Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joshua Heyza"'
Autor:
Pamela S. VanderVere-Carozza, Navnath S. Gavande, Shadia I. Jalal, Karen E. Pollok, Elmira Ekinci, Joshua Heyza, Steve M. Patrick, Andi Masters, John J. Turchi, Katherine S. Pawelczak
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination, and the DNA damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as a negative prognostic biomarker for
Externí odkaz:
https://doaj.org/article/1d4434aabcf24c4eb69ee21c9ff5887f
Autor:
Daniel P. Feldmann, Joshua Heyza, Christoph M. Zimmermann, Steve M. Patrick, Olivia M. Merkel
Publikováno v:
Molecules, Vol 25, Iss 8, p 1994 (2020)
Platinum-based chemotherapy remains a mainstay treatment for the management of advanced non-small cell lung cancer. A key cellular factor that contributes to sensitivity to platinums is the 5′-3′ structure-specific endonuclease excision repair cr
Externí odkaz:
https://doaj.org/article/a08d71c9cfa94092b6f0b5151adda9cb
Autor:
Agnes Malysa, Wenlong Bai, Hyejeong Jang, Steve M. Patrick, Joseph A. Caruso, Chen Hu, Joshua Heyza, Cong li Hu, Paul M. Stemmer, Niko Moses, Xiaohong Mary Zhang, Gerold Bepler, Wei Chen, Zhenkun Lou, Lisa Polin, Shengyan Xiang, Mu Zhang, Chuangui Wang
Publikováno v:
Cell Death and Disease, Vol 11, Iss 5, Pp 1-18 (2020)
Cell Death & Disease
Cell Death & Disease
Ubiquitin-specific peptidase 10 (USP10) stabilizes both tumor suppressors and oncogenes in a context-dependent manner. However, the nature of USP10’s role in non-small cell lung cancer (NSCLC) remains unclear. By analyzing The Cancer Genome Atlas (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8387a37b13c5864bed4364357aa1505e
http://link.springer.com/article/10.1038/s41419-020-2519-8
http://link.springer.com/article/10.1038/s41419-020-2519-8
Autor:
Pamela VanderVere-Carozza, Navnath Gavande, Shadia Jalal, Karen Pollok, Elmira Ekinci, Joshua Heyza, Steve Patrick, Andi Masters, John Turchi, Katherine Pawelczak
Publikováno v:
Cancer Research. 82:808-808
Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination and the DNA-damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as a negative prognostic biomarker for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c489abdbb31fc091373f30e5daed0ddc
https://doi.org/10.1158/1538-7445.am2022-808
https://doi.org/10.1158/1538-7445.am2022-808
Autor:
Steve M. Patrick, Shadia I. Jalal, Navnath S. Gavande, Karen E. Pollok, Joshua Heyza, Katherine S. Pawelczak, Elmira Ekinci, Pamela S. VanderVere-Carozza, John J. Turchi
Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination and the DNA-damage response (DDR). We have developed second generation RPA inhibitors (RPAi’s) that block the RPA-DNA interaction. These DNA-binding inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c5910c9d7973424a6550f764ab73cc6
https://doi.org/10.1101/2020.11.30.404640
https://doi.org/10.1101/2020.11.30.404640
Publikováno v:
Molecules
Molecules, Vol 25, Iss 1994, p 1994 (2020)
Molecules, Vol 25, Iss 1994, p 1994 (2020)
Platinum-based chemotherapy remains a mainstay treatment for the management of advanced non-small cell lung cancer. A key cellular factor that contributes to sensitivity to platinums is the 5′-3′ structure-specific endonuclease excision repair cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796c865cafe6f29c70cde54c97a78b54
http://europepmc.org/articles/PMC7221615
http://europepmc.org/articles/PMC7221615
Autor:
Gerold Bepler, Hao Zhang, Joshua Heyza, Vivian Kalman-Maltese, Sanjeevani Arora, Ashley M. Floyd, Steve M. Patrick, Kristin Tillison, Elaine M. Chalfin
Publikováno v:
Oncotarget
// Sanjeevani Arora 1 , Joshua Heyza 2 , Hao Zhang 2 , Vivian Kalman-Maltese 1 , Kristin Tillison 1 , Ashley M. Floyd 2 , Elaine M. Chalfin 1 , Gerold Bepler 2 , Steve M. Patrick 2 1 Department of Biochemistry & Cancer Biology, University of Toledo H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381cf2082625cb8ab6d221ee16933719
http://europepmc.org/articles/PMC5342726
http://europepmc.org/articles/PMC5342726
Publikováno v:
Biological Sciences Publications
Proteases are essential for normal physiology as well as multiple diseases, e.g., playing a causative role in cancer progression, including in tumor angiogenesis, invasion, and metastasis. Identification of dynamic alterations in protease activity ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d63d86a2c69085b38c207a3d05a8c80
https://doi.org/10.1016/j.biochi.2015.09.015
https://doi.org/10.1016/j.biochi.2015.09.015
Publikováno v:
Cancers
Volume 10
Issue 10
Cancers, Vol 10, Iss 10, p 368 (2018)
Volume 10
Issue 10
Cancers, Vol 10, Iss 10, p 368 (2018)
The radiation-induced bystander effect (RIBE) can increase cellular toxicity in a gap junction dependent manner in unirradiated bystander cells. Recent reports have suggested that cisplatin toxicity can also be mediated by functional gap junction int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ef2bd93fb791ba73e9a29d1953de77
Autor:
Donovan Watza, Jessica B. Back, Gerold Bepler, Steve M. Patrick, Ann G. Schwartz, Wei Chen, Joshua Heyza, Hao Zhang, Wen Lei
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(8)
Purpose: ERCC1/XPF is a DNA endonuclease with variable expression in primary tumor specimens, and has been investigated as a predictive biomarker for efficacy of platinum-based chemotherapy. The failure of clinical trials utilizing ERCC1 expression t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdd05654659e887ea52b186531caf1a
https://pubmed.ncbi.nlm.nih.gov/30728154
https://pubmed.ncbi.nlm.nih.gov/30728154