Výsledky vyhledávání - "Joshua G. Hilliard"

Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation

Autor: Stuart J. Macdonald, David J. Davido, Steven Haenchen, Lynda A. Morrison, Thornton W. Thompson, Adam J. Konen, Joshua G. Hilliard, Heba H. Mostafa

In the process of generating herpes simplex virus 1 (HSV-1) mutations in the viral regulatory gene encoding infected cell protein 0 (ICP0), we isolated a viral mutant, termed KOS-NA, that was severely impaired for acute replication in the eyes and tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2685679c9583b99eb64371d51f151fa7
https://europepmc.org/articles/PMC5972887/

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Herpes Simplex Virus 1 ICP0 Phosphorylation Site Mutants Are Attenuated for Viral Replication and Impaired for Explant-Induced Reactivation

Autor: Steven Haenchen, Thornton W. Thompson, Heba H. Mostafa, Adam M. Bayless, David J. Davido, Anna S. Kushnir, Joshua G. Hilliard, Emma Loveday, Malen A. Link, Priscilla A. Schaffer, Lisa A. Pitcher

Publikováno v: Journal of Virology. 85:12631-12637

In cell culture experiments, phosphorylation appears to be a critical regulator of the herpes simplex virus 1 (HSV-1) immediate-early (IE) protein, ICP0, which is an E3 ubiquitin ligase that transactivates viral gene expression. Three major regions o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275142413f8d912a5abd02ccd4095de3
https://doi.org/10.1128/jvi.05661-11

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A flow cytometric assay for the study of E3 ubiquitin ligase activity

Autor: Anne Cooper, Joyce G. Slusser, David J. Davido, Joshua G. Hilliard

Publikováno v: Cytometry Part A. :634-641

Current methods for monitoring E3 ubiquitin ligase activity in cell culture or in vivo are limited. As a result, the degradation of cellular targets by many E3 ubiquitin ligases in live cells has not yet been examined. For this study, a target of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0c2c3a0933c00f5fcd99bb8235abc4
https://doi.org/10.1002/cyto.a.20738

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Herpes Simplex Virus Type 1 ICP0 Phosphorylation Mutants Impair the E3 Ubiquitin Ligase Activity of ICP0 in a Cell Type-Dependent Manner

Autor: Roger D. Everett, David J. Davido, Chris Boutell, Anne Orr, Priscilla A. Schaffer, Joshua G. Hilliard

Publikováno v: Journal of Virology. 82:10647-10656

Herpes simplex virus type 1 (HSV-1) infected cell protein 0 (ICP0) is a 110-kDa nuclear phosphoprotein that is required for both the efficient initiation of lytic infection and the reactivation of quiescent viral genomes from latency. The ability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee75f9d99022a2400c9ffbaca8f211e8
https://doi.org/10.1128/jvi.01063-08

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