Výsledky vyhledávání - "Joshua D. Seitz"

Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11C-Labeling

Autor: Tadashi Honda, Jacob G. Vineberg, Tao Wang, Joshua D. Seitz, Iwao Ojima

Publikováno v: The Journal of Organic Chemistry. 83:2847-2857

Next-generation taxoids, such as SB-T-1214, are highly potent cytotoxic agents that exhibit remarkable efficacy against drug-resistant tumors in vivo, including those that overexpress the P-glycoprotein (Pgp) efflux pump. As SB-T-1214 is not a substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b930908d2e87fd896747cf6d6c8b802d
https://doi.org/10.1021/acs.joc.7b03284

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Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for

Autor: Joshua D, Seitz, Tao, Wang, Jacob G, Vineberg, Tadashi, Honda, Iwao, Ojima

Publikováno v: The Journal of organic chemistry. 83(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a00efac63269c786d0d1b89ed779502
https://pubmed.ncbi.nlm.nih.gov/29441783

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Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate–taxoid conjugate

Autor: Evan Herlihy, Eduard Melief, Bora Park, Jacob G. Vineberg, Iwao Ojima, Joshua D. Seitz

Publikováno v: Bioorganic & Medicinal Chemistry. 23:2187-2194

The folate receptor (FR) has been widely recognized as an excellent target for the tumor-selective delivery of cytotoxic agents, and four folate-drug conjugates have entered clinical evaluations for the treatment of solid tumors to date. However, mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460472f87f9f960edffec5d440d3aec1
https://doi.org/10.1016/j.bmc.2015.02.057

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Differing Mechanisms of Death Induction by Fluorinated Taxane SB-T-12854 in Breast Cancer Cells

Autor: Michael Jelinek, Jan Šrámek, Joshua D. Seitz, Jan Kovar, Iwao Ojima, Adela Kabelova

Publikováno v: Anticancer research. 37(4)

BACKGROUND/AIM Classical taxanes are routinely used in cancer therapy. In this study, mechanisms involved in death induction by the novel fluorine-containing taxane SB-T-12854 were investigated. MATERIALS AND METHODS We employed breast cancer SK-BR-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb5d3d12041e500b4edead844f52966
https://pubmed.ncbi.nlm.nih.gov/28373418

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Design, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid–Camptothecin Combination Chemotherapy

Autor: Ying-Jen Chen, Joshua D. Seitz, Edison S. Zuniga, Anushree Kamath, Jacob G. Vineberg, Iwao Ojima

Publikováno v: Journal of Medicinal Chemistry

Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two warheads, self-immolative disulfide linkers for drug release, biotin as the tumor-targeting moiety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d741a776fbb7136242247dd9941d8e
https://doi.org/10.1021/jm500631u

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Poly(2-oxazoline) based Micelles with High Capacity for 3rd Generation Taxoids: preparation, in vitro and in vivo evaluation

Autor: Xiaomeng Wan, Zhijian He, Iwao Ojima, Herdis Bludau, Daria Y. Alakhova, Charles M. Perou, Alexander V. Kabanov, David B. Darr, Robert Luxenhofer, Rainer Jordan, Anita Schulz, Joshua D. Seitz

The clinically and commercially successful taxanes, paclitaxel and docetaxel suffer from two major drawbacks, namely their very low aqueous solubility and the risk of developing resistance. Here, we present a method that overcomes both drawbacks in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7152708cb2537fd2b520c8ac8702c8
https://europepmc.org/articles/PMC4479148/

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Design, Synthesis and Application of Fluorine-Labeled Taxoids as 19F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems

Autor: Brendan Lichtenthal, Jonathan F. Khan, Jacob G. Vineberg, Joshua D. Seitz, Longfei Wei, Chi-Feng Lin, Iwao Ojima

Novel tumor-targeting drug conjugates, BLT-F2 (1) and BLT-S-F6 (2), bearing a fluorotaxoid as the warhead, a mechanism-based self-immolative disulfide linker, and biotin as the tumor-targeting module, were designed and synthesized as 19F NMR probes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba63700ff355068d317789bc8057cc53
https://europepmc.org/articles/PMC4337250/

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Displacement reactions of 2-chloro- and 2,9-dichloro-1,10-phenanthroline: synthesis of a sulfur-bridged bis-1,10-phenanthroline macrocycle and a 2,2′-amino-substituted-bis-1,10-phenanthroline

Autor: Amber Leenstra, Silvia Sparapani, A. Paul Krapcho, Joshua D. Seitz

Publikováno v: Tetrahedron Letters. 50:3195-3197

The synthesis and structural assignments of 9-chloro-1,1-phenanthroline-2(1H)-thione and 1,10-dihydro-1,10-phenanthroline-2,9-dithione have been accomplished. The sulfur-bridged bis-1,10-phenanthroline macrocycle was readily prepared by heating the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::325680209f4aaab392a1bb82a54f6a68
https://doi.org/10.1016/j.tetlet.2009.01.138

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