Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Joshua G Travers"'
Autor:
Ying-Hsi Lin, Jennifer L. Major, Tim Liebner, Zaynab Hourani, Joshua G. Travers, Sara A. Wennersten, Korey R. Haefner, Maria A. Cavasin, Cortney E. Wilson, Mark Y. Jeong, Yu Han, Michael Gotthardt, Scott K. Ferguson, Amrut V. Ambardekar, Maggie P.Y. Lam, Chunaram Choudhary, Henk L. Granzier, Kathleen C. Woulfe, Timothy A. McKinsey
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin
Externí odkaz:
https://doaj.org/article/150af97ede814fce977a15aa3d27a1dc
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Cardiovascular diseases remain the leading cause of death worldwide, with pathological fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying theme across etiologies. Despite the profound contributions of myocardial
Externí odkaz:
https://doaj.org/article/772b14e1ec6e445db0e2a4f14c0c9d64
Autor:
Marcello Rubino, Joshua G. Travers, Alaina L. Headrick, Blake T. Enyart, Madeleine E. Lemieux, Maria A. Cavasin, Jessica A. Schwisow, Elizabeth J. Hardy, Keenan J. Kaltenbacher, Marina B. Felisbino, Eric Jonas, Amrut V. Ambardekar, Michael R. Bristow, Keith A. Koch, Timothy A. McKinsey
Publikováno v:
Circulation Research. 132:10-29
Background: Organ fibrosis due to excessive production of extracellular matrix by resident fibroblasts is estimated to contribute to >45% of deaths in the Western world, including those due to cardiovascular diseases such as heart failure. Here, we s
Autor:
Michael Alexanian, Arun Padmanabhan, Tomohiro Nishino, Joshua G. Travers, Lin Ye, Clara Youngna Lee, Nandhini Sadagopan, Yu Huang, Angelo Pelonero, Kirsten Auclair, Ada Zhu, Barbara Gonzalez Teran, Will Flanigan, Charis Kee-Seon Kim, Koya Lumbao-Conradson, Mauro Costa, Rajan Jain, Israel Charo, Saptarsi M. Haldar, Katherine S. Pollard, Ronald J. Vagnozzi, Timothy A. McKinsey, Pawel F. Przytycki, Deepak Srivastava
Chronic inflammation and tissue fibrosis are common stress responses that worsen organ function, yet the molecular mechanisms governing their crosstalk are poorly understood. In diseased organs, stress-induced changes in gene expression fuel maladapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce3f813f15b68d411cced6b1ab15fc02
https://doi.org/10.1101/2023.01.06.522937
https://doi.org/10.1101/2023.01.06.522937
Autor:
Deborah M. Eaton, Remus M. Berretta, Jacqueline E. Lynch, Joshua G. Travers, Ryan D. Pfeiffer, Michelle L. Hulke, Huaqing Zhao, Alexander R. H. Hobby, Giana Schena, Jaslyn P. Johnson, Markus Wallner, Edward Lau, Maggie P. Y. Lam, Kathleen C. Woulfe, Nathan R. Tucker, Timothy A. McKinsey, Marla R. Wolfson, Steven R. Houser
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(4)
Approximately 50% of all heart failure (HF) diagnoses can be classified as HF with preserved ejection fraction (HFpEF). HFpEF is more prevalent in females compared with males, but the underlying mechanisms are unknown. We previously showed that press
Autor:
Timothy A McKinsey, Roger Foo, Chukwuemeka George Anene-Nzelu, Joshua G Travers, Ronald J Vagnozzi, Natalie Weber, Thomas Thum
Publikováno v:
Cardiovasc Res
Cardiovascular diseases and specifically heart failure (HF) impact global health and impose a significant economic burden on society. Despite current advances in standard of care, the risks for death and readmission of HF patients remain unacceptably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dedd354b349f46d52818fb03020a4f
https://europepmc.org/articles/PMC10202443/
https://europepmc.org/articles/PMC10202443/
Publikováno v:
Circulation. 142:963-966
Autor:
Deborah M Eaton, Remus M Berretta, Jacqueline E Lynch, Joshua G Travers, Kathleen C Woulfe, Ryan D Pfeiffer, Michelle L Hulke, Alexander R Hobby, Giana Schena, Jaslyn P Johnson, Markus Wallner, Nathan R Tucker, Timothy A McKinsey, Marla R Wolfson, Steven R Houser
Publikováno v:
Circulation. 144
Introduction: Approximately 50% of all heart failure (HF) diagnoses can be classified as HF with preserved ejection fraction (HFpEF), which has no FDA approved therapies. HFpEF is more prevalent in females compared to males, but the underlying mechan
Autor:
Timothy A. McKinsey, Jaslyn Johnson, Kathleen C. Woulfe, Giana Schena, Steven R. Houser, Jacqueline E Lynch, Joshua G Travers, Alexander R Hobby, Deborah M Eaton, M. Wallner, Marla R. Wolfson, Remus M. Berretta
Publikováno v:
Circulation Research. 129
Rationale: Heart Failure with preserved Ejection Fraction (HFpEF) accounts for approximately 50% of all HF diagnoses with no FDA approved therapies. HFpEF is more prevalent in females versus males, but the mechanisms driving the development of HFpEF
Autor:
George Gardner, Evangelia G. Kranias, Guo-Chang Fan, Guan-Sheng Liu, Jiang Qian, Yutian Li, Nathan Robbins, Kobra Haghighi, Jack Rubinstein, Burns C. Blaxall, Min Jiang, Joshua G. Travers
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • PKA-phosphorylation of Hsp20 is elevated in human failing hearts. • Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function. • The phosphorylated
Highlights • PKA-phosphorylation of Hsp20 is elevated in human failing hearts. • Increases in phosphorylated Hsp20 in vivo are associated with fibrotic remodeling and reduced left ventricular function. • The phosphorylated