Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joshua H K Tam"'
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0161445 (2016)
The amyloid hypothesis posits that the production of β-amyloid (Aβ) aggregates leads to neurodegeneration and cognitive decline associated with AD. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretas
Externí odkaz:
https://doaj.org/article/9e36832fd9184f6c873e5c3e673f2c6c
Autor:
Fabiana A Caetano, Brennan S Dirk, Joshua H K Tam, P Craig Cavanagh, Maria Goiko, Stephen S G Ferguson, Stephen H Pasternak, Jimmy D Dikeakos, John R de Bruyn, Bryan Heit
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 12, p e1004634 (2015)
Our current understanding of the molecular mechanisms which regulate cellular processes such as vesicular trafficking has been enabled by conventional biochemical and microscopy techniques. However, these methods often obscure the heterogeneity of th
Externí odkaz:
https://doaj.org/article/4f80efcfac3d4cf9ba07173424149539
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0161445 (2016)
PLoS ONE
PLoS ONE
The amyloid hypothesis posits that the production of β-amyloid (Aβ) aggregates leads to neurodegeneration and cognitive decline associated with AD. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c437da31134540da83fd744020629c
http://europepmc.org/articles/PMC5077117?pdf=render
http://europepmc.org/articles/PMC5077117?pdf=render
Autor:
Francisco Martínez-Santiesteban, Robert Ta, Robert Bartha, Robert H. E. Hudson, Stephen H. Pasternak, Alex X. Li, Joshua H. K. Tam, Mojmir Suchy, Timothy J. Scholl
Publikováno v:
Contrast Media & Molecular Imaging. 8:127-139
Currently there are no approved biomarkers for the pre-symptomatic diagnosis of Alzheimer's disease (AD). Cathepsin-D (Cat-D) is a lysosomal protease that is present at elevated levels in amyloid plaques and neurons in patients with AD and is also el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5bd395c75909e4bd77a9fc9384b5216
https://doi.org/10.1002/cmmi.1502
https://doi.org/10.1002/cmmi.1502
Autor:
Stephen H. Pasternak, Joshua H. K. Tam
Publikováno v:
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 39:286-298
Alzheimer's disease (AD) is poised to become the most serious healthcare issue of our generation. The leading theory of AD pathophysiology is the Amyloid Cascade Hypothesis, and clinical trials are now proceeding based on this hypothesis. Here, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c737c42298af1bd97a446be71fe0cf
https://doi.org/10.1017/s0317167100013408
https://doi.org/10.1017/s0317167100013408
Autor:
Joshua H K Tam, Stephen H. Pasternak
Publikováno v:
Journal of Visualized Experiments.
Beta-amyloid (Aβ) is the major constituent of senile plaques found in the brains of Alzheimer's disease patients. Aβ is derived from the sequential cleavage of Amyloid Precursor Protein (APP) by β and γ-secretases. Despite the importance of Aβ t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c288b0c7db7b66bb58b1f8f43335e0
https://doi.org/10.3791/53153
https://doi.org/10.3791/53153
Autor:
Stephen H. Pasternak, Andrea Tyrer, Sean P. Cregan, Susan O. Meakin, Justin Chiu, Joshua H. K. Tam, Weihao Tang, Claudia Seah
Publikováno v:
Paediatrics Publications
Molecular Brain
Molecular Brain
Alzheimer’s disease (AD) is characterized by the deposition of Beta-Amyloid (Aβ) peptides in the brain. Aβ peptides are generated by cleavage of the Amyloid Precursor Protein (APP) by the β − and γ − secretase enzymes. Although this process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17848c203fb3f1b4b21a83ae4b89df5
https://ir.lib.uwo.ca/paedpub/1568
https://ir.lib.uwo.ca/paedpub/1568
Autor:
Robert, Ta, Mojmir, Suchy, Joshua H K, Tam, Alex X, Li, Francisco S, Martinez-Santiesteban, Timothy J, Scholl, Robert H E, Hudson, Robert, Bartha, Stephen H, Pasternak
Publikováno v:
Contrast mediamolecular imaging. 8(2)
Currently there are no approved biomarkers for the pre-symptomatic diagnosis of Alzheimer's disease (AD). Cathepsin-D (Cat-D) is a lysosomal protease that is present at elevated levels in amyloid plaques and neurons in patients with AD and is also el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c1f565ed7310c4b08cc3d29e2c19fb7
https://pubmed.ncbi.nlm.nih.gov/23281285
https://pubmed.ncbi.nlm.nih.gov/23281285
Publikováno v:
Molecular Brain
Background Alzheimer’s disease (AD) is characterized by cerebral deposition of β-amyloid peptide (Aβ). Aβ is produced by sequential cleavage of the Amyloid Precursor Protein (APP) by β- and γ-secretases. Many studies have demonstrated that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31eb3f2eddbc2b80d892c866e8cb6a44