicks’, are the most common form of DNA damage. Nicks occur at rates of tens of thousands per cell per day, and result from many sources including oxidative stress and endogenous enzyme activities. Accumulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbac2e72736ebb5e3a76bf5c75909a5
https://doi.org/10.1101/867937
https://doi.org/10.1101/867937
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 4, p e0195664 (2018)
PLoS ONE, Vol 13, Iss 4, p e0195664 (2018)
Recent in vitro and in vivo studies have highlighted the importance of the cell nucleus in governing migration through confined environments. Microfluidic devices that mimic the narrow interstitial spaces of tissues have emerged as important tools to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6a81f05218902c113a3ee8f90d073a
https://pubmed.ncbi.nlm.nih.gov/29649271
https://pubmed.ncbi.nlm.nih.gov/29649271
Publikováno v:
Cancer Research. 77:1897-1897
Invasion of tumor cells into the surrounding tissue is a critical step in the metastatic cascade, which is responsible for the vast majority of cancer-related deaths. Recent findings have begun to demonstrate that the biophysical properties of the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3745630d624afee0896b534910c4a9
https://doi.org/10.1158/1538-7445.am2017-1897
https://doi.org/10.1158/1538-7445.am2017-1897