Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joshua F Alfaro"'
Autor:
Jessica L Martin, Phillip A Yates, Radika Soysa, Joshua F Alfaro, Feng Yang, Kristin E Burnum-Johnson, Vladislav A Petyuk, Karl K Weitz, David G Camp, Richard D Smith, Phillip A Wilmarth, Larry L David, Gowthaman Ramasamy, Peter J Myler, Nicola S Carter
Publikováno v:
PLoS Pathogens, Vol 10, Iss 2, p e1003938 (2014)
The ability of Leishmania to survive in their insect or mammalian host is dependent upon an ability to sense and adapt to changes in the microenvironment. However, little is known about the molecular mechanisms underlying the parasite response to env
Externí odkaz:
https://doaj.org/article/36e8f0994aaf4437ba1879260ecffd0a
Autor:
Suresh Gupta, Joshua F. Alfaro, Elijah M. Bolotin, Anita M. Leporati, Alexei A. Bogdanov, Marina Gottikh, Gerardo M. Castillo
Publikováno v:
Pharmaceutical research. 36(5)
PURPOSE. Developing and testing of microbicides for pre-exposure prophylaxis and post-exposure protection from HIV are on the list of major HIV/AIDS research priorities. To improve solubility and bioavailability of highly potent anti-retroviral drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ed6953a4bfa4321ace944441c8df4d
https://pubmed.ncbi.nlm.nih.gov/30919089
https://pubmed.ncbi.nlm.nih.gov/30919089
Autor:
Joshua F. Alfaro, Wenyun Ouyang, Joseph Nichols, Jeffrey P. Jones, Gregory J. Crouch, Carolyn A. Joswig-Jones
Publikováno v:
Drug Metabolism and Disposition. 37:2393-2398
Human aldehyde oxidase 1 (AOX1) has been subcloned into a vector suitable for expression in Escherichia coli, and the protein has been expressed. The resulting protein is active, with sulfur being incorporated in the molybdopterin cofactor. Expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f314b3b4ee8375d60eeb042b2bfd7214
https://doi.org/10.1124/dmd.109.029520
https://doi.org/10.1124/dmd.109.029520
Autor:
Jeffrey P. Jones, Joshua F. Alfaro
Publikováno v:
The Journal of Organic Chemistry. 73:9469-9472
DFT calculations support a concerted mechanism for xanthine oxidase and aldehyde oxidase hydride displacement from the sp(2) carbon of 6-substituted 4-quinazolinones. The variations in transition state structure show that C-O bond formation is nearly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec836cbc490b620bc733e1ffadd727c9
https://doi.org/10.1021/jo801053u
https://doi.org/10.1021/jo801053u
Autor:
Tianzhu Zang, Joshua J. Klaene, Shujia Dai, Zhaohui Sunny Zhou, Joshua F. Alfaro, Steven Clarke, He G. Sun, Barry L. Karger, Jonathan D. Lowenson, Laura A. Gillies, Byung Ju Kim
Publikováno v:
Analytical Chemistry. 80:3882-3889
Isoaspartate formation is a ubiquitous post-translation modification arising from spontaneous asparagine deamidation or aspartate isomerization. The formation of isoaspartate inserts a methylene group into the protein backbone, generating a "kink", a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455c3149a67777fa0a4cfac5e0c746df
https://doi.org/10.1021/ac800251q
https://doi.org/10.1021/ac800251q
Autor:
Kathleen M. Dorgan, Erin L. Karschner, DonRaphael P. Wynn, Zhaohui Sunny Zhou, Yinqiu Cui, Joan M. Hevel, Joshua F. Alfaro, Whitney L. Wooderchak
Publikováno v:
Analytical Biochemistry. 350:249-255
Modification of small molecules and proteins by methyltransferases affects a wide range of biological processes. Here, we report an enzyme-coupled continuous spectrophotometric assay to quantitatively characterize S-adenosyl-L-methionine (AdoMet/SAM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb132ba295204063998d6631a3685d5
https://doi.org/10.1016/j.ab.2006.01.004
https://doi.org/10.1016/j.ab.2006.01.004
Publikováno v:
Pharmaceutical Research. 21:2095-2104
This study aims to evaluate a cytochrome P450-based tamoxifen-isoflavone interaction and to determine the mechanisms responsible for inhibitory effects of isoflavones (e.g., genistein) on the formation of alpha-hydroxytamoxifen.Metabolism studies wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77923afa93aafb43383599b282f9674e
https://doi.org/10.1023/b:pham.0000048202.92930.61
https://doi.org/10.1023/b:pham.0000048202.92930.61
Publikováno v:
Organic Letters. 6:3043-3046
[reaction: see text] Quorum sensing is a process by which bacteria sense cell density. This cell-cell communication process is mediated by autoinducers. A cross-species messenger, autoinducer-2 (AI-2) is produced from S-ribosyl-L-homocysteine by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1f80252063beb08f7fd9d85b4a3d10
https://doi.org/10.1021/ol049182i
https://doi.org/10.1021/ol049182i
Autor:
Shahrzad Mansouri, Zhaohui Sunny Zhou, Joshua F. Alfaro, Kenneth A. Cornell, Wei Wan, Bonnie L. Bassler, Gang Zhao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3897-3900
Bacterial quorum sensing is mediated by autoinducers, small signaling molecules generated by bacteria. It has been proposed that the LuxS enzyme converts S-ribosyl-L-homocysteine to 4,5-dihydroxy-2,3-pentanedione, the precursor of autoinducer 2 (AI-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc28d50d4df3e2899107d52f0c446707
https://doi.org/10.1016/j.bmcl.2003.09.015
https://doi.org/10.1016/j.bmcl.2003.09.015
Publikováno v:
Journal of pharmaceutical sciences. 103(10)
The formation of aspartyl succinimide is a common post-translational modification of protein pharmaceuticals under acidic conditions. We present a method to detect and quantitate succinimide in intact protein via hydrazine trapping and chemical deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ae7d7e18a8f6e00de93dbabc84f1e8
https://pubmed.ncbi.nlm.nih.gov/25043726
https://pubmed.ncbi.nlm.nih.gov/25043726