Výsledky vyhledávání - "Joshua E. Mayfield"

Akademický článek

Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription

Autor: Qian Zhang, Wantae Kim, Svetlana B. Panina, Joshua E. Mayfield, Bede Portz, Y. Jessie Zhang

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract The C-terminal domain of RPB1 (CTD) orchestrates transcription by recruiting regulators to RNA Pol II upon phosphorylation. With CTD driving condensate formation on gene loci, the molecular mechanism behind how CTD-mediated recruitment of tr

Externí odkaz: https://doaj.org/article/5617c07b006f4dc7b2e870a33e0063c5

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Akademický článek

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

Autor: Bede Portz, Feiyue Lu, Eric B. Gibbs, Joshua E. Mayfield, M. Rachel Mehaffey, Yan Jessie Zhang, Jennifer S. Brodbelt, Scott A. Showalter, David S. Gilmour

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

The C-terminal domain (CTD) of RNA polymerase II is composed of a series of heptad repeats that exhibit some degree of sequence variation and that are subject to extensive phosphorylation. Here the authors provide evidence that local structural varia

Externí odkaz: https://doaj.org/article/9be77a77ce514f7ba76ca8962cfa5211

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Akademický článek

Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb

Autor: Joshua E Mayfield, Seema Irani, Edwin E Escobar, Zhao Zhang, Nathaniel T Burkholder, Michelle R Robinson, M Rachel Mehaffey, Sarah N Sipe, Wanjie Yang, Nicholas A Prescott, Karan R Kathuria, Zhijie Liu, Jennifer S Brodbelt, Yan Zhang

Publikováno v: eLife, Vol 8 (2019)

The Positive Transcription Elongation Factor b (P-TEFb) phosphorylates Ser2 residues of the C-terminal domain (CTD) of the largest subunit (RPB1) of RNA polymerase II and is essential for the transition from transcription initiation to elongation in

Externí odkaz: https://doaj.org/article/53e0122eb0c34ddbb874f06e2b7e518b

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Akademický článek

A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure

Autor: Adam J Pollak, Canzhao Liu, Aparna Gudlur, Joshua E Mayfield, Nancy D Dalton, Yusu Gu, Ju Chen, Joan Heller Brown, Patrick G Hogan, Sandra E Wiley, Kirk L Peterson, Jack E Dixon

Publikováno v: eLife, Vol 7 (2018)

Ca2+ signaling is important for many cellular and physiological processes, including cardiac function. Although sarcoplasmic reticulum (SR) proteins involved in Ca2+ signaling have been shown to be phosphorylated, the biochemical and physiological ro

Externí odkaz: https://doaj.org/article/ecc097f1b4894d6997ab24d9a2cc0ed7

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Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice

Publikováno v: J Bone Miner Res

Proper embryonic and postnatal skeletal development require coordination of myriad complex molecular mechanisms. Disruption of these processes, through genetic mutation, contributes to variation in skeletal development. We developed a high-throughput

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ad0a0b1f88f6e3ac5156b58cc85e92
https://doi.org/10.1002/jbmr.4323

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Ca2+-dependent liquid-liquid phase separation underlies intracellular Ca2+ stores

Autor: Joshua E. Mayfield, Dixon Je, Alexandra C. Newton, Worby Ca, Junqian Xu, Tandon, Pollak Aj

Endoplasmic/sarcoplasmic reticulum Ca2+ stores are essential to myriad cellular processes, however, the structure of these stores is largely unknown and existing models neither explain observations made in vivo nor sufficiently account for physiologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f702ebe46e3622f83791e2d1a0b4214
https://doi.org/10.1101/2021.07.06.451223

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