Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Joshua E Elias"'
Autor:
Piyali Saha, Justin L Shumate, Jenna G Caldwell, Nadia Elghobashi-Meinhardt, Albert Lu, Lichao Zhang, Niclas E Olsson, Joshua E Elias, Suzanne R Pfeffer
Publikováno v:
eLife, Vol 9 (2020)
Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. We introduced single disulfide bonds into NPC1 and NPC1L1 to explore the importance of inter-domain dynamics
Externí odkaz:
https://doaj.org/article/7772017ac6324284a75af39957bcc0d9
Autor:
J Aaron Crapster, Paul G Rack, Zane J Hellmann, Austen D Le, Christopher M Adams, Ryan D Leib, Joshua E Elias, John Perrino, Barry Behr, Yanfeng Li, Jennifer Lin, Hong Zeng, James K Chen
Publikováno v:
eLife, Vol 9 (2020)
Mammalian spermiogenesis is a remarkable cellular transformation, during which round spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that coordinate this process are not well understood, and we demonstrate here that h
Externí odkaz:
https://doaj.org/article/69dfb573f1c24a229b2802b43e4df09a
Autor:
Rupa Narayan, Niclas Olsson, Lisa E Wagar, Bruno C Medeiros, Everett Meyer, Debra Czerwinski, Michael S Khodadoust, Lichao Zhang, Liora Schultz, Mark M Davis, Joshua E Elias, Ron Levy
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219547 (2019)
Somatic mutations in cancer are a potential source of cancer specific neoantigens. Acute myeloid leukemia (AML) has common recurrent mutations shared between patients in addition to private mutations specific to individuals. We hypothesized that neoa
Externí odkaz:
https://doaj.org/article/edb0390b578b4750b2577bb7b8e15027
Autor:
Kun Leng, Brendan Rooney, Frank McCarthy, Wenlong Xia, Indigo V. L. Rose, Sophie Bax, Marcus Chin, Saeed Fathi, Kari A. Herrington, Manuel Leonetti, Aimee Kao, Stephen P. J. Fancy, Joshua E. Elias, Martin Kampmann
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying inf
Externí odkaz:
https://doaj.org/article/3362c7cd0c774b99bc1e41cc97a52ae6
Autor:
Michael J Boucher, Sreejoyee Ghosh, Lichao Zhang, Avantika Lal, Se Won Jang, An Ju, Shuying Zhang, Xinzi Wang, Stuart A Ralph, James Zou, Joshua E Elias, Ellen Yeh
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2005895 (2018)
Malaria parasites (Plasmodium spp.) and related apicomplexan pathogens contain a nonphotosynthetic plastid called the apicoplast. Derived from an unusual secondary eukaryote-eukaryote endosymbiosis, the apicoplast is a fascinating organelle whose fun
Externí odkaz:
https://doaj.org/article/d925f6a77f2445a2baa9c3bf5bedc363
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005725 (2015)
Aging in Caenorhabditis elegans is characterized by widespread physiological and molecular changes, but the mechanisms that determine the rate at which these changes occur are not well understood. In this study, we identify a novel link between repro
Externí odkaz:
https://doaj.org/article/f2cceb05cbdb4088bf3ded3d062efe9a
Autor:
Moritz Treeck, John L Sanders, Rajshekhar Y Gaji, Kacie A LaFavers, Matthew A Child, Gustavo Arrizabalaga, Joshua E Elias, John C Boothroyd
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004197 (2014)
Calcium-dependent protein kinases (CDPKs) are conserved in plants and apicomplexan parasites. In Toxoplasma gondii, TgCDPK3 regulates parasite egress from the host cell in the presence of a calcium-ionophore. The targets and the pathways that the kin
Externí odkaz:
https://doaj.org/article/524d9946ca3f4389accbbde822d34a7b
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8477 (2009)
Beta-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. BACE1 has been studied principally for its role in Alzheimer's
Externí odkaz:
https://doaj.org/article/be7c916f581b4de1b49c33ded3443273
Publikováno v:
PLoS Biology, Vol 6, Iss 10, p e257 (2008)
The presenilin/gamma-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover. Its ability to liberate numerous intracellular signaling proteins from the membrane and a
Externí odkaz:
https://doaj.org/article/fe592edaec7c4b538c0387aae75dc825
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Background The high diversity and complexity of the microbial community make it a formidable challenge to identify and quantify the large number of proteins expressed in the community. Conventional metaproteomics approaches largely rely on a
Externí odkaz:
https://doaj.org/article/b0bf936deb094e1fbedda9ad290d2dd0