Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Joshua E Elias"'
Autor:
Kun Leng, Brendan Rooney, Frank McCarthy, Wenlong Xia, Indigo V. L. Rose, Sophie Bax, Marcus Chin, Saeed Fathi, Kari A. Herrington, Manuel Leonetti, Aimee Kao, Stephen P. J. Fancy, Joshua E. Elias, Martin Kampmann
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying inf
Externí odkaz:
https://doaj.org/article/3362c7cd0c774b99bc1e41cc97a52ae6
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Background The high diversity and complexity of the microbial community make it a formidable challenge to identify and quantify the large number of proteins expressed in the community. Conventional metaproteomics approaches largely rely on a
Externí odkaz:
https://doaj.org/article/b0bf936deb094e1fbedda9ad290d2dd0
Autor:
Brad A. Palanski, Nielson Weng, Lichao Zhang, Andrew J. Hilmer, Lalla A. Fall, Kavya Swaminathan, Bana Jabri, Carolina Sousa, Nielsen Q. Fernandez-Becker, Chaitan Khosla, Joshua E. Elias
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Gluten peptides from wheat enter the bloodstream and are excreted in urine but are yet to be chemically characterised. Here, the authors show by mass spectrometry that quantitative and qualitative differences in urinary peptides can be detected betwe
Externí odkaz:
https://doaj.org/article/fbd7e5f524b5449e9eb03abee53037e8
Autor:
Evgeny Zatulovskiy, Michael C. Lanz, Shuyuan Zhang, Frank McCarthy, Joshua E. Elias, Jan M. Skotheim
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Increasing cell size drives changes to the proteome, which affects cell physiology. As cell size increases, some proteins become more concentrated while others are diluted. As a result, the state of the cell changes continuously with increasing size.
Externí odkaz:
https://doaj.org/article/1e1f1d973fe44e06a78a98a00e83a3e0
Autor:
Handuo Shi, Yan Hu, Pascal D. Odermatt, Carlos G. Gonzalez, Lichao Zhang, Joshua E. Elias, Fred Chang, Kerwyn Casey Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Bacterial cells actively change their size and shape in response to external environments. Here, Shi et al. explore how cells regulate their morphology during rapid environmental changes, showing that the characteristic dynamics of surface area-to-vo
Externí odkaz:
https://doaj.org/article/8655797fa5824bc7be32169e64b6d780
Autor:
Niclas Olsson, Marlene L. Heberling, Lichao Zhang, Suchit Jhunjhunwala, Qui T. Phung, Sarah Lin, Veronica G. Anania, Jennie R. Lill, Joshua E. Elias
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
All nucleated mammalian cells express major histocompatibility complex (MHC) proteins that present peptides on cell surfaces for immune surveillance. These MHC-presented peptides (pMHC) are necessary for directing T-cell responses against cells harbo
Externí odkaz:
https://doaj.org/article/6a589a1de5c44520a26a66ea507fd5a2
Autor:
Carlos G. Gonzalez, Hannah C. Wastyk, Madeline Topf, Christopher D. Gardner, Justin L. Sonnenburg, Joshua E. Elias
Publikováno v:
mSystems, Vol 5, Iss 3 (2020)
ABSTRACT Stool-based proteomics is capable of significantly augmenting our understanding of host-gut microbe interactions. However, compared to competing technologies, such as metagenomics and 16S rRNA sequencing, it is underutilized due to its low t
Externí odkaz:
https://doaj.org/article/7ca76f12b78f491aab440c6f1d3f68ee
Autor:
Piyali Saha, Justin L Shumate, Jenna G Caldwell, Nadia Elghobashi-Meinhardt, Albert Lu, Lichao Zhang, Niclas E Olsson, Joshua E Elias, Suzanne R Pfeffer
Publikováno v:
eLife, Vol 9 (2020)
Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. We introduced single disulfide bonds into NPC1 and NPC1L1 to explore the importance of inter-domain dynamics
Externí odkaz:
https://doaj.org/article/7772017ac6324284a75af39957bcc0d9
Autor:
J Aaron Crapster, Paul G Rack, Zane J Hellmann, Austen D Le, Christopher M Adams, Ryan D Leib, Joshua E Elias, John Perrino, Barry Behr, Yanfeng Li, Jennifer Lin, Hong Zeng, James K Chen
Publikováno v:
eLife, Vol 9 (2020)
Mammalian spermiogenesis is a remarkable cellular transformation, during which round spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that coordinate this process are not well understood, and we demonstrate here that h
Externí odkaz:
https://doaj.org/article/69dfb573f1c24a229b2802b43e4df09a
Autor:
Joshua E. Elias
Publikováno v:
HemaSphere, Vol 2, Pp 87-89 (2018)
Externí odkaz:
https://doaj.org/article/53314f0fc8bf44959ecc3f3be65b234e