Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Joshua H. Singer"'
Autor:
Munenori Ishibashi, Joyce Keung, Catherine W Morgans, Sue A Aicher, James R Carroll, Joshua H Singer, Li Jia, Wei Li, Iris Fahrenfort, Christophe P Ribelayga, Stephen C Massey
Publikováno v:
eLife, Vol 11 (2022)
Electrical coupling, mediated by gap junctions, contributes to signal averaging, synchronization, and noise reduction in neuronal circuits. In addition, gap junctions may also provide alternative neuronal pathways. However, because they are small and
Externí odkaz:
https://doaj.org/article/98f2cfe84eca42d9b5a289a232aebe1c
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
A presynaptic neuron can increase its computational capacity by transmitting functionally distinct signals to each of its postsynaptic cell types. To determine whether such computational specialization occurs over fine spatial scales within a neurite
Externí odkaz:
https://doaj.org/article/ae68a466094444d1adc26ee2c3475501
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Direction selectivity represents an elementary sensory computation that can be related to underlying synaptic mechanisms. In mammalian retina, direction-selective ganglion cells (DSGCs) respond strongly to visual motion in a “preferred” direction
Externí odkaz:
https://doaj.org/article/c91f8581878d41c89e3a8c0e66c4b5a9
Autor:
Silvia JH Park, Evan E Lieberman, Jiang-Bin Ke, Nao Rho, Padideh Ghorbani, Pouyan Rahmani, Na Young Jun, Hae-Lim Lee, In-Jung Kim, Kevin L Briggman, Jonathan B Demb, Joshua H Singer
Publikováno v:
eLife, Vol 9 (2020)
Night vision in mammals depends fundamentally on rod photoreceptors and the well-studied rod bipolar (RB) cell pathway. The central neuron in this pathway, the AII amacrine cell (AC), exhibits a spatially tuned receptive field, composed of an excitat
Externí odkaz:
https://doaj.org/article/1a1dcc80608b452db3fc0bfe5ad86051
Publikováno v:
J Neurosci
Retinal bipolar cells (BCs) compose the canonical vertical excitatory pathway that conveys photoreceptor output to inner retinal neurons. Although synaptic transmission from BC terminals is thought to rely almost exclusively on Ca(2+) influx through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a848f4a689041d16ba498066b9d9d469
https://doi.org/10.1523/jneurosci.0183-22.2022
https://doi.org/10.1523/jneurosci.0183-22.2022
Autor:
Lena S. Mortensen, Silvia J.H. Park, Jiang-bin Ke, Benjamin H. Cooper, Lei Zhang, Cordelia Imig, Siegrid Löwel, Kerstin Reim, Nils Brose, Jonathan B. Demb, Jeong-Seop Rhee, Joshua H. Singer
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2239-2250 (2016)
Complexin (Cplx) proteins modulate the core SNARE complex to regulate exocytosis. To understand the contributions of Cplx to signaling in a well-characterized neural circuit, we investigated how Cplx3, a retina-specific paralog, shapes transmission a
Externí odkaz:
https://doaj.org/article/3c96857817d840289321a4eb85904210
Autor:
Joyce Keung, Wei Li, Stephen C. Massey, James Carroll, Munenori Ishibashi, Joshua H. Singer, Christophe P. Ribelayga, Li Jia, Sue A. Aicher, Catherine W. Morgans, Iris Fahrenfort
Publikováno v:
eLife. 11
Electrical coupling, mediated by gap junctions, contributes to signal averaging, synchronization, and noise reduction in neuronal circuits. In addition, gap junctions may also provide alternative neuronal pathways. However, because they are small and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b95bcb6007a4c6d1d018f553f93294
https://doi.org/10.7554/elife.73039
https://doi.org/10.7554/elife.73039
Autor:
Munenori Ishibashi, Joyce Keung, Catherine W Morgans, Sue A Aicher, James R Carroll, Joshua H Singer, Li Jia, Wei Li, Iris Fahrenfort, Christophe P Ribelayga, Stephen C Massey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56a90618b0f2868471a40ee30904e789
https://doi.org/10.7554/elife.73039.sa2
https://doi.org/10.7554/elife.73039.sa2
Autor:
Mark S. Cembrowski, Stephen M. Logan, Miao Tian, Li Jia, Wei Li, William L. Kath, Hermann Riecke, Joshua H. Singer
Publikováno v:
Cell Reports, Vol 1, Iss 2, Pp 155-166 (2012)
Several types of retinal interneurons exhibit spikes but lack axons. One such neuron is the AII amacrine cell, in which spikes recorded at the soma exhibit small amplitudes (5 ms). Here, we used electrophysiological recordings and computational analy
Externí odkaz:
https://doaj.org/article/0ae2677b428c4e93b2d90966177517d2
Publikováno v:
eLife, Vol 4 (2015)
Dense connectomic mapping of neuronal circuits is limited by the time and effort required to analyze 3D electron microscopy (EM) datasets. Algorithms designed to automate image segmentation suffer from substantial error rates and require significant
Externí odkaz:
https://doaj.org/article/0088c1359cb84b7394cbe6c221052f75