Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Joshua F. G. Antoline"'
Autor:
Agnieszka Sulima, Fuying Li, Jeffrey Brian Morgan, Phong Truong, Joshua F. G. Antoline, Therese Oertel, Rodell C. Barrientos, Oscar B. Torres, Zoltan Beck, Gregory H. Imler, Jeffrey R. Deschamps, Gary R. Matyas, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 27, Iss 5, p 1553 (2022)
In our continuing effort to develop effective anti-heroin vaccines as potential medications for the treatment of opioid use disorder, herein we present the design and synthesis of the haptens: 1-AmidoMorHap (1), 1-AmidoMorHap epimer (2), 1 Amido-Dihy
Externí odkaz:
https://doaj.org/article/7dcc4f534c6c4cc6b767b5b5ab286a1c
Autor:
Erwin G. Abucayon, Connor Whalen, Oscar B. Torres, Alexander J. Duval, Agnieszka Sulima, Joshua F. G. Antoline, Therese Oertel, Rodell C. Barrientos, Arthur E. Jacobson, Kenner C. Rice, Gary R. Matyas
Publikováno v:
ACS omega. 7(30)
The quantitation of the available antibody binding-site concentration of polyclonal antibodies in serum is critical in defining the efficacy of vaccines against substances of abuse. We have conceptualized an equilibrium dialysis (ED)-based approach c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19ca968199eec25ae32ac775882c3ea
https://pubmed.ncbi.nlm.nih.gov/35936462
https://pubmed.ncbi.nlm.nih.gov/35936462
Autor:
Agnieszka Sulima, Fuying Li, Jeffrey Brian Morgan, Phong Truong, Joshua F. G. Antoline, Therese Oertel, Rodell C. Barrientos, Oscar B. Torres, Zoltan Beck, Gregory H. Imler, Jeffrey R. Deschamps, Gary R. Matyas, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules; Volume 27; Issue 5; Pages: 1553
In our continuing effort to develop effective anti-heroin vaccines as potential medications for the treatment of opioid use disorder, herein we present the design and synthesis of the haptens: 1-AmidoMorHap (1), 1-AmidoMorHap epimer (2), 1 Amido-Dihy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e99a4357a855e86f269f3343ad70e
https://pubmed.ncbi.nlm.nih.gov/35268659
https://pubmed.ncbi.nlm.nih.gov/35268659
Autor:
Kenner C. Rice, Joshua F. G. Antoline, Gary R. Matyas, Alexander J. Duval, Agnieszka Sulima, Carl R. Alving, Arthur E. Jacobson, Oscar B. Torres
Publikováno v:
Analytical and Bioanalytical Chemistry
We describe for the first time a method that utilizes microscale thermophoresis (MST) technology to determine polyclonal antibody affinities to small molecules. Using a novel type of heterologous MST, we have accurately measured a solution-based bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818546b0c242089c75b4dfe62821c2a7
https://doi.org/10.1007/s00216-018-1060-4
https://doi.org/10.1007/s00216-018-1060-4
Autor:
Joshua F. G. Antoline, Jeffrey R. Deschamps, Gary R. Matyas, Arthur E. Jacobson, Agnieszka Sulima, Kenner C. Rice, Gregory H. Imler, Zoltan Beck, Rashmi Jalah, Oscar B. Torres, Carl R. Alving
Publikováno v:
Journal of Medicinal Chemistry
An improved synthesis of a haptenic heroin surrogate 1 (6-AmHap) is reported. The intermediate needed for the preparation of 1 was described in the route in the synthesis of 2 (DiAmHap). A scalable procedure was developed to install the C-3 amido gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6becf954c1ba8b66e4282e02364add
http://europepmc.org/articles/PMC5767880
http://europepmc.org/articles/PMC5767880
Autor:
Gary R. Matyas, Carl R. Alving, Rashmi Jalah, Fuying Li, Arthur E. Jacobson, Oscar B. Torres, Joshua F. G. Antoline, Kenner C. Rice
Publikováno v:
Analytical and Bioanalytical Chemistry
The accurate analytical measurement of binding affinities of polyclonal antibody in sera to heroin, 6-acetylmorphine (6-AM), and morphine has been a challenging task. A simple nonradioactive method that uses deuterium-labeled drug tracers and equilib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726961eb038d1cc431e3c68d1316d6cc
http://europepmc.org/articles/PMC4718952
http://europepmc.org/articles/PMC4718952
Autor:
Oscar B. Torres, Fuying Li, Carl R. Alving, Zoltan Beck, Joshua F. G. Antoline, Malliga R. Iyer, Alexander V. Mayorov, Gary R. Matyas, Kejun Cheng, Kenner C. Rice, Arthur E. Jacobson
Publikováno v:
Vaccine. 32:1473-1479
Novel synthetic compounds similar to heroin and its major active metabolites, 6-acetylmorphine and morphine, were examined as potential surrogate haptens for the ability to interface with the immune system for a heroin vaccine. Recent studies have su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826ab7b104926cfe1e76a7220d1cb3da
https://doi.org/10.1016/j.vaccine.2014.01.028
https://doi.org/10.1016/j.vaccine.2014.01.028
Autor:
Gary R. Matyas, Arthur E. Jacobson, Kejun Cheng, Jeffrey R. Deschamps, Joshua F. G. Antoline, Fuying Li, Oscar B. Torres, Carl R. Alving, Malliga R. Iyer, Kenner C. Rice, Zoltan Beck, Rashmi Jalah, Damon A. Parrish
Publikováno v:
Org. Biomol. Chem.. 12:7211-7232
Three haptens have been synthesized with linkers for attachment to carrier macromolecules at either the piperidino-nitrogen or via an introduced 3-amino group. Two of the haptens, with a 2-oxopropyl functionality at either C6, or at both the C3 and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c71f6c502d766f3578bff3b7feed8f82
https://doi.org/10.1039/c4ob01053a
https://doi.org/10.1039/c4ob01053a
Autor:
Arthur E. Jacobson, Jeffrey R. Deschamps, Carl R. Alving, Fuying Li, Gary R. Matyas, Alexander V. Mayorov, Oscar B. Torres, Kenner C. Rice, Joshua F. G. Antoline, Zoltan Beck, Rashmi Jalah
Publikováno v:
Bioconjugate chemistry. 26(6)
Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effects of the drug by sequestering the drug in the blood and preventing it from crossing the blood-brain barrier. Drugs of abuse are too small to induce a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8709237c9b4a56197b2dab3445b579fb
https://pubmed.ncbi.nlm.nih.gov/25970207
https://pubmed.ncbi.nlm.nih.gov/25970207
Autor:
Fuying Li, Joshua F. G. Antoline, Arthur E. Jacobson, Gary R. Matyas, Kenner C. Rice, Carl R. Alving, Zoltan Beck, Rashmi Jalah, Oscar B. Torres
Publikováno v:
Drug and Alcohol Dependence. 156:e143
s / Drug and Alcohol Dependence 156 (2015) e102–e182 e143 Hapten selection for heroin vaccines Gary R. Matyas2, Fuying Li1,3, Joshua Antoline1,3, Rashmi Jalah4, Oscar Torres4, Zoltan Beck4, Arthur Jacobson1,3, Carl Alving2, Kenner Rice1,3 1 Drug De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01bf69875229fbf0373be5ab25287311
https://doi.org/10.1016/j.drugalcdep.2015.07.390
https://doi.org/10.1016/j.drugalcdep.2015.07.390