Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joshua J Cull"'
Autor:
Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk
Cardiac hypertrophy is necessary for the heart to accommodate an increase in workload. Physiological, compensated hypertrophy (e.g. with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hyperte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cac2dcbbe2f252857669529379968100
https://doi.org/10.1101/2022.09.07.506723
https://doi.org/10.1101/2022.09.07.506723
Autor:
Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk
Publikováno v:
Clinical science (London, England : 1979). 136(22)
Cardiac hypertrophy is necessary for the heart to accommodate an increase in workload. Physiological, compensated hypertrophy (e.g. with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hyperte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6802b769e6422cf669bd69ae1a172885
https://pubmed.ncbi.nlm.nih.gov/36331065
https://pubmed.ncbi.nlm.nih.gov/36331065
Autor:
Jacqueline J.T. Marshall, Joshua J. Cull, Hajed O. Alharbi, May Zaw Thin, Susanna T.E. Cooper, Christopher Barrington, Hannah Vanyai, Thomas Snoeks, Bernard Siow, Alejandro Suáarez-Bonnet, Eleanor Herbert, Daniel J. Stuckey, Angus J.M. Cameron, Fabrice Prin, Andrew C. Cook, Simon L. Priestnall, Sonia Chotani, Owen J. L. Rackham, Daniel N. Meijles, Tim Mohun, Angela Clerk, Peter J. Parker
BackgroundThe protein kinase PKN2 is required for embryonic development, and PKN2 knockout mice die as a result of failure in expansion of mesoderm tissues, cardiac development and neural tube closure. In the adult, cardiomyocyte PKN2 and PKN1 (in co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da3f19d1a8b0542a8afece9e9c2fa48
https://openaccess.sgul.ac.uk/id/eprint/114588/1/bcj-2022-0281.pdf
https://openaccess.sgul.ac.uk/id/eprint/114588/1/bcj-2022-0281.pdf
Autor:
Daniel N. Meijles, Susanna T. E. Cooper, Peter E. Glennon, John Sembrat, Spencer Shaw, Leanne E. Felkin, Angela Clerk, Mauricio Rojas, Peter H. Sugden, Thomais Markou, Sam J. Leonard, M. N. Sheppard, K. Vanezis, Michelle A. Hardyman, Owen J. L. Rackham, Joshua J Cull, Paul J.R. Barton, Charles F. McTiernan, S A Cook, Sonia Chothani, Stephen J. Fuller, Hajed O. Alharbi
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121752225409a1c8d37392fa7f2ed3a0
https://doi.org/10.1101/2021.08.14.455637
https://doi.org/10.1101/2021.08.14.455637
Autor:
Angela Clerk, Daniel N. Meijles, Michelle A. Hardyman, Stephen J. Fuller, Sonia P. Chothani, Joshua J. Cull, Susanna T.E. Cooper, Hajed O. Alharbi, Konstantinos Vanezis, Leanne E. Felkin, Thomais Markou, Samuel J. Leonard, Spencer W. Shaw, Owen J.L. Rackham, Stuart A. Cook, Peter E. Glennon, Mary N. Sheppard, John C. Sembrat, Mauricio Rojas, Charles F. McTiernan, Paul J. Barton, Peter H. Sugden
Publikováno v:
The Biochemical journal. 479(3)
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fdb6f668651d275a7296a96d5f16fc
https://pubmed.ncbi.nlm.nih.gov/35147166
https://pubmed.ncbi.nlm.nih.gov/35147166
Autor:
Daniel N. Meijles, Hajed O. Alharbi, Angela Clerk, Michelle A. Hardyman, Peter H. Sugden, Liam J. McGuffin, Joshua J Cull, Stephen J. Fuller, Nick S. Edmunds
Publikováno v:
Biochemical Journal
The Ser/Thr kinase MAP4K4, like other GCKIV kinases, has N-terminal kinase and C-terminal citron homology (CNH) domains. MAP4K4 can activate c-Jun N-terminal kinases (JNKs), and studies in the heart suggest it links oxidative stress to JNKs and heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0258562b3a1847fd2244ac3a4af309a6
https://openaccess.sgul.ac.uk/id/eprint/113385/1/bcj-2021-0003.pdf
https://openaccess.sgul.ac.uk/id/eprint/113385/1/bcj-2021-0003.pdf
Autor:
Susanna T. E. Cooper, Angela Clerk, Stephen J. Fuller, Joshua J Cull, Hajed O. Alharbi, Peter H. Sugden, Daniel N. Meijles
Publikováno v:
Biochemical Journal
Insulin and insulin-like growth factor stimulate protein synthesis and cardioprotection in the heart, acting through their receptors (INSRs, IGF1Rs) and signalling via protein kinase B (PKB, also known as Akt). Protein synthesis is increased in heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5aeefe6e4ed0e769ba7ee2049de61e
https://openaccess.sgul.ac.uk/id/eprint/113355/1/bcj-2021-0144.pdf
https://openaccess.sgul.ac.uk/id/eprint/113355/1/bcj-2021-0144.pdf
Autor:
Daniel N. Meijles, Angela Clerk, Feroz Ahmad, Susanna T. E. Cooper, Peter H. Sugden, Zoe Haines, Stephen J. Fuller, Hajed O. Alharbi, Joshua J Cull, Viridiana Alcantara Alonso
Publikováno v:
Circulation. 142
Introduction: Epidermal growth factor (EGF) receptors (EGFRs: ERBB1-4) are activated by a family of ligands (e.g. EGF, Hb-EGF, EREG, TGFa), signaling through ERK1/2 and Akt to promote cell division and cancer. Antibody-based inhibition of ERBB2 in br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::962b9b5066f5b6ae234f8d9d449bd601
https://doi.org/10.1161/circ.142.suppl_3.16383
https://doi.org/10.1161/circ.142.suppl_3.16383
Autor:
Daniel N. Meijles, Angela Clerk, Spencer Shaw, Peter H. Sugden, Joshua J Cull, Stephen J. Fuller, Kerry A Rostron
Publikováno v:
Circulation Research. 123
Introduction: Akt signalling was delineated in the context of insulin stimulation and is cardioprotective. Akt is activated by insulin or insulin-like growth factor 1 (IGF1), acting through their receptors (IRs, IGF1Rs). Other receptors including α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdf21492f139f5eb5cba97834c55582d
https://doi.org/10.1161/res.123.suppl_1.443
https://doi.org/10.1161/res.123.suppl_1.443
Autor:
Daniel N. Meijles, Peter H. Sugden, Angela Clerk, Stephen J. Fuller, Joshua J Cull, Spencer Shaw, Kerry A Rostron
Publikováno v:
Basic Science.
Background Stress-regulated mitogen-activated protein kinases (SR-MAPKs; i.e. p38-MAPKs and JNKs) are activated by various stresses in the heart, causing cardiac dysfunction and cardiomyocyte death. Consequently, pathway components are potential ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4afa7aa0439fc3ffbb61fcafe918a337
https://doi.org/10.1136/heartjnl-2018-bcs.110
https://doi.org/10.1136/heartjnl-2018-bcs.110