Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joshua Disatham"'
Autor:
Joshua Disatham, Lisa Brennan, Xiaodong Jiao, Zhiwei Ma, J. Fielding Hejtmancik, Marc Kantorow
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-27 (2022)
Abstract Background Methylation at cytosines (mCG) is a well-known regulator of gene expression, but its requirements for cellular differentiation have yet to be fully elucidated. A well-studied cellular differentiation model system is the eye lens,
Externí odkaz:
https://doaj.org/article/e0ad742acd50493ba3fd5d99d50b3f5f
A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-20 (2021)
Abstract Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the
Externí odkaz:
https://doaj.org/article/fe214c6b805d407f9d0777f0111f7129
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 693 (2023)
Recent advances in next-generation sequencing and data analysis have provided new gateways for identification of novel genome-wide genetic determinants governing tissue development and disease. These advances have revolutionized our understanding of
Externí odkaz:
https://doaj.org/article/7643bf89b26d416e9940bfed6d99352b
Autor:
Marc Kantorow, A. Sue Menko, Daniel Chauss, Joshua Disatham, Rifah Gheyas, Lisa A. Brennan, Lauren Daley, David Blanco
Publikováno v:
Developmental Biology. 453:86-104
Changes in chromatin accessibility regulate the expression of multiple genes by controlling transcription factor access to key gene regulatory sequences. Here, we sought to establish a potential function for altered chromatin accessibility in control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920392b32e2e40ab30a8fc795f750893
https://doi.org/10.1016/j.ydbio.2019.04.020
https://doi.org/10.1016/j.ydbio.2019.04.020
Publikováno v:
Experimental eye research. 209
A hallmark feature of lens development and differentiation is the complete elimination of organelles from the center of the eye lens. A long unanswered question in lens biology is what are the mechanisms that control the elimination of organelles dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6231674d41f09d4ab61cad7641967a4a
https://pubmed.ncbi.nlm.nih.gov/34214522
https://pubmed.ncbi.nlm.nih.gov/34214522
A Functional Map of Genomic HIF1α-DNA Complexes in The Eye Lens Revealed Through Multiomics Analysis
Autor:
Marc Kantorow, Daniel Chauss, Jason Kantorow, Joshua Disatham, Behdad Afzali, Lisa A. Brennan
Publikováno v:
BMC Genomics
BMC Genomics, Vol 22, Iss 1, Pp 1-20 (2021)
BMC Genomics, Vol 22, Iss 1, Pp 1-20 (2021)
Background During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the core that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5937a6873de8395a2efdd5f1e143bfa1
https://doi.org/10.21203/rs.3.rs-247248/v1
https://doi.org/10.21203/rs.3.rs-247248/v1
Autor:
Zhiwei Ma, Daniel Chauss, Joshua Disatham, Xiaodong Jiao, Lisa Ann Brennan, A. Sue Menko, Marc Kantorow, J. Fielding Hejtmancik
Publikováno v:
Investigative Opthalmology & Visual Science. 63:8
Transition from lens epithelial cells to lens fiber cell is accompanied by numerous changes in gene expression critical for lens transparency. We identify expression patterns of highly prevalent genes including ubiquitous and enzyme crystallins in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38b052b34f00c0ff4661b7623e214d6
https://doi.org/10.1167/iovs.63.4.8
https://doi.org/10.1167/iovs.63.4.8
Publikováno v:
Exp Eye Res
Formation of the eye lens depends on the continuous differentiation of lens epithelial cells into lens fiber cells. To attain their mature structure and transparent function, nascent lens fiber cells must complete a precise cellular remodeling progra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e299863130a84ca57d9d680a812f9f7
https://doi.org/10.1016/j.exer.2020.108129
https://doi.org/10.1016/j.exer.2020.108129