Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Joshua Hefler"'
Autor:
Joshua Hefler, Rena Pawlick, Braulio A. Marfil-Garza, Aducio Thiesen, Nerea Cuesta-Gomez, Sanaz Hatami, Darren H. Freed, Constantine Karvellas, David L. Bigam, A.M. James Shapiro
Publikováno v:
Liver Research, Vol 8, Iss 1, Pp 46-53 (2024)
Background and aim: The liver is susceptible to ischemia-reperfusion injury (IRI) during hepatic surgery, when the vessels are compressed to control bleeding, or liver transplantation, when there is an obligate period of ischemia. The hallmark of IRI
Externí odkaz:
https://doaj.org/article/693f51dceabc49638b6ca0e12260321d
Autor:
Alessandro Parente, MD, PhD, Kevin Verhoeff, MD, PhD, Tatsuya Kin, MD, PhD, Joshua Hefler, MD, PhD, Braulio A. Marfil-Garza, MD, PhD, Norberto Sanchez-Fernandez, MD, Anna Lam, MD, MSc, James Lyon, MD, PhD, Doug O’Gorman, BSc, Khaled Z. Dajani, MD, Blaire L. Anderson, MD, David L. Bigam, MD, MSc, Patrick E. MacDonald, MD, PhD, A. M. James Shapiro, MD, PhD, FRCS (Eng), FRCSC, MSM
Publikováno v:
Transplantation Direct, Vol 10, Iss 7, p e1667 (2024)
Background. Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors. We aimed to assess the feasibility and outcomes of ICI and ITx in MAiD donors. Me
Externí odkaz:
https://doaj.org/article/71afa965af904b5c8fc2cf5045e23fbe
Autor:
Lauren P. Westhaver, Sarah Nersesian, Riley J. Arseneau, Joshua Hefler, Breanna K.V. Hargreaves, Alexander Edgar, Yara Azizieh, Nerea Cuesta-Gomez, Dayne L. Izquierdo, A.M. James Shapiro, Boris L. Gala-Lopez, Jeanette E. Boudreau
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e27122- (2024)
Ex vivo normothermic machine perfusion (NMP) preserves donor organs and permits real-time assessment of allograft health, but the most effective indicators of graft viability are uncertain. Mitochondrial DNA (mtDNA), released consequent to traumatic
Externí odkaz:
https://doaj.org/article/48e0c9824b6843ca8c66c51224be8bf1
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Extracorporeal circulation (ECC) systems, including cardiopulmonary bypass, and extracorporeal membrane oxygenation have been an irreplaceable part of the cardiothoracic surgeries, and treatment of critically ill patients with respiratory and/or card
Externí odkaz:
https://doaj.org/article/68fb37d3bfef4e46a96b4e299e1b631f
Autor:
Joshua Hefler, Braulio A. Marfil-Garza, Rena L. Pawlick, Darren H. Freed, Constantine J. Karvellas, David L. Bigam, A. M. James Shapiro
Publikováno v:
PeerJ, Vol 9, p e12579 (2021)
Acute liver failure is marked by the rapid deterioration of liver function in a previously well patient over period of days to weeks. Though relatively rare, it is associated with high morbidity and mortality. This makes it a challenging disease to s
Externí odkaz:
https://doaj.org/article/e85735c87bd54f628821d613e43ad20d
Autor:
Joshua Hefler, Sanaz Hatami, Aducio Thiesen, Carly Olafson, Kiarra Durand, Jason Acker, Constantine J. Karvellas, David L. Bigam, Darren H. Freed, Andrew Mark James Shapiro
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2496 (2022)
Acute liver failure (ALF) is a rare but devastating disease associated with substantial morbidity and a mortality rate of almost 45%. Medical treatments, apart from supportive care, are limited and liver transplantation may be the only rescue option.
Externí odkaz:
https://doaj.org/article/583886382ee84f91a5f3824ce9124764
Autor:
Mariusz Bral, Rena Pawlick, Braulio Marfil-Garza, Nidheesh Dadheech, Joshua Hefler, Aducio Thiesen, A M James Shapiro
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224567 (2019)
BACKGROUND:Liver ischemia reperfusion injury (IRI) remains a challenge in liver transplantation. A number of compounds have previously demonstrated efficacy in mitigating IRI. Herein, we applied three specific additive strategies to a mouse IRI scree
Externí odkaz:
https://doaj.org/article/30011a69f31944838f0cb63870e2fbaa
Autor:
Joshua Hefler
Publikováno v:
University of Ottawa Journal of Medicine, Vol 5, Iss 1 (2015)
This case report is about a 43 year old man, who presented with a large paraesophageal hiatal hernia. Hiatal hernias are common and often asymptomatic. However, this patient’s hernia was caused by a large defect in his diaphragm, into which his sto
Externí odkaz:
https://doaj.org/article/d49c55d193cd4a35a0c66d183812852e
Publikováno v:
Biochemistry Research International, Vol 2015 (2015)
The transcription factor p53 is located at the centre of multiple pathways relating the cellular response to stress. Commonly known as a tumor suppressor, it is responsible for initiating diverse actions to protect the integrity of the genome, rangin
Externí odkaz:
https://doaj.org/article/e503139e988244799ed6bb39a5d2ea5d
Publikováno v:
PeerJ, Vol 1, p e29 (2013)
In the context of normal cell turnover, apoptosis is a natural phenomenon involved in making essential life and death decisions. Apoptotic pathways balance signals which promote cell death (pro-apoptotic pathways) or counteract these signals (anti-ap
Externí odkaz:
https://doaj.org/article/2b2447358dfd4d6eb7fd943d1ae7ef97