Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Joshua H. Singer"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
A presynaptic neuron can increase its computational capacity by transmitting functionally distinct signals to each of its postsynaptic cell types. To determine whether such computational specialization occurs over fine spatial scales within a neurite
Externí odkaz:
https://doaj.org/article/ae68a466094444d1adc26ee2c3475501
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Direction selectivity represents an elementary sensory computation that can be related to underlying synaptic mechanisms. In mammalian retina, direction-selective ganglion cells (DSGCs) respond strongly to visual motion in a “preferred” direction
Externí odkaz:
https://doaj.org/article/c91f8581878d41c89e3a8c0e66c4b5a9
Autor:
Lena S. Mortensen, Silvia J.H. Park, Jiang-bin Ke, Benjamin H. Cooper, Lei Zhang, Cordelia Imig, Siegrid Löwel, Kerstin Reim, Nils Brose, Jonathan B. Demb, Jeong-Seop Rhee, Joshua H. Singer
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2239-2250 (2016)
Complexin (Cplx) proteins modulate the core SNARE complex to regulate exocytosis. To understand the contributions of Cplx to signaling in a well-characterized neural circuit, we investigated how Cplx3, a retina-specific paralog, shapes transmission a
Externí odkaz:
https://doaj.org/article/3c96857817d840289321a4eb85904210
Autor:
Mark S. Cembrowski, Stephen M. Logan, Miao Tian, Li Jia, Wei Li, William L. Kath, Hermann Riecke, Joshua H. Singer
Publikováno v:
Cell Reports, Vol 1, Iss 2, Pp 155-166 (2012)
Several types of retinal interneurons exhibit spikes but lack axons. One such neuron is the AII amacrine cell, in which spikes recorded at the soma exhibit small amplitudes (5 ms). Here, we used electrophysiological recordings and computational analy
Externí odkaz:
https://doaj.org/article/0ae2677b428c4e93b2d90966177517d2
Publikováno v:
J Neurosci
Retinal bipolar cells (BCs) compose the canonical vertical excitatory pathway that conveys photoreceptor output to inner retinal neurons. Although synaptic transmission from BC terminals is thought to rely almost exclusively on Ca(2+) influx through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a848f4a689041d16ba498066b9d9d469
https://doi.org/10.1523/jneurosci.0183-22.2022
https://doi.org/10.1523/jneurosci.0183-22.2022
Autor:
Joyce Keung, Wei Li, Stephen C. Massey, James Carroll, Munenori Ishibashi, Joshua H. Singer, Christophe P. Ribelayga, Li Jia, Sue A. Aicher, Catherine W. Morgans, Iris Fahrenfort
Publikováno v:
eLife. 11
Electrical coupling, mediated by gap junctions, contributes to signal averaging, synchronization, and noise reduction in neuronal circuits. In addition, gap junctions may also provide alternative neuronal pathways. However, because they are small and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b95bcb6007a4c6d1d018f553f93294
https://doi.org/10.7554/elife.73039
https://doi.org/10.7554/elife.73039
Autor:
Munenori Ishibashi, Joyce Keung, Catherine W Morgans, Sue A Aicher, James R Carroll, Joshua H Singer, Li Jia, Wei Li, Iris Fahrenfort, Christophe P Ribelayga, Stephen C Massey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56a90618b0f2868471a40ee30904e789
https://doi.org/10.7554/elife.73039.sa2
https://doi.org/10.7554/elife.73039.sa2
Autor:
Morgan Musgrove, Joshua H. Singer, Miloslav Sedlacek, Hua Tian, Mrinalini Hoon, Fred Rieke, William N. Grimes, Amurta Nath, Jeffrey S. Diamond
Publikováno v:
Curr Biol
The morphology of retinal neurons strongly influences their physiological function. Ganglion cell (GC) dendrites ramify in distinct strata of the inner plexiform layer (IPL) so that GCs responding to light increments (ON) or decrements (OFF) receive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc06d5bb0912e4682af024374378775
https://europepmc.org/articles/PMC8792273/
https://europepmc.org/articles/PMC8792273/
Autor:
Nath A, Hua Tian, William N. Grimes, Joshua H. Singer, Miloslav Sedlacek, Mrinalini Hoon, Morgan Musgrove, Fred Rieke, Jeffrey S. Diamond
SummaryIn retinal neurons, morphology strongly influences visual response features. Ganglion cell (GC) dendrites ramify in distinct strata of the inner plexiform layer (IPL) so that GCs responding to light increments (ON) or decrements (OFF) receive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98781a20e5179f94ba06fdf26076576d
https://doi.org/10.1101/2021.07.01.450751
https://doi.org/10.1101/2021.07.01.450751
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86253 (2014)
Following photoreceptor degeneration, ON and OFF retinal ganglion cells (RGCs) in the rd-1/rd-1 mouse receive rhythmic synaptic input that elicits bursts of action potentials at ∼ 10 Hz. To characterize the properties of this activity, RGCs were ta
Externí odkaz:
https://doaj.org/article/95653ecc6c964d59890a2014c9ab1eae